# Hexapeptide and phytosphingosine Page: https://lovi.care/skincare/de/ingredients/hexapeptide-and-phytosphingosine The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany. Work well together Use them together by applying the [hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) first and the [phytosphingosine](https://lovi.care/skincare/de/ingredients/phytosphingosine) right after, because lipids help the peptide absorb better. Phytosphingosine reinforces your skin barrier while the hexapeptide smooths out fine lines, making them work wonderfully as a team. You do not need to change anything, but you can wait a minute between steps if your skin is sensitive. - [All about hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) - [All about phytosphingosine](https://lovi.care/skincare/de/ingredients/phytosphingosine) ### [Hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/de/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€150.00 at Amazon](https://www.amazon.de/dp/B0FPFJ16KT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ### [Phytosphingosine](https://lovi.care/skincare/de/ingredients/phytosphingosine) products - [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/de/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [€8.85 at Amazon](https://www.amazon.de/dp/B07C5R51Q9?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/de/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [€38.99 at Amazon](https://www.amazon.de/dp/B0D9C55KBF?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Aestura Atobarrier 365 Cream](https://lovi.care/skincare/de/p/aestura/atobarrier-365-cream/for/dry-skin) — High fit — [€31.00 at Amazon](https://www.amazon.de/dp/B09YDCCJBJ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Cetaphil Ceramide Serum](https://lovi.care/skincare/de/p/cetaphil/ceramide-serum/for/acne-prone-skin) — Superior fit — [€39.77 at Amazon](https://www.amazon.de/dp/B0CZD72G5W?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Bioderma Atoderm Intensive Eye](https://lovi.care/skincare/de/p/bioderma/atoderm-intensive-eye/for/acne-prone-skin) — High fit — [€20.73 at Amazon](https://www.amazon.de/dp/B08562FW67?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Obagi Rebalance Skin Barrier Recovery Cream](https://lovi.care/skincare/de/p/obagi/rebalance-skin-barrier-recovery-cream/for/dry-sensitive-skin) — High fit - [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit — [€83.90 at Amazon](https://www.amazon.de/dp/B01N5HLNB8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use hexapeptide and phytosphingosine together? Yes, [hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) and [phytosphingosine](https://lovi.care/skincare/de/ingredients/phytosphingosine) work well together to enhance skin repair and barrier support, as lipids help improve peptide absorption and reinforce skin structure. ### Which goes first, hexapeptide or phytosphingosine? Hexapeptide and phytosphingosine work well together, and you can combine them to enhance skin barrier repair and support. Lipids like phytosphingosine help improve peptide absorption while reinforcing the skin structure. [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/) ### Are hexapeptide and phytosphingosine good for sensitive skin? Hexapeptide and phytosphingosine work well together to enhance skin barrier support and repair. Combining them helps improve skin structure, making them beneficial for dry, mature, and barrier-impaired skin. [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/) [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/) ## Research on hexapeptide and phytosphingosine - [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 - [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002 - [Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin](https://pubmed.ncbi.nlm.nih.gov/18489360/) Phytosphingosine · International Journal of Cosmetic Science, 2007 ## Other combinations - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/de/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/de/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/de/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/de/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/de/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/de/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/de/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/de/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/de/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/de/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/de/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/de/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/de/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/de/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/de/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/de/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/de/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/de/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/de/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/de/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) - Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-phytosphingosine) - Work well together: [Collagen peptide and phytosphingosine](https://lovi.care/skincare/de/ingredients/collagen-peptide-and-phytosphingosine) - Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-copper-peptide) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/de/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/de/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/hexapeptide-and-tri-ceramide-complex) - Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-hexapeptide-9) - Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1) - Work well together: [Phytosphingosine and peptide-rich plasma](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-peptide-rich-plasma) - Work well together: [Phytosphingosine and triple peptide blend](https://lovi.care/skincare/de/ingredients/phytosphingosine-and-triple-peptide-blend) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/de/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/de/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/de/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/de/ingredients/hexapeptide-and-copper) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/de/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/de/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/de/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-phytosphingosine - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-phytosphingosine - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-phytosphingosine (this page) - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-phytosphingosine - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosphingosine - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-phytosphingosine - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-phytosphingosine - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosphingosine - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-phytosphingosine - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-phytosphingosine - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-phytosphingosine - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-phytosphingosine