# iS Clinical Active Serum for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/is-clinical/active-serum/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [iS Clinical](https://lovi.care/skincare/de/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Offers excellent treatment for acne and uneven skin tone on your oily skin due to Saccharum Officinarum Extract and Vaccinium Myrtillus Leaf Extract providing effective chemical exfoliation.
- The presence of Willow Bark Extract further aids in skin renewal, making it highly suitable for managing oiliness.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/is-clinical/active-serum/for/oily-acne-prone-skin): High

## Key ingredients

Saccharum Officinarum Extract, Vaccinium Myrtillus Extract, Arbutin, Willow Bark Extract, Polyporus Umbellatus Extract Mushroom Extract

## What the research says

- Combined sequential treatment with microneedling and 35% glycolic acid peels caused a significant improvement in superficial and moderately deep acne scars, skin texture, and postacne pigmentation in thirty patients compared to thirty patients receiving microneedling alone. ([Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151943/))
- A combination of dermapen and glycolic acid peel significantly decreased acne scar grades and resulted in higher patient satisfaction compared to either monotherapy in 30 patients. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30548170/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- A novel emulsion containing niacinamide, lens esculenta seed extract, and white willow bark extract effectively improved acne, blackheads, and conspicuous facial pores in 30 subjects with oily skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38140770/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## What reviewers say

Users consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.

- Liked: Clears Acne & Breakouts (mostly mentioned)
- Liked: Improves Texture & Tone (often mentioned)
- Disliked: High Price Point (often mentioned)
- Liked: Anti-Aging Benefits (sometimes noted)
- Liked: Fast Visible Results (sometimes noted)
- Disliked: Intense Tingling Sensation (sometimes noted)
- Disliked: Drying for Some (rarely noted)
- Disliked: Risk of Counterfeits (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes iS Clinical Active Serum a great fit for oily skin?

iS Clinical Active Serum is a great fit because it offers excellent treatment for acne and uneven skin tone on your oily skin through chemical exfoliation from Saccharum Officinarum Extract and Vaccinium Myrtillus Leaf Extract. The willow bark extract further helps with skin renewal and manages oiliness safely without irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151943/)

### Which ingredients make this serum a good fit for oily skin?

Saccharum Officinarum Extract and Vaccinium Myrtillus Leaf Extract make this serum a great fit by providing effective chemical exfoliation for acne and uneven skin tone on oily skin. Willow Bark Extract further helps with skin renewal to manage oiliness, and the formula is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151943/)

### What does Sugarcane Extract do for oily skin?

Sugarcane extract is a natural source of glycolic acid that helps clear dead skin and excess oil from pores to keep oily skin smooth and clear. This type of ingredient exfoliates the skin while helping maintain moisture balance, making it a good fit for managing shine and breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/), [The British Journal of Dermatology, 2001](https://pubmed.ncbi.nlm.nih.gov/11251557/)

### What does Bilberry Fruit Extract do for oily skin?

Bilberry fruit extract helps oily skin by using its natural plant compounds to reduce redness and manage skin pigment. This ingredient is generally well tolerated, though a lightweight formula is best to avoid feeling heavy on oily skin.
Sources: [Pakistan Journal of Pharmaceutical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34602422/)

### Where does this serum go in a skincare routine for oily skin?

This treatment serum goes in your evening routine after cleansing and toning, and before moisturizing. Start by using it once a week, and if your oily skin handles it well, you can carefully use it more often.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying them on alternate nights to prevent irritation on oily skin. Using them together may be too harsh since both ingredients actively renew the skin.

### How often should I use this serum?

Start by using this treatment once a week in the evening, and if your oily skin tolerates it well and shows good results, you may carefully use it more often. It helps clear acne and uneven skin tone while managing oiliness safely without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to clog pores or cause breakouts on your oily skin because it contains ingredients that provide effective chemical exfoliation and manage oiliness without irritation. It has a great safety profile for oily skin, though an intense tingling sensation may sometimes happen.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151943/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — €9.99 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — €35.29 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — €169.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — €16.59 at Amazon
- Moisturizer: [CeraVe CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/de/p/cerave/pm-facial-moisturizing-lotion/for/oily-skin) — Superior fit — €38.99 at Amazon

## Where to buy

- Amazon.de: €113.00 (https://www.amazon.de/dp/B0073RK3S2?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/active-serum/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/active-serum/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/active-serum/for/oily-skin (this page)
- France: https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/active-serum/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/active-serum/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/active-serum/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/active-serum/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/active-serum/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/oily-skin