La Roche-Posay Mela B3 Serum for oily acne-prone skin

How to apply

Questions and answers

What the research says

• Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris.

  Journal of Cosmetic Dermatology, 2021

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris.

  Journal of Drugs in Dermatology, 2013

• Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne.

  The Medical Journal of Malaysia, 2024

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes.

  Life, 2023

• A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro.

  International Journal of Cosmetic Science, 2025

• A formulation containing vitamin C, biopeptides, hyaluronic acid, and mineralizing water accelerated cell turnover to 17.1 days versus 19.2 days for untreated skin, and reduced crow's-feet, forehead, and nasolabial folds by 9%, 11%, and 5% respectively after 28 days in female subjects.

  International Journal of Cosmetic Science, 2021

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Ingredients

Water, Dimethicone, Niacinamide, Glycerin, Propylene Glycol, Polysilicone-11, Silica, Bis-Peg Ppg-16 16 Peg Ppg-16 16 Dimethicone, Cystoseira Tamariscifolia Extract, 2-Mercaptonicotinoyl Glycine, Peg-20 Methyl Glucose Sesquistearate, Sodium Hyaluronate, Sodium Hydroxide, Sodium Thiosulfate, Carnosine, Poloxamer 338, Ammonium Polyacryloyldimethyl Taurate, Dipotassium Glycyrrhizate, Caprylic Capric Triglyceride, Capryloyl Salicylic Acid, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Xanthan Gum, Pentylene Glycol, Octyldodecanol, Retinyl Palmitate, Tocopherol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Phenoxyethanol, Ci 17200 Red 33, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.