# HISTOLAB Soft Deep Cleansing Enzyme Powder Wash for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: HISTOLAB
Category: [Exfoliants](https://lovi.care/skincare/de/best/exfoliators)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few products fit it even better.

## Why this fit

- Offers excellent cleansing for your combination skin, as Sodium Lauroyl Glutamate and Sodium Cocoyl Isethionate effectively remove impurities and excess oil from pores. Papain and bromelain provide moderate enzymatic exfoliation, which helps manage oiliness and promotes smoother skin, though it may not be specialized enough for severe acne.
- Allantoin and Tocopherol Vitamin E offer soothing benefits, minimizing irritation potential for your acne-prone skin.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/oily-acne-prone-skin): High

## Key ingredients

Papaya Enzyme, Rice Powder, Baking Soda, Camellia Sinensis Extract, Ascorbic Acid

## What the research says

- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Sodium cocoyl isethionate micelles are too large to penetrate stratum corneum aqueous pores, resulting in significant steric hindrance that prevents skin barrier perturbation and explains its skin mildness. ([Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/))
- Topical application of (-)-epigallocatechin-3-gallate (EGCG) to human skin before UV irradiation decreases UV-induced production of hydrogen peroxide by 68-90% and nitric oxide by 30-100%, inhibits leukocyte infiltration and lipid peroxidation by 41-84%, and restores glutathione levels and glutathione peroxidase activity compared to UV exposure alone. ([Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/))
- Application of green tea extracts on normal human skin resulted in dose-dependent inhibition of UV-evoked erythema, reduced sunburn cells, protected Langerhans cells, and decreased UV-induced DNA damage compared to untreated UV-exposed skin. ([Journal of the American Academy of Dermatology, 2001](https://pubmed.ncbi.nlm.nih.gov/11209110/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Daily application of a cream containing niosomes loaded with purple glutinous rice extract in 20 human volunteers for 28 days resulted in a significant decrease in melanin index and skin roughness by -14.05% and -9.95%, and increases in skin hydration and elastic recovery by +48.73% and +35.98% compared to initial values. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32812663/))
- The iontophoretic delivery of hyaluronic acid nanogel-loaded Saccharomyces/Rice Ferment Filtrate significantly reduced advanced glycation end products and mitigated skin stiffening in an ex vivo skin tissue glycation model. ([International Journal of Nanomedicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40989892/))
- Red rice extract suppressed UVB-induced inflammation and skin aging in human skin fibroblasts by inhibiting the MAPK signaling pathway, leading to decreased NF-kappa B and AP-1 activation, reduced ECM degradation, and increased ECM synthesis compared to UVB-irradiated controls. ([Natural Product Communications, 2016](https://pubmed.ncbi.nlm.nih.gov/30508356/))
- Oral sodium bicarbonate improved Yo-Yo IR2 distance by 21% and repeated sprint completion time by 1.9%, while topical sodium bicarbonate improved repeated sprint time by 2.0% without affecting Yo-Yo IR2 distance, in recreationally trained male athletes compared to placebo. ([Journal of the International Society of Sports Nutrition, 2023](https://pubmed.ncbi.nlm.nih.gov/37227399/))
- Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction. ([Journal of Clinical and Diagnostic Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28384900/))
- Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo. ([Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## What reviewers say

Based on limited available data, users find this enzymatic cleanser to be gentle and effective, leaving skin soft and smooth without stripping natural oils. It is particularly beneficial for oily and acne-prone skin, helping to manage sebum and unclog pores. Some users note a learning curve for lathering the powder format.

- Liked: Gentle Exfoliation (often mentioned)
- Liked: Travel-Friendly (often mentioned)
- Liked: Good for Oily/Acne Skin (sometimes noted)
- Liked: Post-Wash Feel (sometimes noted)
- Disliked: Lathering difficulty (sometimes noted)
- Disliked: Availability (rarely noted)
- Disliked: Price & Size (rarely noted)
- Disliked: Scent (rarely noted)

## How to apply

- Use your enzyme powder cleanser as part of your PM weekly routine. Start by using it once a week and build up slowly if your skin is happy.
- Place this step after your regular cleanser and before applying your hydrating toner. Follow the weekly routine order for the best results.
- Mix the powder with a little water in your hands to create a soft foam. Gently massage onto your face and avoid rubbing too hard.
- Apply the enzyme powder cleanser on slightly damp skin to help activate the formula evenly. Make sure your face is clean before applying.
- Avoid the sensitive eye area during application. Do a patch test first and do not combine this with strong acids on the same night.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes HISTOLAB Enzyme Powder Wash a great fit for acne-prone skin?

HISTOLAB Soft Deep Cleansing Enzyme Powder Wash is a great fit for acne-prone skin because it gently clears away excess oil and impurities while providing mild enzymatic exfoliation to keep skin smooth. Soothing ingredients like allantoin and vitamin E help keep irritation low, giving it an excellent safety profile for sensitive or breakout-prone skin.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### Which ingredients make this cleanser a good fit for acne-prone skin?

Sodium Lauroyl Glutamate and Sodium Cocoyl Isethionate make this cleanser a great fit by washing away pore-clogging oil, while papain and bromelain gently smooth the skin. Allantoin and vitamin E help calm irritation, making it very safe for your skin type.
Sources: [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### What does Papaya Enzyme do for acne-prone skin?

Papaya enzyme gently removes dead surface buildup to help clear pores and smooth out rough texture. It helps keep skin calm and is unlikely to cause irritation when used as directed.
Sources: [Archives of Dermatological Research, 2001](https://pubmed.ncbi.nlm.nih.gov/11820726/)

### What does Rice Powder do for acne-prone skin?

Rice Powder helps absorb excess oil and calms dry, irritated areas while being very unlikely to irritate acne-prone skin. It supports a smooth, clear look by keeping shine under control without clogging pores.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35587098/), [International Journal of Toxicology, 2006](https://pubmed.ncbi.nlm.nih.gov/17090480/)

### Where does this cleanser go in a skincare routine for acne-prone skin?

This enzyme powder cleanser is used once a week in your weekly routine step. It helps remove impurities and excess oil while keeping your skin calm and smooth.

### Can I use this cleanser with retinol, and in what order?

You can use this enzyme powder cleanser alongside retinol, but since both can be active on your skin, it is best to use them on separate days or times to prevent irritation. Using this cleanser on your weekly routine day and your retinol on other nights helps keep your skin smooth while managing oiliness safely.

### How often should I use this cleanser?

This enzyme powder cleanser is a great fit for your acne-prone skin and is used once a week in the Lovi routine. People who tolerate this type of gentle exfoliation well and see good results can carefully use it more often.

### Can this cleanser clog pores, cause breakouts or purging for acne-prone skin?

This cleanser is a great fit for acne-prone skin because gentle cleansers like sodium lauroyl glutamate and sodium cocoyl isethionate effectively remove excess oil and impurities from pores without disrupting the skin barrier. Papain and bromelain provide light exfoliation that helps manage oiliness, while soothing ingredients like allantoin and vitamin E minimize irritation and keep skin calm. It is unlikely to clog pores or cause breakouts.
Sources: [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### Is this cleanser fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/de/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/acne-prone-skin) — High fit — €17.32 at Amazon
- [NEEDLY Mild Enzyme Cleansing Powder](https://lovi.care/skincare/de/p/needly/mild-enzyme-cleansing-powder/for/acne-prone-skin) — High fit — €37.40 at Amazon
- [Fancl Deep Clear Washing Powder](https://lovi.care/skincare/de/p/fancl/deep-clear-washing-powder/for/acne-prone-skin) — Average fit — €19.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €13.67 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Sodium Lauroyl Glutamate, Sodium Cocoyl Isethionate, Papain, Bromelain, Sodium Bicarbonate, Silica, Allantoin, Tocopherol Vitamin E, Ascorbic Acid, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/acne-prone-skin