Medi-Peel Peptide 9 Volume Tox Cream for oily acne-prone skin

How to apply

Questions and answers

What the research says

• Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

  International Journal of Cosmetic Science, 2018

• Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

  International Journal of Molecular Sciences, 2026

• Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.

  Journal of Cosmetic Dermatology, 2019

• Parthenolide and magnolol, as NF-kappaB inhibitors, effectively blocked UVB-induced gene expression, production of MMP-1 and bFGF, and proliferation of keratinocytes and melanocytes.

  Current Drug Metabolism, 2010

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.

  Archives of Facial Plastic Surgery, 2006

• A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.

  Cureus, 2024

• The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.

  Skin Research and Technology, 2026

• Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.

  Journal of Cosmetic Dermatology, 2022

• Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.

  International Journal of Molecular Sciences, 2022

• Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.

  Marine Drugs, 2023

• Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

  The Journal of Dermatology, 2008

• Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

  International Journal of Molecular Sciences, 2021

• Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures.

  The Journal of Investigative Dermatology, 2007

Why other moisturizers fit oily acne-prone skin better

• A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

  Journal of Cosmetic Dermatology, 2024

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Water, Methylpropanediol, Glycerin, Dimethicone, Cyclopentasiloxane, 1,2-Hexanediol, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Olivate, Cyclohexasiloxane, Sorbitan Olivate, Glyceryl Stearate, Pentaerythrityl Tetraisostearate, Peg-100 Stearate, Cetearyl Glucoside, Carbomer, Arginine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Trehalose, Helianthus Annuus Seed Oil Sunflower Seed Oil, Xanthan Gum, Adenosine, Polysorbate 80, Sodium Hyaluronate, Disodium Edta, Sorbitan Oleate, Glycine Soja Oil Soybean Oil, Desamido Collagen, Juniperus Communis Fruit Extract, Magnolia Officinalis Bark Extract, Eucalyptus Globulus Leaf Extract, Fructan, Hydrolyzed Collagen, Butylene Glycol, Hydrogenated Polyisobutene, Bixa Orellana Seed Oil, Propanediol, Sodium Hyaluronate Crosspolymer, Sorbitan Laurate, Propylene Glycol, Hydrolyzed Glycosaminoglycans, Nonoxynol-12, Phenoxyethanol, Chondrus Crispus Extract, Tocopherol, Hydroxyethylcellulose, Benzyl Glycol, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Ethyl Hexanediol, Hydrolyzed Elastin, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hexapeptide-9, Palmitoyl Tetrapeptide-7, Acetyl Octapeptide-3, Raspberry Ketone, Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.