# Anua Nano Retinol 0.3% + Niacin Renewing Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Anua](https://lovi.care/skincare/de/brands/anua)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, with retinol and peptides targeting fine lines and wrinkles, while niacinamide and Centella Asiatica Extract provide soothing support for redness and irritation.
- Numerous botanical extracts contribute antioxidant and anti-inflammatory benefits, enhancing overall skin health and hydration.
- The product is safe for your sensitive skin, as it lacks harsh ingredients and includes soothing components like niacinamide and Centella Asiatica Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/oily-acne-prone-skin): High

## Key ingredients

Retinol, Niacinamide, Centella Asiatica Extract, Sodium Hyaluronate, Ceramide Np

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users find this serum to be an excellent gentle introduction to retinol, effectively smoothing skin texture and refining pores with minimal irritation. While improvements to fine lines and blackheads require consistent use, the formula hydrates and plumps the skin, leaving it glowing and moisturized.

- Liked: Gentle & non-irritating (often mentioned)
- Liked: Improves texture & pores (often mentioned)
- Liked: Brightening effect (sometimes noted)
- Liked: Elegant texture (sometimes noted)
- Liked: Hydrating & plumping (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Initial sensitivity (rarely noted)
- Disliked: Scent preferences (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Anua Nano Retinol 0.3% + Niacin Renewing Serum work for sensitive skin?

This treatment works reasonably well for sensitive skin, though other products fit it better. A treatment for this skin needs calming ingredients like Centella Asiatica Extract and niacinamide, along with soothing hydrators to keep skin comfortable while targeting fine lines.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for sensitive skin?

Niacinamide and Centella Asiatica Extract make this serum a good fit for sensitive skin because they help calm redness and irritation. A treatment of this type needs soothing and barrier-repairing ingredients, such as ceramides and calming plant extracts, along with a gentle formula free from harsh irritants to keep sensitive skin soft and comfortable.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Retinol do for sensitive skin?

Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in your evening routine, applied after your cleanser and soothing toner and before your moisturizer. Treatments with actives are placed at night for simplicity and extra safety around sun exposure.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C, but it is best to apply vitamin C in the morning and this retinol serum at night to lower the chance of irritation on sensitive skin. Using them at different times of day helps your skin tolerate both active ingredients comfortably.

### How often should I use this serum?

This treatment works best in the evening routine, starting just once or twice a week to let sensitive skin adjust. Because it contains retinol, it may cause dryness or irritation initially, so a product of this type needs soothing ingredients like Centella Asiatica extract and niacinamide to keep skin calm and hydrated.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/), [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum may cause temporary purging or initial sensitivity on sensitive skin due to retinol, though it is unlikely to clog pores. A product of this type for sensitive skin needs gentle soothing ingredients like Centella Asiatica Extract and niacinamide, along with barrier-repairing ceramides to keep skin calm and smooth.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

- Amazon.de: €34.00 (https://www.amazon.de/dp/B0CRSZDX59?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycereth-26, Niacinamide, Pyrus Malus Fruit Extract, Glycerin, 1,2-Hexanediol, Caprylic Capric Triglyceride, Chestnut Shell Extract, Glyceryl Citrate Lactate Linoleate Oleate, Diospyros Kaki Leaf Extract, Coptis Japonica Root Extract, Potentilla Anserina Extract, Avena Sativa Kernel Extract Oat Kernel Extract, Cynara Scolymus Leaf Extract, Portulaca Oleracea Extract, Melaleuca Alternifolia Tree Extract, Ficus Carica Fruit Extract, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Artemisia Capillaris Flower Extract, Arnica Montana Flower Extract, Houttuynia Cordata Extract, Melia Azadirachta Leaf Extract, Lavandula Angustifolia Flower Extract Lavender Flower Extract, Chamomilla Recutita Leaf Extract Flower Matricaria Leaf Extract Flower, Borago Officinalis Extract, Centaurea Cyanus Flower Extract, Hydrogenated Lecithin, Camellia Sinensis Leaf Water, Centaurea Cyanus Flower Water, Sodium Hyaluronate, Melaleuca Alternifolia Tree Oil Leaf, Carapa Guianensis Seed Oil, Hippophae Rhamnoides Oil Fruit, Tocopherol, Propanediol, Cetyl Ethylhexanoate, Ammonium Acryloyldimethyltaurate Vp Copolymer, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Polyacrylate Crosspolymer-6, Methylpropanediol, Butylene Glycol, Polysorbate 20, Retinol, Ceramide Np, Pentylene Glycol, Carbomer, Tromethamine, Dipotassium Glycyrrhizate, Ethylhexylglycerin, Adenosine, Disodium Edta, Polyquaternium-51, Beta-Glucan, Squalane, Panthenol, Hydrolyzed Sodium Hyaluronate, Bht, Oleic Acid, Dipropylene Glycol, Bha, Allantoin, Maltodextrin, Saccharide Hydrolysate, Sorbitan Laurate, Glyceryl Stearate, Butyrospermum Parkii Butter Shea Butter, Octyldodecanol, Phytosterols, Madecassoside, Ceramide, Ceramide Ap, Capryloyl Salicylic Acid, Cholesterol, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Ceramide Ns, Ceramide Ng, Caprylyl Glycol, Guaiazulene, Sucrose Distearate, Nonapeptide-1, Acetyl Hexapeptide-8, Copper Tripeptide-1, Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Hydroxypropyl Cyclodextrin, Hexapeptide-9, Ceramide Eop
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/nano-retinol-0-3-niacin-renewing-serum/for/sensitive-skin