# IOPE Pro Peeling Enzyme Wash for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [IOPE](https://lovi.care/skincare/de/brands/iope)
Category: [Exfoliants](https://lovi.care/skincare/de/best/exfoliators)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few products fit it even better.

## Why this fit

- Offers excellent exfoliation for your oily skin and acne concerns, as papain and protease effectively break down dead skin cells and excess sebum, while lemon fruit extract and saccharum officinarum extract aid in desquamation regulation.
- The inclusion of lipase further supports oil breakdown, complementing the keratolytic action for smoother texture.
- This formula is safe for your skin, with allantoin providing soothing benefits and no harsh ingredients present.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Papain, Squalane, Acetyl Glucosamine, Betaine, Vaccinium Myrtillus Fruit Extract

## What the research says

- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/))
- Combined sequential treatment with microneedling and 35% glycolic acid peels caused a significant improvement in superficial and moderately deep acne scars, skin texture, and postacne pigmentation in thirty patients compared to thirty patients receiving microneedling alone. ([Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151943/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))

## What reviewers say

Based on limited data, users find this enzyme wash effectively exfoliates and smooths skin, leaving it feeling soft and clean without dryness, making it suitable for sensitive skin. However, the product is considered expensive for the quantity provided, and the powder format can lead to clumping and dispensing difficulties.

- Liked: Improved skin texture (mostly mentioned)
- Liked: Gentle exfoliation (often mentioned)
- Liked: Non-stripping cleanse (often mentioned)
- Disliked: Expensive for amount (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Effective deep clean (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your enzyme powder cleanser PM once a week to start, then increase frequency if your skin tolerates it well. Always apply SPF during the day since exfoliating products can make skin sensitive to the sun.
- Apply this enzyme powder cleanser in your weekly routine after the standard cleanser and before your hydrating toner and moisturizer. This step helps clear away dead skin cells.
- Mix the powder with a little water in your hands to create a gentle foam , then massage it softly onto your face while avoiding harsh rubbing.
- Apply the enzyme powder cleanser on slightly damp skin to help activate the formula effectively. Make sure your face is clean from makeup before starting.
- Avoid the delicate eye area and do a patch test before your first use. Do not mix this with strong acids or retinoids in the same routine to prevent irritation.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes IOPE Pro Peeling Enzyme Wash a great fit for oily acne-prone skin?

IOPE Pro Peeling Enzyme Wash is a great fit because papain, protease, and lipase effectively break down dead skin cells and excess oil to keep your skin smooth and clear. It also has allantoin, which helps calm your skin safely without any harsh ingredients.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/)

### Which ingredients make this cleanser a good fit for oily acne-prone skin?

Papain, protease, and lipase make this cleanser a great fit because they break down dead skin cells and excess oil to keep your skin smooth and clear. Lemon fruit extract helps remove buildup, while allantoin keeps your skin calm and comfortable.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### What does Papain do for oily acne-prone skin?

Papain helps clear oily acne-prone skin by gently exfoliating the surface and breaking down dead skin cells that can clog pores. This gentle smoothing action may reduce breakouts and blemishes, though some people might experience mild irritation as the skin adjusts.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [International Journal of Cosmetic Science, 2022](https://pubmed.ncbi.nlm.nih.gov/35892222/)

### What does Squalane do for oily acne-prone skin?

Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### Where does it go in a skincare routine for oily acne-prone skin?

This enzyme powder cleanser fits into a weekly routine for oily acne-prone skin, starting at once a week and cautiously increasing if your skin tolerates it well. It helps clear dead skin cells and excess oil for a smoother texture.

### Can I use this cleanser with retinol, and in what order?

You can use this enzyme powder cleanser weekly as part of your routine, but avoid using it on the same nights you apply retinol to prevent irritation. Using them on separate days helps keep your oily skin smooth and clear while keeping your safety profile strong.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### How often should I use it?

Start by using this enzyme powder once a week as a weekly step in your routine. People who tolerate it well and see good results can carefully use it more often.

### Can this cleanser clog pores, cause breakouts or purging for oily acne-prone skin?

This cleanser is a great fit for your oily, acne-prone skin because its enzymes effectively clear away dead skin cells and excess oil for a smooth texture, while soothing ingredients help calm potential irritation. It is unlikely to clog pores or cause breakouts, and any mild purging may happen as it clears your skin.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/)

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (ethanol).

## Alternatives for oily acne-prone skin

- [NEEDLY Mild Enzyme Cleansing Powder](https://lovi.care/skincare/de/p/needly/mild-enzyme-cleansing-powder/for/oily-acne-prone-skin) — High fit — €37.40 at Amazon
- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/de/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/oily-acne-prone-skin) — High fit — €17.32 at Amazon
- [Fancl Deep Clear Washing Powder](https://lovi.care/skincare/de/p/fancl/deep-clear-washing-powder/for/oily-acne-prone-skin) — Average fit — €19.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/de/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/de/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/oily-acne-prone-skin) — Superior fit — €37.64 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Microcrystalline Cellulose, Sodium Cocoyl Glycinate, Sodium Lauroyl Glutamate, Silica, Papain, Protease, Lipase, Lemon Fruit Extract, Saccharum Officinarum Extract, Sugar Maple Extract, Vaccinium Myrtillus Fruit Extract, Citrus Aurantium Dulcis Fruit Extract, Betaine, Squalane, Acetyl Glucosamine, Allantoin, Chitosan, Alpha-Glucan Oligosaccharide, Ethyl Cellulose, Ethanol, Xanthan Gum, Water, Butylene Glycol, Polycaprolactone, Peg-75, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin