# Biotulin Supreme Skin Gel for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Biotulin](https://lovi.care/skincare/de/brands/biotulin)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for normal skin due to the humectant action of glycerin and sodium hyaluronate, complemented by the antioxidant properties of Vitis Vinifera Leaf Extract for visible anti-aging effects.
- The presence of Acmella Oleracea Extract and Sodium Hyaluronate offers excellent smoothing and plumping benefits, providing general hydration that supports redness and irritation.
- The product is safe for your sensitive skin, as it lacks any harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/oily-acne-prone-skin): Average

## Key ingredients

Acmella Oleracea Extract, Imperata Cylindrica Root Extract, Sodium Hyaluronate, Vitis Vinifera Leaf Extract Grape Leaf Extract, Spilanthol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- An all-natural anti-wrinkle emulsion serum containing Acmella oleracea extract demonstrated safe skin tolerability and reduced facial wrinkles in human volunteers after 2 weeks of application. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Treatment with methanolic extract of Acmella oleracea leaves exerted potent antioxidant, anti-inflammatory, antimicrobial, and wound healing effects in vitro by reducing inflammatory mediators, scavenging free radicals, inhibiting bacterial growth, and enhancing fibroblast migration without inducing cytotoxicity. ([Journal of Ethnopharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39357584/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A combination of Vitis vinifera shoot extract and a biotechnological extract demonstrated significant in vitro and in vivo antioxidant effects and improved clinical signs of photoaged skin in female subjects after a 4-week application. ([Journal of Drugs in Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17691204/))
- Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2020](https://pubmed.ncbi.nlm.nih.gov/32028189/))
- A water extract from grapevine leaves inhibited proinflammatory-induced interleukin-8 and vascular endothelial growth factor secretion in human keratinocytes compared to untreated challenged cells. ([Antioxidants, 2019](https://pubmed.ncbi.nlm.nih.gov/31100904/))

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biotulin Supreme Skin Gel a great fit for sensitive skin?

Biotulin Supreme Skin Gel is a great fit for sensitive skin because it lacks any harsh or prohibited ingredients that could cause irritation. Sodium hyaluronate and acmella oleracea extract offer excellent smoothing and plumping benefits, providing general hydration that supports redness and irritation.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this gel a good fit for sensitive skin?

Acmella oleracea extract and sodium hyaluronate make this gel a great fit because they smooth the skin and provide hydration that helps calm redness and irritation. The product is very safe for sensitive skin as it has no harsh ingredients that might cause a flare-up.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Acmella Oleracea Extract do for sensitive skin?

Acmella oleracea extract is unlikely to irritate sensitive skin and helps smooth out fine wrinkles while keeping the skin hydrated. This ingredient is generally well tolerated, but sensitive skin types still need gentle formulas that avoid harsh fragrances and common irritants.
Sources: [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/), [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/)

### What does Imperata Cylindrica Root Extract do for sensitive skin?

Imperata cylindrica root extract is unlikely to irritate sensitive skin, as it is generally well-tolerated in botanical formulations. However, because studies on this ingredient mostly focus on laboratory cell tests rather than human sensitive skin, it is important to patch test first.
Sources: [BioMed Research International, 2021](https://pubmed.ncbi.nlm.nih.gov/34708121/)

### Where does this gel go in a skincare routine for sensitive skin?

This treatment goes in your evening routine after your soothing toner and before your moisturizer. It is safe for sensitive skin because it lacks any harsh ingredients that could cause irritation.

### Can I use this gel with retinol, and in what order?

You can use this gel alongside retinol because it is safe for sensitive skin and lacks harsh ingredients that cause irritation. Apply your retinol first, wait for it to absorb, and then follow with this smoothing and hydrating gel.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this gel?

This treatment is used in the evening for sensitive skin. It helps provide hydration that supports redness and irritation without causing issues.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this gel clog pores, cause breakouts or purging for sensitive skin?

This gel is a great fit and is safe for your sensitive skin because it lacks any harsh ingredients that could cause irritation. It helps keep skin calm and hydrated without clogging pores or causing breakouts, making it very comfortable to use.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this gel fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Clarins Double Serum](https://lovi.care/skincare/de/p/clarins/double-serum/for/sensitive-skin) — High fit — €74.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol, Imperata Cylindrica Root Extract, Acmella Oleracea Extract, Xanthan Gum, Chondrus Crispus, Benzoic Acid, Phenoxyethanol, Vitis Vinifera Leaf Extract Grape Leaf Extract, Sodium Hyaluronate, Sodium Hydroxide, Carbomer, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Dehydroacetic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biotulin/supreme-skin-gel/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/biotulin/supreme-skin-gel/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/sensitive-skin
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- Spain: https://lovi.care/skincare/es/p/biotulin/supreme-skin-gel/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/biotulin/supreme-skin-gel/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/biotulin/supreme-skin-gel/for/sensitive-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/biotulin/supreme-skin-gel/for/sensitive-skin