# Anua Heartleaf 80 Moisture Soothing Ampoule for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Anua](https://lovi.care/skincare/de/brands/anua)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for sensitive skin.

## Why this fit

- Excellent suitability for your normal skin and addresses your redness and irritation concerns due to Houttuynia Cordata Extract and Allantoin, which provide potent anti-inflammatory and soothing effects.
- The high concentrations of glycerin and hyaluronic acid offer superior hydration, plumping your skin and enhancing its overall comfort.
- The formulation is safe for your sensitive skin, featuring soothing ingredients like Allantoin and Panthenol with no harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-acne-prone-skin): Superior

## Key ingredients

Heartleaf Extract, Hyaluronic Acid, Glycerin, Allantoin, Panthenol

## What the research says

- A hyperoside-enriched fraction of Houttuynia cordata Thunb. inhibited UVB-induced oxidative stress, inflammation, and collagen degradation in human dermal fibroblasts by regulating the MAPK signaling pathway. ([Plants, 2021](https://pubmed.ncbi.nlm.nih.gov/34961096/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Based on a very large amount of data, this ampoule is widely praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and provide deep hydration without clogging pores. While most users achieve a "glass skin" glow and reduced inflammation, a minority experience a tacky finish or find it ineffective for severe breakouts.

- Liked: Soothing redness (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Acne care (sometimes noted)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Small quantity (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Lack of results (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Anua Heartleaf 80 Moisture Soothing Ampoule a great fit for sensitive skin?

This product is a great fit because heartleaf extract and allantoin calm redness and irritation, while high levels of glycerin and hyaluronic acid provide deep hydration to keep your skin comfortable. It is also very safe for sensitive skin because it relies on gentle, soothing ingredients without any harsh substances.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for sensitive skin?

Heartleaf extract and allantoin make this serum a great fit for sensitive skin by helping calm redness and irritation. Panthenol, glycerin, and hyaluronic acid also help by keeping your skin deeply hydrated and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Heartleaf Extract do for sensitive skin?

Heartleaf Extract helps calm sensitive, easily irritated skin by soothing redness and lowering inflammation. It also protects skin cells from everyday damage and oxidative stress.
Sources: [Antioxidants, 2022](https://pubmed.ncbi.nlm.nih.gov/35204104/), [Plants, 2021](https://pubmed.ncbi.nlm.nih.gov/34961096/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after cleansing and toning, as recommended for safety and simplicity. Using it at this step helps soothe sensitive skin and boosts hydration without harsh substances.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the serum first to help calm and hydrate your skin before applying retinol. This soothing approach is unlikely to cause irritation and may help your skin tolerate the retinol better.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this treatment in your evening routine daily, and it is safe for your sensitive skin because it features soothing ingredients with no harsh substances. Daily application helps improve skin moisture and calm irritation.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to cause breakouts for sensitive skin, as its soothing ingredients help calm irritation and it contains no harsh substances. Reviewers rarely report breakouts, making it a safe choice for easily upset skin.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum on the thin skin around your eyes and on your body because its gentle formula is safe for sensitive areas. The soothing ingredients and rich hydration help calm irritation and keep delicate skin comfortable.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/de/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/sensitive-skin) — High fit — €15.99 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/de/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/sensitive-skin) — High fit — €17.99 at Amazon
- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/de/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/sensitive-skin) — High fit — €29.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

- Amazon.de: €17.98 (https://www.amazon.de/dp/B0DKSYXWZJ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €33.90 (https://www.notino.de/anua/heartleaf-80-moisture-ampoule-ampullen-zur-intensiven-erneuerung-der-haut-mit-beruhigender-wirkung/p-16242798/)
Prices checked 16 Oct – 6 Nov 2026.

## Ingredients

Water, Houttuynia Cordata Extract, Glycerin, Butylene Glycol, 1,2-Hexanediol, Hyaluronic Acid, Betaine, Allantoin, Panthenol, Ethylhexylglycerin, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin