La Mer The Regenerating Serum for oily acne-prone skin

How to apply

Questions and answers

What the research says

• Petrolatum-based skin protectants demonstrated protection against irritants and maceration while providing skin hydration, whereas dimethicone and zinc oxide products showed varying or limited performance across parameters among 18 healthy volunteers compared to positive and negative controls.

  Ostomy/wound Management, 2005

• Topical application of 1% Fucus vesiculosus extract gel twice daily for five weeks significantly decreased skin thickness and improved elasticity in human cheek skin compared with controls.

  Journal of Cosmetic Science, 2002

• Topical astaxanthin-loaded algae extract hydrogel and lipogel formulations exhibited the highest antioxidant activity and successful in vitro release, suggesting their potential as anti-aging formulations.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Treatment with lipid algae extract reduced the level of oxidized proteins in human keratinocytes and stratum corneum skin cells.

  Annals of the New York Academy of Sciences, 2004

• Antarctic marine algae extracts increased cell viability, protected against inflammation, and enhanced the barrier integrity of human intestinal and keratinocyte cell lines damaged by lipopolysaccharide or ultraviolet radiation.

  Marine Drugs, 2022

• Treatment with bone marrow mesenchymal stem cells combined with Cystoseira algae extract significantly improved wound closure, tissue thickness, layer density, and skin elasticity while reducing oxidative indicators, pro-inflammatory cytokines, and immune markers in immunosuppressed rats compared to the control group.

  PloS One, 2024

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

Why other serums fit oily acne-prone skin better

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.

  BioMed Research International, 2022

Ingredients

Water, Algae Extract, Dimethicone, Hdi Trimethylol Hexyllactone Crosspolymer, Hydrogenated Polyisobutene, Caprylic Capric Myristic Stearic Triglyceride, Polysilicone-11, Peg-8 Dimethicone, Peg-10 Dimethicone, Yeast Faex Extrait De Levure Extract, Citrus Aurantifolia Peel Extract, Sigesbeckia Orientalis Extract, Polygonum Cuspidatum Root Extract, Saccharomyces Lysate Extract, Sesamum Indicum Seed Oil, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sesamum Indicum Seed Powder, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Vitis Vinifera Seed Extract Grape Seed Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Punica Granatum Fruit Juice, Bupleurum Falcatum Root Extract, Citrus Reticulata Peel Extract Tangerine Peel Extract, Narcissus Tazetta Bulb Extract, Mimosa Tenuiflora Bark Extract, Betula Alba Bark Extract, Chlorella Vulgaris Extract, Humulus Lupulus Extract, Laureth-4, Corallina Officinalis Extract, Glycine Soja Seed Extract Soybean Seed Extract, Micrococcus Lysate, Whey Lactis Proteine Du Petit-Lait Protein, Tartaric Acid, Glycerin, Hydrolyzed Wheat Protein, Laureth-23, Butylene Glycol, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Sucrose, Coenzyme A, Acetyl Glucosamine, Caffeine, Dipalmitoyl Hydroxyproline, Linoleic Acid, Tetraacetylphytosphingosine, Alcaligenes Polysaccharides, Bifida Lysate Ferment, Pentylene Glycol, Dipotassium Glycyrrhizate, Palmitoyl Oligopeptide, Peg-8, Sorbitol, Tocopheryl Acetate, Eryngium Maritimum Extract, Sodium Hydroxide, Hydrogenated Lecithin, Hydroxypropyl Cyclodextrin, Nordihydroguaiaretic Acid, Cyclodextrin, Maltodextrin, Acetyl Hexapeptide-8, Glyceryl Polymethacrylate, Glycosaminoglycans, Gold, Tourmaline, Linolenic Acid, Silica, Ethylbisiminomethylguaiacol Manganese Chloride, Disodium Edta, Potassium Sorbate, Phenoxyethanol, Parfum, Hydroxycitronellal, Linalool, Limonene, Citronellol, Geraniol, Green 5 Ci 61570

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.