# Dear, Klairs Midnight Blue Youth Activating Drop for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Dear, Klairs](https://lovi.care/skincare/de/brands/dear-klairs)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- This product offers excellent skin rejuvenation for your combination skin, as Sh-Oligopeptide-1 and Sh-Polypeptide-1 promote extracellular matrix synthesis to minimize fine lines and wrinkles.
- The inclusion of blueberry fruit extract and Guaiazulene further supports skin regeneration and healing, addressing your concerns with acne, blemishes, and breakouts.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin): High

## Key ingredients

Rh-Oligopeptide-1, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Guaiazulene

## What the research says

- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- Topical application of PTD-EGF and FGF1 increased cell proliferation and collagen accumulation while protecting against UV-induced damage and improving wrinkle parameters in human skin. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305427/))
- Basic fibroblast growth factor-loaded human serum albumin nanoparticles enhanced the proliferation and migration of human dermal fibroblasts, down-regulated myofibroblast-related genes, and accelerated wound healing with enhanced angiogenesis in vivo compared to unstable native forms. ([Journal of Nanobiotechnology, 2023](https://pubmed.ncbi.nlm.nih.gov/37658367/))
- Topical application of basic fibroblast growth factor decreases elevated transepidermal water loss and increases Ki67 expression in keratinocytes following mechanical scratching in a mouse model. ([Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23108135/))
- Applying a topical product containing blueberry extract and Pro-xylane following micro-focused ultrasound significantly improved global aesthetic improvement, skin elasticity, and fine lines compared to standard moisturizer in 50 patients. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40635529/))
- Topical usage of blueberries may prevent skin damage from environmental stressors by inducing an active skin response against noxious effects. ([Antioxidants, 2023](https://pubmed.ncbi.nlm.nih.gov/37371992/))
- Pretreatment with blueberry extracts prevented ozone-induced ROS production, NLRP1-ASC scaffold formation, and CASP1 and IL-18 transcripts across 2D, 3D, and human skin explant models. ([Oxidative Medicine and Cellular Longevity, 2020](https://pubmed.ncbi.nlm.nih.gov/32855770/))

## What reviewers say

Based on a very large amount of data, this product is widely praised as a lightweight, watery anti-aging serum that absorbs instantly and is exceptionally gentle, making it a favorite for oily and sensitive skin types. Many users report smoother skin texture, reduced redness, and a plump feel. Some find the 20ml bottle too small for the price and note that its preventative anti-aging effects take time to become visible.

- Liked: Rapid absorption (mostly mentioned)
- Disliked: Small volume/price (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Soothing & calming (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Not moisturizing (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes the Klairs Midnight Blue Youth Activating Drop a great fit for acne-prone skin?

This product is a great fit because blueberry fruit extract and Guaiazulene help soothe and heal acne, blemishes, and breakouts. It has a very safe formula with no harsh ingredients, so it is unlikely to cause irritation on sensitive or breakout-prone skin.
Sources: [Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/)

### Which ingredients make this serum a good fit for acne-prone skin?

Blueberry fruit extract and Guaiazulene make this serum a great fit for acne-prone skin by helping with regeneration and healing for breakouts. They are joined by soothing ingredients that give it a very safe profile without harsh components that might cause irritation.
Sources: [Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/)

### What does EGF do for acne-prone skin?

EGF helps calm acne-prone skin by reducing both inflamed and non-inflamed breakouts. It supports skin healing and barrier repair, making it a useful option for improving overall skin texture.
Sources: [International Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24962549/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum is used in the evening routine. Applying it at night provides extra safety around sun exposure, and its soothing ingredients are unlikely to cause irritation on acne-prone skin.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol once it absorbs. This product has an excellent safety profile with soothing ingredients that help calm the skin, making it unlikely to cause irritation when paired with active routines.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is very unlikely to irritate acne-prone skin because it avoids harsh ingredients and features soothing components.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit and is unlikely to clog pores, cause breakouts, or lead to purging on acne-prone skin. It features soothing components and has an excellent safety profile with no harsh ingredients that typically cause irritation.
Sources: [Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €9.99 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.29 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €169.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €13.67 at Amazon

## Where to buy

- Amazon.de: €21.78 (https://www.amazon.de/dp/B071GQP892?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €25.50 (https://www.notino.de/klairs/midnight-blue-aktivierendes-serum-zur-verjuengung-der-haut/p-16397531/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Butylene Glycol, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Lecithin, Sorbitan Sesquioleate, 1,2-Hexanediol, Caprylyl Glycol, Peg-60 Hydrogenated Castor Oil, Glycerin, Chlorphenesin, Guaiazulene, Ethylhexylglycerin, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin