La Mer The Essential Tonic for dry skin

How to apply

Questions and answers

What the research says

• A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies.

  International Journal of Cosmetic Science, 2026

• Topical myristyl nicotinate increased skin cell NAD, stratum corneum thickness, epidermal thickness, epidermal renewal, minimal erythemal dose, and barrier resistance while reducing transepidermal water loss in subjects with photodamaged skin compared to placebo.

  Experimental Dermatology, 2007

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction.

  Journal of Cosmetic Dermatology, 2024

• Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery.

  Journal of Cosmetic Dermatology, 2023

• Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir.

  Frontiers in Microbiology, 2020

• Topical application of sesame oil combined with standard care significantly reduced infusion-related phlebitis in adults compared to a control condition, with a risk ratio of 0.54.

  Complementary Therapies in Medicine, 2025

• Sesamol loaded silver nanoparticles gel showed a twofold increase in skin permeation and higher antioxidant activity compared to conventional formulations, demonstrating potential for topical wound healing delivery.

  Current Pharmaceutical Design, 2024

• Treatment with moderately ozonated sesame oil accelerates cutaneous wound closure and enhances cell response, angiogenesis, and VEGF and cyclin D1 expression in SKH1 mice compared to oil with lower or higher peroxide values and controls.

  Wound Repair and Regeneration, 2011

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

Ingredients

Declustered Water, Water, Eau De-Structuree, Methyl Gluceth-20, Glycereth-26, Laminaria Digitata Extract, Algae Extract, Sesamum Indicum Seed Oil, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Butylene Glycol, Ppg-28-Buteth-35, Ppg-5-Ceteth-20, Sodium Hyaluronate, Citric Acid, Sodium Citrate, Polysorbate 20, Sucrose, Caffeine, Disodium Edta, Benzophenone-4, Phenoxyethanol, Potassium Sorbate, Parfum, Linalool, Yellow 5 Ci 19140, Red 33 Ci 17200

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.