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Lancôme Advanced Génifique Night Cream for oily acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Lancôme Advanced Génifique Night Cream

Average

  • AverageOily Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for oily acne-prone skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate suitability for your oily skin, as Bifida Lysate Ferment and Glycerin provide some barrier repair and hydration, but it lacks sufficient ingredients for optimal oil control to address your main goals of managing acne and breakouts.
  • The formula provides excellent moisturizing and treatment due to bifida ferment lysate and sodium hyaluronate, enhancing barrier resilience and hydration, which are generally beneficial but not targeted for your specific concerns.
  • The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing agents like Bifida Lysate Ferment and Alpha-Glucan Oligosaccharide.

How to apply

  • Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
  • Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
  • Gently press a small amount into your skin and avoid rubbing to keep pores clear.
  • Apply on clean, slightly damp skin to help the product absorb better and control oil.
  • Avoid the sensitive eye area and do a simple patch test before your first use.

People Say

★4.7Overall rating based on 2.7k+ reviews

Based on a very large amount of data, this product is highly regarded for its ability to deeply hydrate dry and aging skin, effectively repair the moisture barrier, and leave the complexion feeling plump, smooth, and radiant by morning. It is frequently noted for reducing the appearance of fine lines and smoothing the skin texture. While most users find it absorbs quickly without a greasy feel, a small number of individuals with sensitive skin have reported experiencing breakouts or irritation, and some dislike the fragrance.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “The product provides deep hydration and visible rejuvenation.”
    • “Skin feels softer, smoother, and more hydrated.”
    • “Leaves skin moisturized and glowing.”
    • “Thick and moisturizing.”
  • Absorbs quickly Often Mentioned
    • “Doesn't have an oil feeling it's very light.”
    • “Absorbs quickly and leaves skin feeling refreshed without feeling greasy.”
    • “Thicker cream that does not make face feel greasy.”
    • “Does not leave the skin feeling sticky.”
  • Softens and smooths Often Mentioned
    • “Face is so soft, smooth and not puffy.”
    • “Goes on smoothly and makes skin feel like butter.”
    • “Skin feels softer, smoother, and more hydrated.”
    • “Leaves the skin feeling softer, smoother, and more radiant.”
  • Reduces fine lines Sometimes Noted
    • “Helps with wrinkles and makes skin soft.”
    • “Noticed a difference with the crows feet around my eyes.”
    • “Helps reduce the appearance of fine lines and wrinkles.”
    • “Reduces the appearance of fine lines and wrinkles, to leave skin looking youthful.”
  • Causes breakouts Rarely Noted
    • “Caused swelling and breakouts.”
    • “Had a few pimples that I didn't have before.”
    • “Did have one pimple below my eye.”
    • “Tiny pimples (bumps) on my jaw line and above my brows.”
  • Skin irritation Rarely Noted
    • “Started burning my face.”
    • “Smells very bad and itchy.”
    • “Caused swelling and breakouts.”
    • “Afraid to use it because it made me wonder what is in it.”
  • Unpleasant smell Rarely Noted
    • “Smells terrible, similar to hair bleach.”
    • “Smells like old sunscreen.”
    • “Smells very bad.”
    • “Disliked the fragrance.”

Sources: lovi.care, macys.com, lookfantastic.com, ulta.com, lancome-usa.com, nordstromrack.com, and more

Questions and answers

How well does Lancôme Advanced Génifique Night Cream work for oily acne-prone skin?

This cream is an average fit for oily acne-prone skin because while it provides good hydration and barrier repair, it lacks the ingredients needed for oil control to manage breakouts. To work better for this skin type, a product needs lightweight ingredients that provide hydration and target blemishes without clogging pores or adding excess oil.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for oily acne-prone skin?

Bifida Lysate Ferment, glycerin, and sodium hyaluronate make this cream a good fit by providing hydration and barrier repair without irritation. However, because this product only offers an average fit for oily acne-prone skin, a product of this type needs targeted oil-control ingredients, lightweight textures that do not clog pores, and blemish-managing agents to properly balance oil and breakouts.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Bifida Ferment Lysate do for oily acne-prone skin?

Bifida Ferment Lysate helps calm oily acne-prone skin by strengthening your skin barrier and lowering irritation. It is unlikely to clog pores and may help keep your skin feeling smooth and balanced.

Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010

What does Adenosine do for oily acne-prone skin?

Adenosine helps calm oily, acne-prone skin and supports a smooth, balanced look. It is generally well-tolerated and is unlikely to clog pores or cause irritation.

International Journal of Molecular Sciences, 2026The Journal of Clinical Investigation, 2014

Where does this cream go in a skincare routine for oily acne-prone skin?

This cream goes in the evening routine as a moisturizing treatment, applied after your cleansing toner and before your daytime or nighttime moisturizer. To truly fit oily acne-prone skin well, a product of this type needs dedicated oil-control and blemish-managing ingredients.

Can I use this cream with retinol, and in what order?

You can use this cream in your evening routine after applying retinol, as its soothing ingredients help keep your skin calm. Oily acne-prone skin needs a product of this type that also balances oil and targets breakouts.

Cutis, 2006

How often should I use this cream?

You can use this moisturizing treatment twice a day to keep your skin hydrated and support your skin barrier. Applying it regularly is unlikely to cause irritation on oily skin, though an oily acne-prone skin type needs a product with targeted oil-control ingredients to help manage breakouts.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream is unlikely to cause irritation or breakouts on your oily skin, as it has a very safe formula with soothing ingredients and a low rate of complaints. However, because it lacks sufficient oil-control ingredients to properly manage breakouts, oily acne-prone skin needs a product that includes targeted oil-balancing and blemish-clearing ingredients.

Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on your body, as its very safe formula with soothing agents is unlikely to cause irritation. However, oily acne-prone skin needs products with targeted oil control and blemish-clearing ingredients to properly manage breakouts in those areas.

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool, limonene, citronellol, and parfum). Behenyl alcohol and cetyl alcohol are fatty alcohols, which soften the skin.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.

    Journal of Cosmetic Dermatology, 2023

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

    Experimental Dermatology, 2003

  • Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

    Journal of Periodontology, 2009

  • Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

    Journal of Cosmetic Dermatology, 2022

Why other moisturizers fit oily acne-prone skin better

  • Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

    Molecules, 2023

  • A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels.

    Journal of Cosmetic Dermatology, 2017

  • A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

    Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Bifida Lysate Ferment, Glycerin, Dicaprylyl Ether, Pentylene Glycol, Polyglyceryl-6 Distearate, Propanediol, Cetyl Esters, Jojoba Esters, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Octyldodecanol, Acacia Decurrens Flower Cera, Acacia Decurrens Wax Flower, Helianthus Annuus Seed Cera, Sunflower Wax Seed, Helianthus Annuus Seed Oil, Sunflower Seed Oil, Polymnia Sonchifolia Root Juice, Ceramide Np, Alpha-Glucan Oligosaccharide, Sodium Hyaluronate, Sodium Hydroxide, Sodium Stearoyl Glutamate, Salicyloyl Phytosphingosine, 2-Oleamido-1, 3-Octadecanediol, Adenosine, Mannose, Coco-Caprylate Caprate, Ascorbyl Glucoside, Hydroxyacetophenone, Hydroxypalmitoyl Sphinganine, Hydroxypropyl Phosphate Starch, Capryloyl Salicylic Acid, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Lactobacillus, Acetic Acid, Maltodextrin, Yeast Extract, Extrait De Levure, Polyglycerin-3, Polyglyceryl-3 Beeswax, Cetyl Alcohol, Tocopherol, Sodium Benzoate, Linalool, Limonene, Citronellol, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play