# Alastin Skincare HA Immerse Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Alastin Skincare](https://lovi.care/skincare/de/brands/alastin-skincare)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent for your normal skin, this serum effectively targets wrinkles and fine lines with specialized peptides like Octapeptide-45 and Hexapeptide-11 to promote collagen synthesis and elasticity.
- Its highly moisturizing formula, featuring Sodium Hyaluronate and Glycerin, provides excellent hydration and plumping effects, further enhancing skin texture and smoothness.
- The product is safe for your skin, containing soothing ingredients like Tocopherol and Tremella Fuciformis Sporocarp Extract, with no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Tremella Fuciformis Sporocarp Extract Silver Ear Mushroom Extract, Hexapeptide-11, Lactoferrin, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

## What the research says

- Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects. ([Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/))
- The addition of Octapeptide-45 to TriHex technology (TriHex 2.0) significantly increased hyaluronic acid levels and tropoelastin intensity compared to untreated tissue, while also upregulating genes affecting the extracellular matrix and basement membrane. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39660586/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Pre-treatment with Tremella fuciformis polysaccharide reduced oxidative stress and cell apoptosis in hydrogen peroxide-treated human skin fibroblasts via the upregulation of SIRT1 expression. ([Molecular Medicine Reports, 2017](https://pubmed.ncbi.nlm.nih.gov/28627707/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Snow mushroom alcohol-based hand rub gel significantly improved skin moisture better than the placebo through 180 minutes while maintaining comparable antiseptic efficacy in 20 human volunteers. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32531816/))
- Tremella fuciformis extract demonstrates potential cutaneous benefits including skin antiaging, photoprotection, wound healing, and barrier protection based on in vitro and animal models. ([Archives of Dermatological Research, 2023](https://pubmed.ncbi.nlm.nih.gov/36757441/))
- Tremella fuciformis inhibits melanogenesis by decreasing melanin content and tyrosinase expression in B16F10 cells while promoting wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts. ([In Vivo, 2022](https://pubmed.ncbi.nlm.nih.gov/35241526/))
- Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence. ([Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23578831/))
- The combination of sodium ascorbate and lactoferrin demonstrated a significant synergistic effect on tropoelastin stimulation with intact and increased elastin fibers compared to single treatments in an ex vivo human skin model. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38332665/))
- Colostrum-derived exosome-encapsulated lactoferrin promoted cell viability and migration while reducing pro-inflammatory cytokines and phosphorylated JNK in mouse NIH/3T3 and human HS-68 fibroblasts treated with lipopolysaccharide. ([Current Issues in Molecular Biology, 2025](https://pubmed.ncbi.nlm.nih.gov/40729018/))
- Lactoferrin treatment decreased lipid content and attenuated the mRNA expression of lipid metabolism and inflammatory genes in SZ95 human sebocytes, and reduced inflammation, lipid production, and sebaceous gland cell proliferation while increasing apoptosis in a mouse model of acne. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36700382/))

## What reviewers say

This serum is widely celebrated for its transformative hydrating properties, with users reporting significant improvements in skin suppleness, radiance, and the reduction of fine lines. It is particularly favored by those with dry or mature skin for its ability to provide a "plumped" and youthful appearance without causing irritation or leaving a heavy, sticky residue.

- Liked: Instant hydration (mostly mentioned)
- Liked: Layers well (often mentioned)
- Liked: Non-greasy texture (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Smooths fine lines (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Product longevity (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Alastin HA Immerse Serum a great fit for mature skin?

Alastin Skincare HA Immerse Serum is a great fit for mature skin because it targets wrinkles and fine lines using specialized peptides like Octapeptide-45 and Hexapeptide-11 to boost collagen and elasticity. Its moisturizing formula with sodium hyaluronate and glycerin provides deep hydration and plumping effects, while soothing ingredients like tocopherol and silver ear mushroom extract keep your skin calm and smooth with a very low risk of irritation.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains specialized peptides like Hexapeptide-11 and Octapeptide-45 that help smooth out fine lines and wrinkles. It also includes sodium hyaluronate and glycerin to provide deep hydration and leave your skin feeling plump and soft.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Tremella Fuciformis Sporocarp Extract do for mature skin?

Tremella Fuciformis Sporocarp Extract helps mature skin stay soft and smooth by holding onto moisture while also protecting against everyday damage that can make skin look tired. It supports the skin barrier and may help calm irritation, keeping your complexion looking fresh and healthy. Products for mature skin benefit most when they pair this ingredient with deep hydrators and antioxidants.
Sources: [Molecular Medicine Reports, 2017](https://pubmed.ncbi.nlm.nih.gov/28627707/), [Photochemical & Photobiological Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37458972/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe around sun exposure. Using targeted treatments at night helps support collagen synthesis and elasticity for mature skin.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39660586/)

### Can I use this serum with retinol, and in what order?

You can use this serum alongside retinol, applying the serum first to hydrate and smooth your skin before your retinol product. This helps keep mature skin comfortable and is unlikely to cause irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This serum fits well into your evening routine as a treatment step, used once a day for simplicity and extra safety around sun exposure. Applying it consistently helps improve hydration, firmness, and fine lines over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is a great fit for mature skin and is unlikely to clog pores, cause breakouts, or lead to purging. Its soothing ingredients and gentle moisturizing formula make it well-suited for regular use without causing irritation.

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment around the eyes or on the body, though the skin around the eyes and on certain body areas is very thin and may react differently than facial skin. Its hydrating formula helps keep thin areas smooth and plump, while peptides like Hexapeptide-11 improve elasticity with a very low risk of irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — €22.75 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/de/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €17.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/de/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €15.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/de/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €18.00 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Polyacrylate-13, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Octapeptide-45, Hexapeptide-11, Tremella Fuciformis Sporocarp Extract Silver Ear Mushroom Extract, Lactoferrin, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xylitol, Propanediol, Anhydroxylitol, Xylitylglucoside, Phosphatidylserine, Glucose, Hydroxymethoxyphenyl Decanone, Tocopherol, Ascorbyl Palmitate, Dimethicone, Caprylyl Methicone, Caprylic Capric Triglyceride, Polyisobutene, Caprylyl Glycol, Disodium Edta, Betaine, Polysorbate 20, Ethylhexylglycerin, Caprylhydroxamic Acid, Sorbitan Isostearate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Lecithin, Pentylene Glycol, Magnesium Chloride, Phenoxyethanol, Potassium Sorbate, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/alastin-skincare/ha-immerse-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/alastin-skincare/ha-immerse-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/alastin-skincare/ha-immerse-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/alastin-skincare/ha-immerse-serum/for/mature-skin (this page)
- France: https://lovi.care/skincare/fr/p/alastin-skincare/ha-immerse-serum/for/mature-skin
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- Netherlands: https://lovi.care/skincare/nl/p/alastin-skincare/ha-immerse-serum/for/mature-skin
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