# Glycolic acid and hexapeptide

Page: https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hexapeptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Keep them apart

Use them at different times of day, applying [glycolic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid) in the morning and [hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) at night, because acid ruins peptide strength. Glycolic acid breaks down hexapeptide bonds so the peptide stops working effectively on your skin. You can use an acid with a gentler strength or separate them into different routines.

- [All about glycolic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid)
- [All about hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide)

### [Glycolic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid) products

- [The Ordinary Glycolic Acid 7% Toning Solution](https://lovi.care/skincare/de/p/the-ordinary/glycolic-acid-7-toning-solution/for/combination-skin) — Superior fit — [€13.90 at Amazon](https://www.amazon.de/dp/B071914GGL?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [RoC Retinol Correxion Deep Wrinkle Night Cream](https://lovi.care/skincare/de/p/roc/retinol-correxion-deep-wrinkle-night-cream/for/dark-spots) — High fit — [€33.34 at Amazon](https://www.amazon.de/dp/B0GXBBV93V?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [First Aid Beauty KP Bump Eraser Body Scrub](https://lovi.care/skincare/de/p/first-aid-beauty/kp-bump-eraser-body-scrub/for/dark-spots) — Average fit — [€25.02 at Amazon](https://www.amazon.de/dp/B08GNS58PQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [First Aid Beauty Facial Radiance Pads](https://lovi.care/skincare/de/p/first-aid-beauty/facial-radiance-pads/for/sensitive-skin) — Superior fit — [€17.25 at Lookfantastic](https://www.lookfantastic.de/p/first-aid-beauty-brighten-glow-pads-28-ct./17716506/)
- [Murad Rapid Dark Spot Correcting Serum](https://lovi.care/skincare/de/p/murad/rapid-dark-spot-correcting-serum/for/acne-prone-skin) — High fit
- [Skinbetter Science AlphaRet Overnight Cream](https://lovi.care/skincare/de/p/skinbetter-science/alpharet-overnight-cream/for/dry-sensitive-skin) — High fit — [€12.99 at Amazon](https://www.amazon.de/dp/B0H3VKJYY2?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [St. Ives Apricot Scrub](https://lovi.care/skincare/de/p/st-ives/apricot-scrub/for/dry-skin) — Average fit
- [COSRX AHA/BHA Clarifying Treatment Toner](https://lovi.care/skincare/de/p/cosrx/aha-bha-clarifying-treatment-toner/for/oily-acne-prone-skin) — Superior fit — [€14.11 at Amazon](https://www.amazon.de/dp/B073P6BPF5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Dr. Dennis Gross Alpha Beta Universal Daily Peel](https://lovi.care/skincare/de/p/dr-dennis-gross/alpha-beta-universal-daily-peel/for/acne-prone-skin) — Superior fit — [€168.25 at Amazon](https://www.amazon.de/dp/B009QZ595Q?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Pixi Glow Tonic](https://lovi.care/skincare/de/p/pixi/glow-tonic/for/oily-skin) — Superior fit — [€19.32 at Lookfantastic](https://www.lookfantastic.de/p/pixi-glow-tonic-home-and-away-duo-exclusive/12312693/)
- [Good Molecules Overnight Exfoliating Treatment](https://lovi.care/skincare/de/p/good-molecules/overnight-exfoliating-treatment/for/oily-skin) — Superior fit — [€20.99 at Amazon](https://www.amazon.de/dp/B08TMDRF1L?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [CeraVe Skin Renewing Nightly Exfoliating Treatment](https://lovi.care/skincare/de/p/cerave/skin-renewing-nightly-exfoliating-treatment/for/acne-prone-skin) — High fit

### [Hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/de/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€150.00 at Amazon](https://www.amazon.de/dp/B0FPFJ16KT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use glycolic acid and hexapeptide together?

Keep [glycolic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid) and [hexapeptide](https://lovi.care/skincare/de/ingredients/hexapeptide) apart by using them in separate routines, such as morning and evening, because the low pH of glycolic acid may destabilize the peptide bonds and reduce their effectiveness.

### Which goes first, glycolic acid or hexapeptide?

Keep glycolic acid and hexapeptide apart by using them in separate steps or routines, such as applying one in the morning and the other at night. Mixing them in the same routine may destabilize the peptide and reduce its effectiveness due to the low pH of the acid.

### Are glycolic acid and hexapeptide good for sensitive skin?

Glycolic acid and hexapeptide should be kept apart in your routine because the low pH of glycolic acid may destabilize peptide bonds and reduce their effectiveness. Sensitive skin types should especially avoid combining them in the same routine, using them in separate steps or routines instead.

## Research on glycolic acid and hexapeptide

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019

## Other combinations

- Keep them apart: [Glycolic acid and benzoyl peroxide](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-benzoyl-peroxide)
- Keep them apart: [Glycolic acid and retinol](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-retinol)
- Depends on the strength: [Glycolic acid and niacinamide](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-niacinamide)
- Work well together: [Glycolic acid and sodium lactate](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-sodium-lactate)
- Work well together: [Glycolic acid and tromethamine](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-tromethamine)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/de/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/de/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/de/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/de/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/de/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/de/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/de/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/de/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/de/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/de/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/de/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-hyaluronic-acid)
- Work well together: [Glycolic acid and betaine](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-betaine)
- Work well together: [Glycolic acid and glycerin](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-glycerin)
- Depends on the strength: [Glycolic acid and hyaluronic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/de/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/de/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/de/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/de/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/de/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/de/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Glycolic acid and bio-placenta peptides](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-bio-placenta-peptides)
- Keep them apart: [Glycolic acid and carnosine](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-carnosine)
- Keep them apart: [Glycolic acid and collagen peptide](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-collagen-peptide)
- Keep them apart: [Glycolic acid and copper peptide](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-copper-peptide)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Glycolic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Glycolic acid and peptide-rich plasma](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-peptide-rich-plasma)
- Keep them apart: [Glycolic acid and triple peptide blend](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-triple-peptide-blend)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/de/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/de/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/de/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/de/ingredients/vitamin-e-and-hexapeptide)
- Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/de/ingredients/adapalene-and-glycolic-acid)
- Keep them apart: [Glycolic acid and granactive retinoid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-granactive-retinoid)
- Keep them apart: [Glycolic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Glycolic acid and pro-retinol](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-pro-retinol)
- Keep them apart: [Glycolic acid and retinal](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-retinal)
- Keep them apart: [Glycolic acid and retinoid blend](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-retinoid-blend)
- Keep them apart: [Glycolic acid and tretinoin](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-tretinoin)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/de/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/de/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/de/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/hexapeptide-and-tri-ceramide-complex)
- Work well together: [Glycolic acid and gluconolactone](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-gluconolactone)
- Work well together: [Glycolic acid and lactobionic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-lactobionic-acid)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-hexapeptide)
- Work well together: [Glycolic acid and cholesterol](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-cholesterol)
- Work well together: [Glycolic acid and lauric acid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-lauric-acid)
- Work well together: [Glycolic acid and linoleic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-linoleic-acid)
- Keep them apart: [Glycolic acid and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-tri-ceramide-complex)
- Work well together: [Glycolic acid and arginine](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-arginine)
- Work well together: [Glycolic acid and GABA](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-gaba)
- Work well together: [Glycolic acid and silk amino acids](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-silk-amino-acids)
- Work well together: [Glycolic acid and taurine](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-taurine)
- Work well together: [Glycolic acid and theanine](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-theanine)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/de/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/de/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/de/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/de/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Work well together: [Glycolic acid and ferulic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-ferulic-acid)
- Work well together: [Glycolic acid and vitamin E](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-vitamin-e)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/de/ingredients/hexapeptide-and-copper)
- Keep them apart: [Glycolic acid and azelaic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-azelaic-acid)
- Keep them apart: [Glycolic acid and salicylic acid](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-salicylic-acid)
- Work well together: [Glycolic acid and allantoin](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-allantoin)
- Work well together: [Glycolic acid and bisabolol](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-bisabolol)
- Work well together: [Glycolic acid and panthenol](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-panthenol)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/de/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/de/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/de/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide
- United Kingdom: https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-hexapeptide
- Ireland: https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-hexapeptide
- Germany: https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hexapeptide (this page)
- France: https://lovi.care/skincare/fr/ingredients/glycolic-acid-and-hexapeptide
- Italy: https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hexapeptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide
- Spain: https://lovi.care/skincare/es/ingredients/glycolic-acid-and-hexapeptide
- Canada: https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-hexapeptide
- Australia: https://lovi.care/skincare/au/ingredients/glycolic-acid-and-hexapeptide
- Singapore: https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-hexapeptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-hexapeptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/glycolic-acid-and-hexapeptide