# DRMTLGY Peptide Night Cream for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [DRMTLGY](https://lovi.care/skincare/de/brands/drmtlgy)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as ceramides and peptides enhance barrier resilience and glycerin provides hydration, but it lacks targeted ingredients for your acne and blemishes.
- Shea butter offers emollient actions, which are supportive for acne-prone skin, but the formula does not provide sufficient ingredients for optimal oil control.
- The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptides, Ceramides, Shea Butter, Tocopherol Vitamin E, Allantoin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Based on a very large amount of data, this fragrance-free night cream is highly regarded for its rich yet non-greasy texture, providing deep hydration and plumping effects. Users frequently report improvements in skin texture, reduced fine lines, and a strengthened moisture barrier, making it suitable for sensitive and aging skin types. Some users find the jar packaging unhygienic, and a few with very dry skin may require additional moisture, while others note it can be too heavy for daytime use. Availability can also be a concern due to frequent sell-outs.

- Liked: Deep hydration (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Non-greasy texture (often mentioned)
- Liked: Anti-aging benefits (sometimes noted)
- Liked: Value for money (sometimes noted)
- Disliked: Jar packaging (sometimes noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Not rich enough (rarely noted)
- Disliked: Too heavy for day (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does DRMTLGY Peptide Night Cream work for acne-prone skin?

This cream works moderately for acne-prone skin because it hydrates and strengthens the skin barrier with glycerin and ceramides, but it lacks targeted ingredients for breakouts and oil control. Acne-prone skin needs a moisturizing treatment that provides effective ingredients for blemishes and breakouts alongside soothing agents and hydration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for acne-prone skin?

Ceramides, peptides, and glycerin make this cream a good fit by strengthening the skin barrier and providing hydration, while shea butter offers softening benefits. However, because acne-prone skin needs more, this type of product also requires targeted ingredients for oil control and blemishes.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Peptides do for acne-prone skin?

Peptides help calm acne-prone skin by reducing redness and soothing inflammation while supporting the skin barrier. Certain advanced peptide formulas also work to target acne-causing bacteria and help balance oil production.
Sources: [Biochemical Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39662606/), [Bioresources and Bioprocessing, 2026](https://pubmed.ncbi.nlm.nih.gov/42219443/)

### What do Ceramides do for acne-prone skin?

Ceramides help acne-prone skin by restoring a damaged water barrier, reducing dryness and redness from acne treatments, and lowering inflammation. Because acne-prone skin often lacks these key fats, products for this skin type need ceramides to soothe irritation and keep the barrier strong.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [Archives of Dermatological Research, 1995](https://pubmed.ncbi.nlm.nih.gov/7763094/)

### Where does it go in a skincare routine for acne-prone skin?

This product goes in the evening routine as a moisturizing treatment after your cleanser and toner. For acne-prone skin, this cream works well enough, but it lacks targeted ingredients for blemishes, so this skin needs added blemish-fighting ingredients and oil-control components.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following it with this moisturizer. This helps keep your skin soft while managing dryness, though acne-prone skin needs a product that also provides targeted oil control and blemish-fighting ingredients.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this moisturizing treatment twice daily to help keep your skin hydrated and support your skin barrier. This product is unlikely to irritate your skin, though acne-prone skin needs a product with targeted ingredients for blemishes and oil control.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to cause irritation or breakouts since it lacks harsh ingredients, but it does not provide enough oil control for acne-prone skin. Acne-prone skin works best with products that offer targeted blemish control and oil-balancing ingredients.

### Can I use it around the eyes or on my body?

This cream is safe to use around the eyes and on the body, as it has a very gentle formula with no harsh ingredients. However, because the skin around the eyes is very thin and body skin is thicker, you may want to choose products specifically designed for those areas to get the best results.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €13.67 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/de/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — €36.14 at Amazon
- [ANUA Heartleaf 70% Soothing Cream](https://lovi.care/skincare/de/p/anua/heartleaf-70-soothing-cream/for/acne-prone-skin) — High fit — €25.95 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/de/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — €65.41 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter Shea Butter, Caprylic Capric Triglyceride, Cetyl Alcohol, Dimethicone, Peg-100 Stearate, Ceramide Eop, Ceramide Ap, Palmitoyl Tetrapeptide-7, Ceramide Np, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium Edta, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drmtlgy/peptide-night-cream/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/drmtlgy/peptide-night-cream/for/acne-prone-skin