# Biossance Squalane + Phyto-Retinol Serum for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Biossance](https://lovi.care/skincare/de/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry skin.

## Why this fit

- Excellent compatibility with your dry skin as squalane and glycerin provide superior hydration and emollient benefits, while bakuchiol and niacinamide work synergistically to smooth texture and minimize fine lines.
- The inclusion of sodium hyaluronate further enhances moisture retention, addressing your dry or flaky skin concerns effectively.
- The product is safe for your skin, containing no harsh ingredients and featuring soothing components like squalane and niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Bakuchiol, Niacinamide, Sodium Hyaluronate, Biosaccharide Gum-1

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users frequently report improvements in skin texture and significant hydration without the irritation commonly associated with retinoids. Some users find the name misleading and the scent polarizing, while others note the high price and recent availability issues.

- Liked: Gentle, non-irritating (mostly mentioned)
- Liked: Hydrating and moisturizing (often mentioned)
- Disliked: Availability issues (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Liked: Lightweight formula (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Misleading name (sometimes noted)
- Disliked: Polarizing scent (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biossance Squalane + Phyto-Retinol Serum one of the best fits for dry skin?

This serum is one of the best fits for dry skin because squalane and glycerin provide deep hydration and smooth out dry patches, while sodium hyaluronate helps lock in moisture. Additionally, bakuchiol and niacinamide work together to smooth your skin texture and soften fine lines without harshness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this serum a good fit for dry skin?

Squalane and glycerin make this serum a great fit for dry skin by delivering deep hydration, while sodium hyaluronate helps lock in that moisture to keep skin soft. Additionally, bakuchiol and niacinamide work together to smooth texture without causing the scaling or stinging sometimes linked to harsher options.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Squalane do for dry skin?

Squalane helps keep dry skin soft and smooth by acting as a hydrating agent that locks in moisture and prevents water loss. It is unlikely to cause irritation and may protect the skin from damage while improving overall hydration.
Sources: [Advances in Food and Nutrition Research, 2012](https://pubmed.ncbi.nlm.nih.gov/22361190/), [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/)

### What does Bakuchiol do for dry skin?

Bakuchiol helps soothe sensitive dry skin while keeping it soft and smooth. It improves skin moisture content and barrier function while reducing redness and irritation.
Sources: [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/), [Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346506/)

### Where does this serum go in a skincare routine for dry skin?

This treatment serum goes in your evening routine after cleansing and before moisturizing, which keeps things simple and safe. It works especially well for dry skin because it combines ingredients that lock in moisture and smooth texture without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40327583/)

### Can I use this serum with retinol, and in what order?

This serum already contains bakuchiol, a plant-based alternative that helps smooth texture and minimize fine lines similarly to retinol without the typical irritation. If you still want to use a separate retinol product, it is best to apply them on alternating nights rather than together to keep your dry skin calm and comfortable.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### How often should I use this serum?

Use this treatment serum in your evening routine. It is a great fit for your dry skin because ingredients like squalane, glycerin, and sodium hyaluronate provide deep moisture while bakuchiol and niacinamide smooth texture without harshness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin, as it features lightweight moisturizing ingredients like squalane and glycerin rather than heavy oils. Because it uses bakuchiol instead of traditional retinol, it also helps smooth texture without causing the active purging often linked to harsher treatments.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool, geraniol, and limonene).

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €9.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/de/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/de/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — €19.75 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/de/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — €12.59 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/de/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Water, Squalane, Glycerin, Niacinamide, Sodium Acrylates Copolymer, Bakuchiol, Sodium Hyaluronate, Rosa Canina Oil Fruit, Citrus Aurantium Amara Peel Oil, Biosaccharide Gum-1, Lecithin, Hexylene Glycol, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Sodium Gluconate, Citric Acid, Linalool, Geraniol, Limonene, Yeast Extract, Amino Acids, Tetrasodium Glutamate Diacetate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/dry-skin (this page)
- France: https://lovi.care/skincare/fr/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-phyto-retinol-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-phyto-retinol-serum/for/dry-skin