# Acetyl hexapeptide-3 and zinc Page: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-zinc The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany. Keep them apart Use [zinc](https://lovi.care/skincare/de/ingredients/zinc) and [acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) at different times of day, applying zinc in the morning and the peptide at night, because they clash and cancel each other out. Zinc blocks the peptide from smoothing fine lines and keeping skin firm. The shopper can separate them into morning and evening routines to get the full benefits of both products. - [All about acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) - [All about zinc](https://lovi.care/skincare/de/ingredients/zinc) ### [Acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [€27.95 at Amazon](https://www.amazon.de/dp/B0C9DXGXZ3?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [€16.90 at Amazon](https://www.amazon.de/dp/B0BLHW7JZM?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Medik8 Liquid Peptides](https://lovi.care/skincare/de/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [€102.00 at Amazon](https://www.amazon.de/dp/B0DYV9VSDV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [La Mer The Treatment Lotion](https://lovi.care/skincare/de/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [€79.90 at Amazon](https://www.amazon.de/dp/B0B61KKT4K?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/de/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit - [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/de/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [€8.96 at Amazon](https://www.amazon.de/dp/B072JH13CD?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/de/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [€23.20 at Amazon](https://www.amazon.de/dp/B091MTKS35?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/de/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€77.95 at Amazon](https://www.amazon.de/dp/B09FG8TJDD?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [La Mer The Renewal Oil](https://lovi.care/skincare/de/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [€113.39 at Amazon](https://www.amazon.de/dp/B0FNKL2Y9Y?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/de/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [€69.00 at Lookfantastic](https://www.lookfantastic.de/p/estee-lauder-micro-essence-treatment-lotion-fresh-with-sakura-ferment-various-sizes/13496504/) - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/de/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [La Mer The Eye Concentrate](https://lovi.care/skincare/de/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [€124.58 at Amazon](https://www.amazon.de/dp/B085614WX5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ### [Zinc](https://lovi.care/skincare/de/ingredients/zinc) products - [BYOMA Clarifying Serum](https://lovi.care/skincare/de/p/byoma/clarifying-serum/for/dry-skin) — High fit — [€27.47 at Amazon](https://www.amazon.de/dp/B0C7C8BZLM?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Minimalist Vitamin B5 10% Moisturizer](https://lovi.care/skincare/de/p/minimalist/vitamin-b5-10-moisturizer/for/mature-skin) — High fit - [Sunday Riley Saturn Sulfur Spot Treatment Mask](https://lovi.care/skincare/de/p/sunday-riley/saturn-sulfur-spot-treatment-mask/for/oily-acne-prone-skin) — Superior fit ## Questions and answers ### Can you use acetyl hexapeptide-3 and zinc together? Keep [acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) and [zinc](https://lovi.care/skincare/de/ingredients/zinc) apart in your routine because unchelated metal ions may [complex](https://lovi.care/skincare/de/ingredients/complex) with peptides and reduce their biological activity. ### Which goes first, acetyl hexapeptide-3 or zinc? Keep acetyl hexapeptide-3 and zinc apart in your routine because they may complex together and reduce biological activity. Use them at different times or separate routines. ### Are acetyl hexapeptide-3 and zinc good for sensitive skin? Keep acetyl hexapeptide-3 and zinc apart in your routine because zinc may complex with peptides and reduce their biological activity. ## Research on acetyl hexapeptide-3 and zinc - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019 - [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc · Journal of Controlled Release, 2025 - [Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32983333/) Zinc · The Journal of Clinical and Aesthetic Dermatology, 2020 - [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc · Clinical, Cosmetic and Investigational Dermatology, 2023 - [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017 - [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013 - [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc · Journal of Cosmetic Dermatology, 2026 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/pro-retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/retinal-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/tretinoin-and-acetyl-hexapeptide-3) - Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/vitamin-a-and-acetyl-hexapeptide-3) - Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/liposome-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-microcapsule) - Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/vitamin-c-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-betaine) - Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/glycerin-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid) - Depends on the strength: [Salicylic acid and zinc](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-zinc) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/panthenol-and-acetyl-hexapeptide-3) - Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/bakuchiol-and-acetyl-hexapeptide-3) - Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/arginine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-gaba) - Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3) - Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/taurine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-citric-acid) - Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-mandelic-acid) - Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3) - Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/green-tea-and-acetyl-hexapeptide-3) - Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/vitamin-e-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol) - Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-cholesterol) - Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) - Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-phytosterol) - Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-squalene) - Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-baking-soda) - Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-bleach) - Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide) - Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol) - Work well together: [Niacinamide and zinc](https://lovi.care/skincare/de/ingredients/niacinamide-and-zinc) - Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/copper-and-acetyl-hexapeptide-3) - Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/magnesium-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate) - Keep them apart: [Bio-placenta peptides and zinc](https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-zinc) - Keep them apart: [Zinc and collagen peptide](https://lovi.care/skincare/de/ingredients/zinc-and-collagen-peptide) - Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/de/ingredients/zinc-and-copper-peptide) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc) - Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/de/ingredients/zinc-and-hexapeptide-9) - Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/zinc-and-palmitoyl-pentapeptide-4) - Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/de/ingredients/zinc-and-palmitoyl-tripeptide-1) - Keep them apart: [Zinc and peptide-rich plasma](https://lovi.care/skincare/de/ingredients/zinc-and-peptide-rich-plasma) - Keep them apart: [Zinc and triple peptide blend](https://lovi.care/skincare/de/ingredients/zinc-and-triple-peptide-blend) - Work well together: [Benzoyl peroxide and zinc](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-zinc) - Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc - United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-zinc - Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-zinc - Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-zinc (this page) - France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-zinc - Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-zinc - Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-zinc - Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-zinc - Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-zinc - Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-zinc - Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-zinc - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-zinc - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-zinc