# Protease and palmitoyl pentapeptide-4

Page: https://lovi.care/skincare/de/ingredients/protease-and-palmitoyl-pentapeptide-4

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Keep them apart

Use them at different times of day, applying the [protease](https://lovi.care/skincare/de/ingredients/protease) first and the peptide later, because they cancel each other out. Protease breaks down the peptide, making it completely useless on your skin. You can space them out by using one in the morning and the other at night.

- [All about protease](https://lovi.care/skincare/de/ingredients/protease)
- [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/palmitoyl-pentapeptide-4)

### [Protease](https://lovi.care/skincare/de/ingredients/protease) products

- [COSRX Centella Cleansing Powder](https://lovi.care/skincare/de/p/cosrx/centella-cleansing-powder/for/combination-skin) — Superior fit
- [FANCL Deep Clear Washing Powder](https://lovi.care/skincare/de/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit — [€19.99 at Amazon](https://www.amazon.de/dp/B01KTJXVI4?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/palmitoyl-pentapeptide-4) products

- [Olay Eye Lifting Serum](https://lovi.care/skincare/de/p/olay/eye-lifting-serum/for/dry-skin) — High fit — [€28.99 at Amazon](https://www.amazon.de/dp/B00OUV2WYW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use protease and palmitoyl pentapeptide-4 together?

Keep [protease](https://lovi.care/skincare/de/ingredients/protease) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/palmitoyl-pentapeptide-4) apart because proteolytic enzymes may degrade peptide bonds and render the active peptide inactive. Avoid combining them in the same routine.

### Which goes first, protease or palmitoyl pentapeptide-4?

Keep protease and palmitoyl pentapeptide-4 apart because enzymes can degrade peptide bonds and render the peptides inactive. You should avoid combining proteolytic enzymes with peptides in the same routine.

### Are protease and palmitoyl pentapeptide-4 good for sensitive skin?

No, you should keep protease and palmitoyl pentapeptide-4 apart because enzymes can degrade peptide bonds and render the peptides inactive. It is best to avoid combining enzymatic ingredients with peptide-containing products in the same routine.

## Research on protease and palmitoyl pentapeptide-4

- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913](https://pubmed.ncbi.nlm.nih.gov/29146927/) Protease · Scientific Reports, 2017
- [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026

## Other combinations

- Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/adapalene-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/retinal-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/tretinoin-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4)
- Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/liposome-and-palmitoyl-pentapeptide-4)
- Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/microcapsule-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4)
- Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/betaine-and-palmitoyl-pentapeptide-4)
- Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/glycerin-and-palmitoyl-pentapeptide-4)
- Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/panthenol-and-palmitoyl-pentapeptide-4)
- Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4)
- Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/arginine-and-palmitoyl-pentapeptide-4)
- Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/gaba-and-palmitoyl-pentapeptide-4)
- Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4)
- Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/taurine-and-palmitoyl-pentapeptide-4)
- Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/de/ingredients/palmitoyl-pentapeptide-4-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/citric-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4)
- Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/green-tea-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/cholesterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/phytosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/squalene-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/bleach-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/copper-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/magnesium-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/zinc-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-protease)
- Keep them apart: [Collagen peptide and protease](https://lovi.care/skincare/de/ingredients/collagen-peptide-and-protease)
- Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/de/ingredients/copper-peptide-and-protease)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/de/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/de/ingredients/protease-and-palmitoyl-tripeptide-1)
- Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/de/ingredients/peptide-rich-plasma-and-protease)
- Keep them apart: [Protease and triple peptide blend](https://lovi.care/skincare/de/ingredients/protease-and-triple-peptide-blend)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/protease-and-palmitoyl-pentapeptide-4
- United Kingdom: https://lovi.care/skincare/uk/ingredients/protease-and-palmitoyl-pentapeptide-4
- Ireland: https://lovi.care/skincare/ie/ingredients/protease-and-palmitoyl-pentapeptide-4
- Germany: https://lovi.care/skincare/de/ingredients/protease-and-palmitoyl-pentapeptide-4 (this page)
- France: https://lovi.care/skincare/fr/ingredients/protease-and-palmitoyl-pentapeptide-4
- Italy: https://lovi.care/skincare/it/ingredients/protease-and-palmitoyl-pentapeptide-4
- Netherlands: https://lovi.care/skincare/nl/ingredients/protease-and-palmitoyl-pentapeptide-4
- Spain: https://lovi.care/skincare/es/ingredients/protease-and-palmitoyl-pentapeptide-4
- Canada: https://lovi.care/skincare/ca/ingredients/protease-and-palmitoyl-pentapeptide-4
- Australia: https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-pentapeptide-4
- Singapore: https://lovi.care/skincare/sg/ingredients/protease-and-palmitoyl-pentapeptide-4
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/protease-and-palmitoyl-pentapeptide-4
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/protease-and-palmitoyl-pentapeptide-4