Lancôme Rénergie H.P.N. 300-Peptide Cream for dry skin
Peptides
Sodium Hyaluronate
Niacinamide
Hydrolyzed Lupine Protein
Adenosine
Average
- HighDry Skin Fit
- AverageEffectiveness
- HighSafety
Works for dry skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your dry skin due to the presence of glycerin and hydrolyzed hyaluronic acid, which provide essential humectant action to hydrate and plump the skin. Niacinamide further supports skin barrier function and offers mild anti-inflammatory benefits, complementing the core moisturizing ingredients.
- The formula offers general skincare benefits that support dry or flaky skin, but it lacks specialized ingredients to directly address the core concerns of dryness and flakiness.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.
How to apply
- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
People Say
★4.7Overall rating based on 7.1k+ reviewsBased on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.
Highlights
Luxurious non-greasy texture Mostly Mentioned
- “rich cream that absorbs instantly”
- “feels like butter but not oily”
- “sinks in beautifully”
- “perfect under makeup”
Deep hydration Often Mentioned
- “skin feels hydrated all day”
- “no more dry patches”
- “leaves face feeling soft”
- “plumps up dehydration lines”
Visible anti-aging results Often Mentioned
- “jawline looks tighter”
- “fine lines are less visible”
- “skin feels plumper”
- “texture is much smoother”
High price point Often Mentioned
- “very expensive for the amount”
- “hard to justify the cost”
- “price is a bit steep”
- “wish it was more affordable”
Pleasant fragrance Sometimes Noted
- “smells absolutely divine”
- “light and fresh scent”
- “fragrance is lovely but not overpowering”
- “luxurious spa smell”
Refillable packaging Sometimes Noted
- “love that it is refillable”
- “beautiful heavy glass jar”
- “great sustainable option”
- “easy to replace the pod”
Heavy for oily skin Rarely Noted
- “too heavy for my oily zone”
- “made me look greasy”
- “clogged my pores”
- “better for night use only”
Lack of dramatic results Rarely Noted
- “didn't see a difference”
- “just a basic moisturizer”
- “not enough for very dry skin”
- “expected more for the price”
Skin irritation Rarely Noted
- “caused a red rash”
- “skin felt burning”
- “broke me out in hives”
- “irritated my sensitive skin”
Strong fragrance Rarely Noted
- “fragrance is too heavy”
- “smell lingers too long”
- “perfume irritated my eyes”
- “wish it was fragrance-free”
Sources: lovi.care, macys.com, ulta.com, lancome-usa.com, walmart.com, sephora.com, and more
Questions and answers
How well does Lancôme Rénergie H.P.N. 300-Peptide Cream work for dry skin?
Lancôme Rénergie H.P.N. 300-Peptide Cream works for your dry skin, though other products fit it better. It is safe and provides helpful hydration, but a product of this type needs more rich oils and protective sealants to deeply lock in moisture and fully target dry, flaky skin.
Which ingredients make this cream a good fit for dry skin?
Glycerin and hydrolyzed hyaluronic acid make this cream a good fit for dry skin by providing essential moisture to hydrate and plump it. To work best for dry skin, this type of product needs rich ingredients that specifically target moisture retention, along with a broader range of emollients and occlusives.
What do Peptides do for dry skin?
Peptides help dry skin by supporting skin barrier health and improving moisture retention. Regular use may also enhance skin firmness and smooth out the texture of dry skin over time.
What does Hyaluronic Acid do for dry skin?
Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Dermatology and Therapy, 2021Journal of Drugs in Dermatology, 2011
Where does this cream go in a skincare routine for dry skin?
This moisturizing treatment goes after your cleanser and hydrating toner in the morning, and after your treatment step in the evening. It is unlikely to irritate dry skin, but dry skin also needs rich butters and oils or barrier-repairing lipids to fully address deep dryness and flakiness.
The Journal of Dermatological Treatment, 2022Clinical, Cosmetic and Investigational Dermatology, 2017
Can I use this cream with retinol, and in what order?
You can use this cream with retinol by applying your retinol first, allowing it to absorb, and then following with the cream to help keep your skin comfortable and hydrated. This type of routine for dry skin needs rich, barrier-supporting ingredients like ceramides and heavier oils to truly lock in moisture and soothe flakiness.
How often should I use this cream?
You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular application helps maintain skin hydration and supports your skin barrier, with very low risk of irritation.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for dry skin?
This moisturizing treatment is unlikely to cause breakouts or clog pores on dry skin, and it has an excellent safety profile with very low risks of irritation. However, because it is an average fit for dry skin, it needs richer butters and oils to truly lock in moisture and comfort very dry or flaky areas.
Can I use this cream around the eyes or on my body?
You can use this moisturizing treatment around your eyes and on your body, as its safe formula is unlikely to cause irritation on delicate skin. However, dry skin on the body often needs richer butters and heavy oils to properly lock in moisture and comfort flaky areas.
Is this cream fragrance-free and alcohol-free?
It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Why other moisturizers fit dry skin better
Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss.
Acta Biochimica Polonica, 2012Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019
Ingredients
Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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