# ISDIN Retinal Intense Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [ISDIN](https://lovi.care/skincare/de/brands/isdin)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for normal skin with niacinamide and retinaldehyde, which provide antioxidant activity and regulate desquamation, but these ingredients are not specialized for your redness and irritation concerns.
- The formulation includes Tocopherol and Retinaldehyde, which are beneficial for anti-aging and general skin health, but may not directly address your primary concerns of redness and irritation.
- The product is safe for your sensitive skin, as it lacks harsh ingredients and contains soothing components like Niacinamide and Tocopherol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Retinaldehyde, Niacinamide, Bakuchiol, Tocopherol, Palmitoyl Tetrapeptide-7

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Based on limited data, users highly praise this biphasic night serum for its ability to smooth skin texture and soften fine lines, with many noting it's gentle and non-irritating, even for sensitive skin. While most users experience positive anti-aging results and appreciate its elegant texture, some find the price point to be high and a few report a short shelf life or slow results for deeper wrinkles.

- Liked: Gentle & non-irritating (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Elegant texture (sometimes noted)
- Liked: Visible anti-aging (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Initial mild irritation (rarely noted)
- Disliked: Short shelf life (rarely noted)
- Disliked: Slow results for some (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does ISDIN Retinal Intense work for sensitive skin?

This product works for sensitive skin, though other products fit it better because its ingredients are not specialized for redness and irritation. It is safe since it lacks harsh ingredients and contains soothing components, but sensitive skin needs products that specifically target redness and irritation with soothing, skin-repairing ingredients.

### Which ingredients make this serum a good fit for sensitive skin?

Niacinamide, tocopherol, and retinaldehyde make this serum a fit for sensitive skin by offering gentle antioxidant benefits and general support, though a product for this skin needs extra soothing and calming ingredients to target redness and irritation directly.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Retinal do for sensitive skin?

Retinal helps smooth fine lines, improve texture, and even out skin tone while generally maintaining a good tolerance profile with a lower likelihood of irritation compared to stronger forms of vitamin A.
Sources: [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39496127/), [Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473963/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Sensitive skin needs a treatment that includes calming ingredients and gentle barrier-repairing agents to keep the skin comfortable while using active ingredients.

### Can I use this serum with AHA, and in what order?

It is best to avoid using this serum in the same routine as an AHA, as combining strong treatments may easily trigger redness and irritation on sensitive skin. Instead, alternate them on different nights or use your AHA in the morning and this serum at night, always following with a soothing moisturizer.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum works for your sensitive skin in the evening, though other products fit it better. It is safe for you because it lacks harsh ingredients and includes soothing components like Niacinamide and Tocopherol, but a product for this skin needs extra calming and barrier-repairing ingredients to properly manage redness and irritation.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, but the retinaldehyde in it may cause some initial mild peeling or purging as your skin adjusts. A product for this skin needs soothing and calming ingredients like niacinamide and vitamin E to keep irritation low.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

- Amazon.de: €59.55 (https://www.amazon.de/dp/B0BD9DK6SC?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dimethicone, Dibutyl Adipate, Niacinamide, Isoamyl Laurate, Lauryl Peg Ppg-18 18 Methicone, Glycerin, Propanediol, Dimethicone Vinyl Dimethicone Crosspolymer, Alcohol Denat, Bakuchiol, 2-Hexanediol, Pentylene Glycol, Caprylic Capric Triglyceride, Ethylcellulose, Hydroxyacetophenone, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-T-Butylcyclohexanol, Caprylyl Glycol, Parfum, Sodium Acrylates Crosspolymer-2, Polyacrylate Crosspolymer-6, Vigna Aconitifolia Seed Extract, Tocopheryl Acetate, Tocopherol, Citric Acid, Xanthan Gum, Maltodextrin, Melatonin, Retinal Retinaldehyde, Silica, Disodium Edta, Synthetic Fluorphlogopite, Ci 77891 Titanium Dioxide, Ascorbic Acid, T-Butyl Alcohol, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Palmitoyl Tetrapeptide-7, Tin Oxide, Chrysin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isdin/retinal-intense-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/isdin/retinal-intense-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/isdin/retinal-intense-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/isdin/retinal-intense-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/isdin/retinal-intense-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/isdin/retinal-intense-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/isdin/retinal-intense-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/isdin/retinal-intense-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/isdin/retinal-intense-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isdin/retinal-intense-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isdin/retinal-intense-serum/for/sensitive-skin