Biossance 100% Squalane Oil for oily acne-prone skin
Squalane- Squalane Oil
Average
- AverageOily Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for oily acne-prone skin; other products fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate moisturizing for your oily skin, as squalane provides emollient action to hydrate and enhance barrier resilience without significant oil control.
- While beneficial for general hydration, the formula lacks targeted ingredients to effectively address your acne, blemishes, and breakouts.
People Say
★4.7Overall rating based on 2.5k+ reviewsThis sugarcane-derived oil is widely praised as a "holy grail" for its lightweight, non-greasy texture that mimics the skin's natural moisture. Users with sensitive and acne-prone skin frequently report that it hydrates without clogging pores, while many appreciate its versatility as a multi-purpose treatment for face, body, and hair. This summary is based on a very large amount of data and should definitely be taken into account.
Highlights
Lightweight non-greasy Mostly Mentioned
- “soaks in right away”
- “doesn't feel heavy”
- “leaves a nice glow not grease”
- “feels like nothing on skin”
Multi-purpose versatility Often Mentioned
- “tames frizzy hair”
- “great on dry cuticles”
- “mixes well with foundation”
- “healed cracked elbows”
Softens skin texture Often Mentioned
- “skin feels like velvet”
- “plumps fine lines”
- “makes face super soft”
- “got rid of dry patches”
Soothing gentle Sometimes Noted
- “stopped the flaking”
- “no stinging on sensitive skin”
- “safe for fungal acne”
Packaging pump issues Sometimes Noted
- “pump leaks everywhere”
- “dispenses too much product”
- “messy cap”
- “bottle gets oily”
Caused breakouts Rarely Noted
- “gave me cystic acne”
- “caused tiny whiteheads”
- “clogged my pores”
- “rash appeared after use”
Insufficient hydration Rarely Noted
- “sat on top of skin”
- “still felt dry later”
- “needed a cream over it”
- “too thin for winter”
Price point Rarely Noted
- “pricy for just squalane”
- “The Ordinary is cheaper”
- “not worth the splurge”
- “paying for the brand”
Sources: lovi.care, biossance.com, sephora.ph, kohls.com, influenster.com, sephora.com, and more
Questions and answers
How well does Biossance Squalane Oil work for oily acne-prone skin?
Biossance Squalane Oil works moderately well for oily acne-prone skin by providing basic moisture and strengthening the skin barrier, but it lacks ingredients to target breakouts. An ideal product for this skin type needs lightweight hydrating ingredients, soothing extracts, and blemish-fighting agents to manage oil and clear breakouts without clogging pores.
Which ingredients make this oil a good fit for oily acne-prone skin?
Squalane makes this oil a moderate fit for oily skin by providing gentle hydration and strengthening your skin barrier without heavy oils. However, this product lacks targeted ingredients to address blemishes and breakouts. Oily acne-prone skin needs lightweight, non-clogging formulas with powerful acne-fighting ingredients, brightening agents, soothing extracts, peptides, and oil-controlling properties.
What does Squalane do for oily acne-prone skin?
Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
What does Squalane Oil do for oily acne-prone skin?
Squalane oil helps keep oily acne-prone skin soft and smooth without feeling heavy or greasy. Because it closely mimics your skin's natural oils, it is unlikely to clog pores, and it helps calm redness while supporting a balanced skin barrier.
Journal of Nanobiotechnology, 2025Journal of the American Academy of Dermatology, 2024
Where does this oil go in a skincare routine for oily acne-prone skin?
Biossance 100% Squalane Oil goes near the end of your morning or evening routine, right before sunscreen in the day or as your moisturizer step at night. Because it provides moderate hydration without oil control or blemish-fighting ingredients, an oily acne-prone skin type needs targeted blemish-clearing ingredients and lightweight hydrators instead.
Can I use this oil with retinol, and in what order?
You can use this oil with retinol by applying the oil after your retinol to help keep your skin soft and comfortable. This may reduce dryness and irritation while you use retinol, though a product of this type for oily acne-prone skin also needs targeted ingredients to clear breakouts.
How often should I use this oil?
You can use this oil daily to hydrate your oily skin, though an oily acne-prone skin needs a product with targeted blemish-clearing ingredients to better fit its specific needs.
Can this oil clog pores, cause breakouts or purging for oily acne-prone skin?
This oil is unlikely to clog pores since it has a light texture, but some users with oily acne-prone skin may experience breakouts because the formula lacks ingredients that target blemishes. A product for this skin needs oil-controlling and pore-clearing ingredients to keep breakouts away.
What the research says
Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate.
Scientific Reports, 2020Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities.
Journal of Nanobiotechnology, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025
Why other products fit oily acne-prone skin better
Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.
Journal of Cosmetic Dermatology, 2022
Ingredients
Squalane, Squalane Oil
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.