La Mer The Lifting and Firming Mask for sensitive skin

How to apply

Questions and answers

What the research says

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

  European Journal of Neurology, 2013

• Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.

  International Journal of Biological Macromolecules, 2026

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Zinc gluconate induced alpha2, alpha3, alphaV, and alpha6 integrins, copper gluconate induced alpha2, alpha6, and beta1, and manganese gluconate induced most studied integrins in cultured keratinocytes.

  The British Journal of Dermatology, 1999

Why other nourishing masks fit sensitive skin better

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

Ingredients

Declustered Water, Water, Eau De-Structuree, Dimethicone, Hdi Trimethylol Hexyllactone Crosspolymer, Cyclopentasiloxane, Hydrogenated Polyisobutene, Hydrogenated Oil, Caprylic Capric Myristic Stearic Triglyceride, Polysilicone-11, Peg-100 Stearate, Peg-8 Dimethicone, Peg-10 Dimethicone, Algae Extract, Sesamum Indicum Seed Oil, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Vitis Vinifera Seed Extract Grape Seed Extract, Citrus Aurantifolia Peel Extract, Sigesbeckia Orientalis Extract, Crithmum Maritimum Extract, Eryngium Maritimum Extract, Polygonum Cuspidatum Root Extract, Silybum Marianum Extract, Bupleurum Falcatum Root Extract, Humulus Lupulus Extract, Citrus Reticulata Peel Extract Tangerine Peel Extract, Mimosa Tenuiflora Bark Extract, Narcissus Tazetta Bulb Extract, Chlorella Vulgaris Extract, Saccharomyces Lysate Extract, Prunus Mume Fruit Extract, Whey Lactis Proteine Du Petit-Lait Protein, Gelidium Cartilagineum Extract, Glycerin, Coenzyme A, Micrococcus Lysate, Laminaria Digitata Extract, Rosmarinus Officinalis Extract Rosemary Extract, Laminaria Ochroleuca Extract, Punica Granatum Fruit Juice, Sorbitol, Corallina Officinalis Extract, Molasses Saccharum Officinarum Extrait De Melasse Extract, Glycine Soja Seed Extract Soybean Seed Extract, Tourmaline, Caffeine, Linolenic Acid, Hydrogenated Lecithin, Gold, Hydrolyzed Wheat Protein, Glycosaminoglycans, Palmitoyl Oligopeptide, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Bifida Lysate Ferment, Alcaligenes Polysaccharides, Butylene Glycol, Tetraacetylphytosphingosine, Dipotassium Glycyrrhizate, Lecithin, Acetyl Glucosamine, Sodium Hyaluronate, Laureth-23, Acetyl Hexapeptide-8, Linoleic Acid, Dipalmitoyl Hydroxyproline, Propylene Glycol Diethylhexanoate, Yeast Faex Extrait De Levure Extract, Caprylic Capric Triglyceride, Laureth-4, Tocopheryl Acetate, Diethylhexyl Syringylidenemalonate, Pentylene Glycol, Peg-8, Potassium Sorbate, Yeast Polysaccharides, Hydroxypropyl Cyclodextrin, Nordihydroguaiaretic Acid, Cyclodextrin, Maltodextrin, Sucrose, Glyceryl Polymethacrylate, Parfum, Polymethylsilsesquioxane, Silica, Ethylbisiminomethylguaiacol Manganese Chloride, Disodium Edta, Phenoxyethanol, Linalool, Hydroxycitronellal, Citronellol, Geraniol, Limonene, Green 5 Ci 61570

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.