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Hydroxypinacolone retinoate

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Hydroxypinacolone retinoate

Hydroxypinacolone retinoate visibly smooths fine lines, refines skin texture, improves hydration and elasticity, evens out dark spots, and clears acne blemishes. This active ingredient suits dry skin and oily skin best, and it comes in serums. You can easily fit it into a daily routine by keeping it apart from glycolic acid, benzoyl peroxide, and vitamin C.

Journal of Clinical Medicine, 2023Journal of Cosmetic Dermatology, 2023

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Other hydroxypinacolone retinoate products

What reviewers say about popular hydroxypinacolone retinoate products

The highlight reviewers mention most for each popular hydroxypinacolone retinoate product on Lovi.

Hydroxypinacolone retinoate for dry skin

Hydroxypinacolone retinoate for oily skin

Hydroxypinacolone retinoate for combination skin

Hydroxypinacolone retinoate for sensitive skin

Hydroxypinacolone retinoate for acne-prone skin

Hydroxypinacolone retinoate for mature skin

What to combine hydroxypinacolone retinoate with

IngredientTogetherHow to use them
Niacinamide Depends Use them at different times of day, applying niacinamide in the morning and the retinoid at night, because their combined strength can cause irritation. Hydroxypinacolone retinoate and niacinamide
Glycolic acid Keep apart Use them on alternate nights because they are too strong to put on your face at the same time. Hydroxypinacolone retinoate and glycolic acid
Benzoyl peroxide Keep apart Use them at different times of day, applying benzoyl peroxide in the morning and hydroxypinacolone retinoate at night, because they cancel each other out. Hydroxypinacolone retinoate and benzoyl peroxide
Vitamin C Keep apart Use them at different times of day, applying vitamin C in the morning and hydroxypinacolone retinoate at night, because combining them causes skin irritation. Hydroxypinacolone retinoate and vitamin C
AHA blend glycolic and citric acids Keep apart Use them on alternate nights because combining them can cause severe skin irritation. Hydroxypinacolone retinoate and aha blend glycolic and citric acids
Salicylic acid Keep apart Use them on alternate nights because they can cause too much dryness when layered together. Hydroxypinacolone retinoate and salicylic acid
Bio-placenta peptides Keep apart Use them at different times of day by applying bio-placenta peptides in the morning and hydroxypinacolone retinoate at night, to avoid extra skin irritation. Hydroxypinacolone retinoate and bio-placenta peptides
Hexapeptide Keep apart Use them at different times of day by applying your peptide product in the morning and your hydroxypinacolone retinoate at night. Hydroxypinacolone retinoate and hexapeptide
Lactic acid Keep apart Use them on alternate nights because combining them can cause skin irritation. Hydroxypinacolone retinoate and lactic acid
Acetyl hexapeptide-3 Keep apart Use them at different times of day by applying the peptide product in the morning and the retinoid at night to avoid skin irritation. Hydroxypinacolone retinoate and acetyl hexapeptide-3
Mandelic acid Keep apart Use them on alternate nights, with mandelic acid on one evening and hydroxypinacolone retinoate on the next, because combining them causes irritation. Hydroxypinacolone retinoate and mandelic acid
Collagen peptide Keep apart Use them at different times of day by applying the peptide product in the morning and the retinoid at night to avoid skin irritation. Hydroxypinacolone retinoate and collagen peptide
Copper peptide Keep apart Use them at different times of day with copper peptide in the morning and hydroxypinacolone retinoate at night, because combining them can cause irritation. Hydroxypinacolone retinoate and copper peptide
Citric acid Keep apart Use them on alternate nights because combining them can cause skin irritation. Hydroxypinacolone retinoate and citric acid
Hexapeptide-9 Keep apart Use them at different times of day by applying hexapeptide-9 in the morning and hydroxypinacolone retinoate at night, to avoid extra skin irritation. Hydroxypinacolone retinoate and hexapeptide-9
Peptide-rich plasma Keep apart Use them at different times of day, applying the peptide serum in the morning and the retinoid at night, to avoid extra skin irritation. Hydroxypinacolone retinoate and peptide-rich plasma
Triple peptide blend Keep apart Use them at different times of day, applying the peptide blend in the morning and the retinoid at night, to avoid extra skin irritation. Hydroxypinacolone retinoate and triple peptide blend
Palmitoyl pentapeptide-4 Keep apart Use them at different times of day by applying the peptide serum in the morning and the retinoid at night to prevent irritation. Hydroxypinacolone retinoate and palmitoyl pentapeptide-4
Palmitoyl tripeptide-1 Keep apart Use them at different times of day by applying the peptide in the morning and the retinoid at night, because combining them can cause irritation. Hydroxypinacolone retinoate and palmitoyl tripeptide-1

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

What does hydroxypinacolone retinoate do for the skin?

Hydroxypinacolone retinoate helps improve skin wrinkles, smoothness, elasticity, and hydration while reducing signs of photoaging and blemishes. It may also enhance skin barrier function and reduce microscopic acne features.

Journal of Clinical Medicine, 2023Journal of Cosmetic Dermatology, 2023

How do you use hydroxypinacolone retinoate?

You use hydroxypinacolone retinoate at night, and you can pair it with retinyl propionate for anti-aging benefits.

Journal of Cosmetic Dermatology, 2023

Should you use hydroxypinacolone retinoate in the morning or at night?

You should use hydroxypinacolone retinoate at night. It is typically applied in the evening because certain daytime partner ingredients and sunlight exposure can interact with retinoids.

Can you use hydroxypinacolone retinoate every day?

Yes, you can use hydroxypinacolone retinoate every day, as studies show it improves skin wrinkles, smoothness, and elasticity over weeks of regular use without causing adverse reactions.

Journal of Cosmetic Dermatology, 2023

Does hydroxypinacolone retinoate cause purging or irritation?

Hydroxypinacolone retinoate helps improve skin aging and may cause skin irritation when combined with certain active ingredients. Using it at night while applying incompatible ingredients in the morning helps avoid this issue.

Journal of Cosmetic Dermatology, 2023

Which skin types is hydroxypinacolone retinoate best for?

Hydroxypinacolone retinoate is best for oily, combination, sensitive, and acne-prone skin types, with Lovi giving the highest fit rating to The Ordinary Granactive Retinoid 2% Emulsion for these skin concerns. Sunday Riley A+ High-Dose Retinoid Serum also achieves a high fit for oily, acne-prone, and dark spot-prone skin.

Can you use hydroxypinacolone retinoate with glycolic acid?

No, you should keep them apart and use them on alternate nights because they are too strong to put on your face at the same time.

Research on hydroxypinacolone retinoate

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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