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Copper peptide and protease

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Copper peptide and protease: keep them apart

Keep them apart

Use them at different times of day with copper peptides in the morning and protease at night, because they break each other down. Protease enzymes break down the bonds of copper peptides, making both ingredients completely useless on your skin. You can easily fix this by using one in your morning routine and the other at night.

Copper peptide products

Protease products

Questions and answers

Can you use copper peptide and protease together?

No, you should keep copper peptide and protease apart in your routine because the enzymes degrade peptide bonds and render the actives inactive. You can separate them into different routines or days to avoid this breakdown.

Which goes first, copper peptide or protease?

Keep copper peptide and protease apart in your routine because the protease may degrade the peptide and render it inactive. Use them at separate times of day if you choose to use both.

Are copper peptide and protease good for sensitive skin?

No, you should keep copper peptide and protease apart because proteolytic enzymes degrade peptide bonds and render the actives inactive. You should avoid enzymatic ingredients in peptide-containing formulations.

Research on copper peptide and protease

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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