# Bioderma Hydrabio Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Bioderma](https://lovi.care/skincare/de/brands/bioderma)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your combination skin, this serum effectively hydrates with glycerin and sodium hyaluronate, while niacinamide helps regulate oil production, supporting your acne-prone skin without specialized breakout treatment.
- The formula provides excellent moisturizing benefits, plumping the skin and offering general skincare support that complements your needs.
- This product is safe for your skin, as it contains no harsh ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/oily-acne-prone-skin): High

## Key ingredients

Aquagenium Patent, Sodium Hyaluronate, Niacinamide, Glycerin, Laminaria Ochroleuca Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, gel-like texture that delivers deep hydration without leaving a sticky residue, making it ideal for dehydrated and sensitive skin. While most find it plumps and smooths the complexion effectively, those with extremely dry skin often note it works best when layered under a richer moisturizer rather than as a standalone solution.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Excellent makeup base (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Disliked: Fragrance presence (sometimes noted)
- Disliked: Price vs. size (sometimes noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Not enough for dry skin (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Bioderma Hydrabio Serum a great fit for acne-prone skin?

Bioderma Hydrabio Serum is a great fit because it hydrates with glycerin and sodium hyaluronate while niacinamide helps calm oily skin, keeping it smooth and soft. The formula has a safe and gentle profile that is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for acne-prone skin?

Glycerin and sodium hyaluronate hydrate your acne-prone skin, while niacinamide helps balance oil production. This combination gives your skin great moisture without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Aquagenium Patent do for acne-prone skin?

Aquagenium Patent helps acne-prone skin by boosting hydration and supporting moisture retention. This ingredient is designed to stimulate aquaporins, which are the skin's natural water channels, helping to keep skin balanced and comfortable. When dealing with acne-prone skin, a product of this type needs lightweight hydrators and barrier-strengthening ingredients that add moisture without clogging pores.
Sources: [Experimental Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31021014/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/39940752/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does it go in a skincare routine for acne-prone skin?

Bioderma Hydrabio Serum goes in the evening routine as a treatment step, applied after cleansing and before moisturizing. Niacinamide helps regulate oil production while glycerin and sodium hyaluronate keep your acne-prone skin hydrated and smooth without irritation.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin hydrated and help reduce dryness from the retinol. This gentle approach supports your skin barrier and is unlikely to cause irritation when combined with active treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use it?

This serum is a great fit for your acne-prone skin, as glycerin and sodium hyaluronate keep it hydrated while niacinamide helps manage oil. You can safely apply it in the evening as part of your routine to support your skin without causing irritation.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for your acne-prone skin because it hydrates with glycerin and sodium hyaluronate while niacinamide helps keep oil in check. It has a very safe formula that is unlikely to cause irritation or breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Can I use it around the eyes or on my body?

You can use this serum around the eyes and on the body because its gentle formula and hydrating ingredients are safe for delicate skin everywhere. Regular application in these areas helps keep your skin smooth and properly moisturized without causing irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum).

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €13.67 at Amazon
- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/de/p/revision-skincare/hydrating-serum/for/acne-prone-skin) — Superior fit — €237.70 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/de/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/acne-prone-skin) — High fit — €37.64 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/de/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — €65.41 at Amazon

## Where to buy

- Amazon.de: €21.49 (https://www.amazon.de/dp/B077GNPDX8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €25.90 (https://www.notino.de/bioderma/hydrabio-serum-gesichtsserum-fur-dehydrierte-trockene-haut/p-406040/)
- Lookfantastic: €29.33 (https://www.lookfantastic.de/p/bioderma-hydrabio-hyalu-face-serum-for-dry-dehydrated-skin-with-hyaluronic-acid-and-niacinamide-30ml/14939661/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Xylitol, Sodium Polyacrylate, Mannitol, Rhamnose, Fructooligosaccharides, Laminaria Ochroleuca Extract, Niacinamide, Pyrus Malus Fruit Extract, Dimethicone, Cyclopentasiloxane, Trideceth-6, Peg Ppg-18 18 Dimethicone, Sodium Hyaluronate, Hexyldecanol, Caprylic Capric Triglyceride, Disodium Edta, Chlorphenesin, Phenoxyethanol, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/bioderma/hydrabio-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/bioderma/hydrabio-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/bioderma/hydrabio-serum/for/acne-prone-skin