# Goldfaden MD Radical Difference for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Goldfaden MD](https://lovi.care/skincare/de/brands/goldfaden-md)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry skin due to the presence of sodium hyaluronate for humectant action and Lactobacillus Acerola Cherry Ferment for antioxidant activity.
- Offers excellent skin hydration due to the presence of sodium hyaluronate in concentrations that provide plumping.
- The product is safe for your dry skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Aspalathus Linearis Extract, Lactobacillus Acerola Cherry Ferment, Saccharomyces Zinc Ferment, Saccharomyces Magnesium Ferment

## What the research says

- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Ginkgo formulation increased skin moisturization by 27.88% and smoothness by 4.32% while reducing roughness by 0.4% and wrinkles by 4.63%, and significantly improved skin moisturization compared to the tea and rooibos formula. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20412217/))
- The addition of Aspalathus linearis extracts to topical sunscreen formulas containing OMC and BMDBM increased protection factors by up to 50% and protected the filters against photodegradation under radiation doses up to 14.4 standard erythemal doses. ([Photochemical & Photobiological Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/41591727/))
- The combination of fermented and unfermented Aspalathus linearis extracts showed a synergistic photoprotective effect on Normal Human Dermal Fibroblast survival after UVB radiation, which further improved when combined with Polypodium leucotomos extract. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40076948/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Radical Difference a great fit for dry skin?

Goldfaden MD Radical Difference is a great fit for dry skin because it contains sodium hyaluronate to draw in moisture and plump the skin, along with cherry ferment to provide antioxidant benefits. It is also safe and unlikely to cause irritation since it lacks harsh ingredients.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for your dry skin thanks to sodium hyaluronate, which draws in moisture to keep your skin plump and hydrated. It also includes Lactobacillus Acerola Cherry Ferment, which helps protect your skin with antioxidants.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Roobos Extract do for dry skin?

Rooibos extract helps soothe dry skin and protects it against damage from the sun and everyday stress. It provides antioxidants that keep your skin feeling calm and smooth.
Sources: [Molecules, 2016](https://pubmed.ncbi.nlm.nih.gov/27706097/)

### Where does it go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before your moisturizer. It is a great fit for your dry skin because sodium hyaluronate brings moisture and plumping while antioxidant ingredients help protect against daily stress without causing irritation.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the treatment in your evening routine after cleansing and before your moisturizer. It is very safe for dry skin and is unlikely to cause irritation.

### How often should I use it?

This treatment is used in your evening routine, applying it after cleansing and before your moisturizer. It is very safe for dry skin and is unlikely to cause irritation.

### Can Radical Difference clog pores, cause breakouts or purging for dry skin?

Goldfaden MD Radical Difference is unlikely to clog pores or cause breakouts for dry skin because it has no harsh ingredients that trigger irritation. It relies on sodium hyaluronate to keep your skin smooth and hydrated safely.
Sources: [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €9.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/de/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/de/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — €19.75 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/de/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — €12.59 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/de/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Hyaluronate, Aspalathus Linearis Extract, Lactobacillus Acerola Cherry Ferment, Saccharomyces Zinc Ferment, Saccharomyces Magnesium Ferment, Saccharomyces Iron Ferment, Saccharomyces Silicon Ferment, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/goldfaden-md/radical-difference/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/goldfaden-md/radical-difference/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/goldfaden-md/radical-difference/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/goldfaden-md/radical-difference/for/dry-skin (this page)
- France: https://lovi.care/skincare/fr/p/goldfaden-md/radical-difference/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/goldfaden-md/radical-difference/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/goldfaden-md/radical-difference/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/goldfaden-md/radical-difference/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/goldfaden-md/radical-difference/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/goldfaden-md/radical-difference/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/goldfaden-md/radical-difference/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/goldfaden-md/radical-difference/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/goldfaden-md/radical-difference/for/dry-skin