# Lactic acid and hexapeptide-9 Page: https://lovi.care/skincare/de/ingredients/lactic-acid-and-hexapeptide-9 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany. Keep them apart Use them at different times of day by applying [lactic acid](https://lovi.care/skincare/de/ingredients/lactic-acid) in the morning and [hexapeptide-9](https://lovi.care/skincare/de/ingredients/hexapeptide-9) at night, because acid ruins the peptide. The acid is too strong for the peptide and breaks it down, so your skin misses out on the anti-aging benefits. You can fix this by using them in separate routines or waiting longer between steps. - [All about lactic acid](https://lovi.care/skincare/de/ingredients/lactic-acid) - [All about hexapeptide-9](https://lovi.care/skincare/de/ingredients/hexapeptide-9) ### [Lactic acid](https://lovi.care/skincare/de/ingredients/lactic-acid) products - [Medicube Zero Pore Pad](https://lovi.care/skincare/de/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.de/dp/B09V7Z4TJG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [First Aid Beauty KP Bump Eraser Body Scrub](https://lovi.care/skincare/de/p/first-aid-beauty/kp-bump-eraser-body-scrub/for/dark-spots) — Average fit — [€25.02 at Amazon](https://www.amazon.de/dp/B08GNS58PQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [EltaMD UV Clear Broad-Spectrum SPF 46](https://lovi.care/skincare/de/p/eltamd/uv-clear-broad-spectrum-spf-46/for/oily-acne-prone-skin) — Superior fit — [€72.80 at Amazon](https://www.amazon.de/dp/B00ZPWR0N8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [First Aid Beauty Facial Radiance Pads](https://lovi.care/skincare/de/p/first-aid-beauty/facial-radiance-pads/for/sensitive-skin) — Superior fit — [€17.25 at Lookfantastic](https://www.lookfantastic.de/p/first-aid-beauty-brighten-glow-pads-28-ct./17716506/) - [CeraVe SA Lotion for Rough & Bumpy Skin](https://lovi.care/skincare/de/p/cerave/sa-lotion-for-rough-and-bumpy-skin/for/oily-skin) — Average fit — [€14.75 at Amazon](https://www.amazon.de/dp/B07W8H8MBX?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [CeraVe Renewing SA Cream](https://lovi.care/skincare/de/p/cerave/renewing-sa-cream/for/oily-acne-prone-skin) — High fit - [The Ordinary Alpha Arbutin 2% + HA](https://lovi.care/skincare/de/p/the-ordinary/alpha-arbutin-2-ha/for/dark-spots) — Superior fit — [€10.16 at Amazon](https://www.amazon.de/dp/B06XCZFCFZ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [The Ordinary Retinal 0.2% Emulsion](https://lovi.care/skincare/de/p/the-ordinary/retinal-0-2-emulsion/for/oily-acne-prone-skin) — High fit — [€17.50 at Amazon](https://www.amazon.de/dp/B0CZ5VG3L1?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Kate Somerville ExfoliKate Intensive Exfoliating Treatment](https://lovi.care/skincare/de/p/kate-somerville/exfolikate-intensive-exfoliating-treatment/for/mature-skin) — Superior fit — [€282.20 at Amazon](https://www.amazon.de/dp/B002M3NV2C?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Dr. Dennis Gross Alpha Beta Universal Daily Peel](https://lovi.care/skincare/de/p/dr-dennis-gross/alpha-beta-universal-daily-peel/for/acne-prone-skin) — Superior fit — [€168.25 at Amazon](https://www.amazon.de/dp/B009QZ595Q?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [The Ordinary Lactic Acid 5% + HA](https://lovi.care/skincare/de/p/the-ordinary/lactic-acid-5-ha/for/dry-skin) — Superior fit - [Good Molecules Overnight Exfoliating Treatment](https://lovi.care/skincare/de/p/good-molecules/overnight-exfoliating-treatment/for/oily-skin) — Superior fit — [€20.99 at Amazon](https://www.amazon.de/dp/B08TMDRF1L?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ### [Hexapeptide-9](https://lovi.care/skincare/de/ingredients/hexapeptide-9) products - [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/de/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.de/dp/B00175YVOS?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/de/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit - [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/de/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€12.90 at Amazon](https://www.amazon.de/dp/B095YHYF33?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use lactic acid and hexapeptide-9 together? Keep [lactic acid](https://lovi.care/skincare/de/ingredients/lactic-acid) and [hexapeptide-9](https://lovi.care/skincare/de/ingredients/hexapeptide-9) apart in your routine because the low pH of the acid may destabilize the peptide bonds and reduce its effectiveness. Instead, use them in separate steps or routines, such as applying one in the morning and the other at night. ### Which goes first, lactic acid or hexapeptide-9? Keep lactic acid and hexapeptide-9 separate by using them in different routines, such as applying one in the morning and the other at night, because the low pH of lactic acid can destabilize hexapeptide-9 and reduce its effectiveness. ### Are lactic acid and hexapeptide-9 good for sensitive skin? Lactic acid and hexapeptide-9 should be kept apart to protect sensitive skin. The low pH of lactic acid destabilizes peptide bonds and may reduce the bioactivity of hexapeptide-9 when used in the same routine. ## Research on lactic acid and hexapeptide-9 - [Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts](https://pubmed.ncbi.nlm.nih.gov/39102921/) Lactic acid · International Journal of Biological Macromolecules, 2024 - [Poly-L-Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF-β/Smad pathway](https://pubmed.ncbi.nlm.nih.gov/36575891/) Lactic acid · Journal of Cosmetic Dermatology, 2023 - [Do urea/ammonium lactate combinations achieve better skin protection and hydration than either component alone?](https://pubmed.ncbi.nlm.nih.gov/11803256/) Lactic acid · Skin Pharmacology and Applied Skin Physiology, 2002 - [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Keep them apart: [Benzoyl peroxide and lactic acid](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-lactic-acid) - Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/de/ingredients/retinol-and-lactic-acid) - Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/de/ingredients/niacinamide-and-lactic-acid) - Work well together: [Lactic acid and sodium lactate](https://lovi.care/skincare/de/ingredients/lactic-acid-and-sodium-lactate) - Work well together: [Lactic acid and tromethamine](https://lovi.care/skincare/de/ingredients/lactic-acid-and-tromethamine) - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/de/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/granactive-retinoid-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/de/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/de/ingredients/pro-retinol-and-hexapeptide-9) - Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/de/ingredients/retinal-and-hexapeptide-9) - Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/de/ingredients/retinoid-blend-and-hexapeptide-9) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/de/ingredients/retinol-and-hexapeptide-9) - Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/de/ingredients/tretinoin-and-hexapeptide-9) - Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/de/ingredients/vitamin-a-and-hexapeptide-9) - Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/de/ingredients/liposome-and-hexapeptide-9) - Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/de/ingredients/microcapsule-and-hexapeptide-9) - Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/de/ingredients/vitamin-c-and-hexapeptide-9) - Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/de/ingredients/betaine-and-hexapeptide-9) - Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/de/ingredients/glycerin-and-hexapeptide-9) - Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/hyaluronic-acid-and-hexapeptide-9) - Work well together: [Lactic acid and betaine](https://lovi.care/skincare/de/ingredients/lactic-acid-and-betaine) - Work well together: [Glycerin and lactic acid](https://lovi.care/skincare/de/ingredients/glycerin-and-lactic-acid) - Depends on the strength: [Lactic acid and hyaluronic acid](https://lovi.care/skincare/de/ingredients/lactic-acid-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/de/ingredients/niacinamide-and-hexapeptide-9) - Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/de/ingredients/panthenol-and-hexapeptide-9) - Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/de/ingredients/bakuchiol-and-hexapeptide-9) - Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/de/ingredients/arginine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-gaba) - Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/de/ingredients/silk-amino-acids-and-hexapeptide-9) - Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/de/ingredients/taurine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/de/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9) - Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/citric-acid-and-hexapeptide-9) - Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hexapeptide-9) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Bio-placenta peptides and lactic acid](https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-lactic-acid) - Keep them apart: [Carnosine and lactic acid](https://lovi.care/skincare/de/ingredients/carnosine-and-lactic-acid) - Keep them apart: [Lactic acid and collagen peptide](https://lovi.care/skincare/de/ingredients/lactic-acid-and-collagen-peptide) - Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/de/ingredients/lactic-acid-and-copper-peptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/de/ingredients/lactic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Lactic acid and peptide-rich plasma](https://lovi.care/skincare/de/ingredients/lactic-acid-and-peptide-rich-plasma) - Keep them apart: [Lactic acid and triple peptide blend](https://lovi.care/skincare/de/ingredients/lactic-acid-and-triple-peptide-blend) - Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/mandelic-acid-and-hexapeptide-9) - Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/de/ingredients/coenzyme-q10-and-hexapeptide-9) - Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/de/ingredients/green-tea-and-hexapeptide-9) - Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/de/ingredients/vitamin-e-and-hexapeptide-9) - Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/de/ingredients/adapalene-and-lactic-acid) - Keep them apart: [Lactic acid and granactive retinoid](https://lovi.care/skincare/de/ingredients/lactic-acid-and-granactive-retinoid) - Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/de/ingredients/lactic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and lactic acid](https://lovi.care/skincare/de/ingredients/pro-retinol-and-lactic-acid) - Keep them apart: [Retinal and lactic acid](https://lovi.care/skincare/de/ingredients/retinal-and-lactic-acid) - Keep them apart: [Lactic acid and retinoid blend](https://lovi.care/skincare/de/ingredients/lactic-acid-and-retinoid-blend) - Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/de/ingredients/tretinoin-and-lactic-acid) - Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/de/ingredients/ceramide-building-complex-and-hexapeptide-9) - Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/de/ingredients/cholesterol-and-hexapeptide-9) - Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-hexapeptide-9) - Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/de/ingredients/phytosterol-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-squalene) - Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-tri-ceramide-complex) - Work well together: [Lactic acid and gluconolactone](https://lovi.care/skincare/de/ingredients/lactic-acid-and-gluconolactone) - Work well together: [Lactic acid and lactobionic acid](https://lovi.care/skincare/de/ingredients/lactic-acid-and-lactobionic-acid) - Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-hexapeptide-9) - Work well together: [Lactic acid and cholesterol](https://lovi.care/skincare/de/ingredients/lactic-acid-and-cholesterol) - Work well together: [Lactic acid and lauric acid](https://lovi.care/skincare/de/ingredients/lactic-acid-and-lauric-acid) - Work well together: [Linoleic acid and lactic acid](https://lovi.care/skincare/de/ingredients/linoleic-acid-and-lactic-acid) - Keep them apart: [Lactic acid and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/lactic-acid-and-tri-ceramide-complex) - Work well together: [Arginine and lactic acid](https://lovi.care/skincare/de/ingredients/arginine-and-lactic-acid) - Work well together: [Lactic acid and GABA](https://lovi.care/skincare/de/ingredients/lactic-acid-and-gaba) - Work well together: [Silk amino acids and lactic acid](https://lovi.care/skincare/de/ingredients/silk-amino-acids-and-lactic-acid) - Work well together: [Lactic acid and taurine](https://lovi.care/skincare/de/ingredients/lactic-acid-and-taurine) - Work well together: [Lactic acid and theanine](https://lovi.care/skincare/de/ingredients/lactic-acid-and-theanine) - Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-baking-soda) - Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/de/ingredients/bleach-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-behenyl-alcohol) - Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/de/ingredients/polyvinyl-alcohol-and-hexapeptide-9) - Work well together: [Ferulic acid and lactic acid](https://lovi.care/skincare/de/ingredients/ferulic-acid-and-lactic-acid) - Work well together: [Vitamin E and lactic acid](https://lovi.care/skincare/de/ingredients/vitamin-e-and-lactic-acid) - Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/de/ingredients/copper-and-hexapeptide-9) - Keep them apart: [Azelaic acid and lactic acid](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-lactic-acid) - Keep them apart: [Salicylic acid and lactic acid](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-lactic-acid) - Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-hexapeptide-9) - Work well together: [Allantoin and lactic acid](https://lovi.care/skincare/de/ingredients/allantoin-and-lactic-acid) - Work well together: [Lactic acid and bisabolol](https://lovi.care/skincare/de/ingredients/lactic-acid-and-bisabolol) - Work well together: [Panthenol and lactic acid](https://lovi.care/skincare/de/ingredients/panthenol-and-lactic-acid) - Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/de/ingredients/magnesium-and-hexapeptide-9) - Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/de/ingredients/zinc-and-hexapeptide-9) - Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/de/ingredients/zinc-sulfate-and-hexapeptide-9) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/de/ingredients/superoxide-dismutase-and-hexapeptide-9) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/lactic-acid-and-hexapeptide-9 - United Kingdom: https://lovi.care/skincare/uk/ingredients/lactic-acid-and-hexapeptide-9 - Ireland: https://lovi.care/skincare/ie/ingredients/lactic-acid-and-hexapeptide-9 - Germany: https://lovi.care/skincare/de/ingredients/lactic-acid-and-hexapeptide-9 (this page) - France: https://lovi.care/skincare/fr/ingredients/lactic-acid-and-hexapeptide-9 - Italy: https://lovi.care/skincare/it/ingredients/lactic-acid-and-hexapeptide-9 - Netherlands: https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9 - Spain: https://lovi.care/skincare/es/ingredients/lactic-acid-and-hexapeptide-9 - Canada: https://lovi.care/skincare/ca/ingredients/lactic-acid-and-hexapeptide-9 - Australia: https://lovi.care/skincare/au/ingredients/lactic-acid-and-hexapeptide-9 - Singapore: https://lovi.care/skincare/sg/ingredients/lactic-acid-and-hexapeptide-9 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/lactic-acid-and-hexapeptide-9 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/lactic-acid-and-hexapeptide-9