Caudalie Premier Cru The Cream for combination skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Profhilo gel combined with Dysport Botox significantly improved skin hydration, skin thickness, and GAIS scores compared to Dysport Botox injection alone in 19 participants seeking neck rejuvenation.

  Dermatologic Therapy, 2022

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Grapeseed oil-loaded dermocosmetic nanoemulgel applied on the cheeks of healthy volunteers significantly reduced skin melanin, erythema, sebum production, and pores while increasing moisture and elasticity compared to a placebo.

  Journal of Cosmetic Dermatology, 2022

• Topical treatment with cranberry oil and grape oil improved wound healing in rats, with cranberry oil showing an 88.1% wound area reduction and grape oil showing 84.6% compared to 74.1% in controls and 78.4% in the mupirocin standard group on day 13.

  Phytotherapy Research, 2011

• An ionic liquid-based grapeseed oil emulsion increased transdermal penetration by 4.63-fold and improved skin hydration, firmness, elasticity, and facial wrinkles after 28 days of continuous use compared to ordinary emulsion.

  Pharmaceuticals, 2024

• A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.

  Journal of Cosmetic Dermatology, 2015

• Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

  Journal of Cosmetic Dermatology, 2026

• Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.

  International Journal of Cosmetic Science, 2026

Ingredients

Water, Butylene Glycol, Coco-Caprylate Caprate, Cetearyl Alcohol, Cetearyl Glucoside, Hydrolyzed Yeast Protein, Niacinamide, Octyldodecyl Myristate, Pentaerythrityl Distearate, Vitis Vinifera Seed Oil Grape Seed Oil, Butyrospermum Parkii Butter Extract Shea Butter Extract, Jojoba Esters, Potassium Cetyl Phosphate, Polyglycerin-3, Hydrolyzed Hyaluronic Acid, Glycerin, Palmitoyl Grapevine Shoot Extract, Palmitoyl Grape Seed Extract, Sodium Carboxymethyl Beta-Glucan, Acacia Decurrens Wax Flower, Helianthus Annuus Seed Oil Sunflower Seed Oil, Tocopherol, Helianthus Annuus Wax Seed Sunflower Wax Seed, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Parfum, Ethylhexylglycerin, Caprylyl Glycol, Pentylene Glycol, Ethylhexyl Palmitate, Carbomer, Potassium Sorbate, Xanthan Gum, Tribehenin, Sodium Phytate, Sorbitan Isostearate, Sodium Citrate, Arginine, Citric Acid, Lactic Acid, Ci 77891 Titanium Dioxide, Ci 77491 Iron Oxides, Ci 77492 Iron Oxides, Citronellol, Coumarin, Geraniol, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.