# Hexapeptide and squalene Page: https://lovi.care/skincare/de/ingredients/hexapeptide-and-squalene The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany. Work well together Use them together by applying the peptide [serum](https://lovi.care/skincare/de/ingredients/serum) first, because the [squalene oil](https://lovi.care/skincare/de/ingredients/squalene) helps it sink in and locks in moisture. The squalene helps the peptide work better and makes your skin feel softer and stronger. If your skin feels too rich, you can switch to a lighter moisturizer or use them less often. - [All about hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) - [All about squalene](https://lovi.care/skincare/de/ingredients/squalene) ### [Hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/de/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€150.00 at Amazon](https://www.amazon.de/dp/B0FPFJ16KT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ### [Squalene](https://lovi.care/skincare/de/ingredients/squalene) products - [Clinique Even Better Clinical Dark Spot Corrector](https://lovi.care/skincare/de/p/clinique/even-better-clinical-dark-spot-corrector/for/oily-skin) — High fit - [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit — [€83.90 at Amazon](https://www.amazon.de/dp/B01N5HLNB8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Perricone MD Vitamin C Ester CCC+ Ferulic Brightening Under-Eye Cream](https://lovi.care/skincare/de/p/perricone-md/vitamin-c-ester-ccc-ferulic-brightening-under-eye-cream/for/dark-spots) — High fit — [€64.80 at Amazon](https://www.amazon.de/dp/B0CP6FJ2P1?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Aestura A-Cica 365 Blemish Calming Serum](https://lovi.care/skincare/de/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin) — High fit ## Questions and answers ### Can you use hexapeptide and squalene together? Yes, [hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) and [squalene](https://lovi.care/skincare/de/ingredients/squalene) work well together because squalene acts as a lipid component that helps improve peptide absorption and reinforce skin structure. Lovi rates this combination as Superior for dry, mature, and barrier-impaired skin. [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/) [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) ### Which goes first, hexapeptide or squalene? Hexapeptide and squalene work well together because squalene is a lipid that improves peptide absorption and reinforces skin structure. You can use them together to enhance barrier repair, with the lighter water-based hexapeptide [serum](https://lovi.care/skincare/de/ingredients/serum) generally applied before the richer squalene oil. ### Are hexapeptide and squalene good for sensitive skin? Hexapeptide and squalene work well together because squalene is a lipid that improves peptide absorption and reinforces skin structure, making the combination beneficial for dry, mature, or barrier-impaired skin. ## Research on hexapeptide and squalene - [Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology](https://pubmed.ncbi.nlm.nih.gov/19169201/) Squalene · Molecules, 2009 - [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalene · Scientific Reports, 2020 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 ## Other combinations - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/de/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/de/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/de/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/de/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/de/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/de/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/de/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/de/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/de/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/de/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/de/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/de/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/de/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/de/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/de/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/de/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/de/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/de/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/de/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/de/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-squalene) - Work well together: [Bio-placenta peptides and squalene](https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-squalene) - Work well together: [Collagen peptide and squalene](https://lovi.care/skincare/de/ingredients/collagen-peptide-and-squalene) - Work well together: [Copper peptide and squalene](https://lovi.care/skincare/de/ingredients/copper-peptide-and-squalene) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/de/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/hexapeptide-and-tri-ceramide-complex) - Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-squalene) - Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/squalene-and-palmitoyl-pentapeptide-4) - Work well together: [Squalene and palmitoyl tripeptide-1](https://lovi.care/skincare/de/ingredients/squalene-and-palmitoyl-tripeptide-1) - Work well together: [Peptide-rich plasma and squalene](https://lovi.care/skincare/de/ingredients/peptide-rich-plasma-and-squalene) - Work well together: [Squalene and triple peptide blend](https://lovi.care/skincare/de/ingredients/squalene-and-triple-peptide-blend) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/de/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/de/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/de/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/de/ingredients/hexapeptide-and-copper) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/de/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/de/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/de/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-squalene - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-squalene - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-squalene - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-squalene (this page) - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-squalene - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-squalene - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-squalene - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-squalene - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-squalene - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-squalene - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-squalene - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-squalene - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-squalene