# Acetyl hexapeptide-3 and potassium hydroxide Page: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany. Keep them apart Use them at different times of day, applying [acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) first and [potassium hydroxide](https://lovi.care/skincare/de/ingredients/potassium-hydroxide) later, because they clash in acidity. The strong alkalinity breaks down the peptide, making it completely useless on your skin. You can space them out into separate routines or switch to a gentler product. - [All about acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) - [All about potassium hydroxide](https://lovi.care/skincare/de/ingredients/potassium-hydroxide) ### [Acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [€27.95 at Amazon](https://www.amazon.de/dp/B0C9DXGXZ3?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [€16.90 at Amazon](https://www.amazon.de/dp/B0BLHW7JZM?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Medik8 Liquid Peptides](https://lovi.care/skincare/de/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [€102.00 at Amazon](https://www.amazon.de/dp/B0DYV9VSDV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [La Mer The Treatment Lotion](https://lovi.care/skincare/de/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [€79.90 at Amazon](https://www.amazon.de/dp/B0B61KKT4K?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/de/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit - [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/de/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [€8.96 at Amazon](https://www.amazon.de/dp/B072JH13CD?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/de/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [€23.20 at Amazon](https://www.amazon.de/dp/B091MTKS35?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/de/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€77.95 at Amazon](https://www.amazon.de/dp/B09FG8TJDD?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [La Mer The Renewal Oil](https://lovi.care/skincare/de/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [€113.39 at Amazon](https://www.amazon.de/dp/B0FNKL2Y9Y?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/de/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [€69.00 at Lookfantastic](https://www.lookfantastic.de/p/estee-lauder-micro-essence-treatment-lotion-fresh-with-sakura-ferment-various-sizes/13496504/) - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/de/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [La Mer The Eye Concentrate](https://lovi.care/skincare/de/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [€124.58 at Amazon](https://www.amazon.de/dp/B085614WX5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ### [Potassium hydroxide](https://lovi.care/skincare/de/ingredients/potassium-hydroxide) products - [Glytone Mild Gel Cleanser](https://lovi.care/skincare/de/p/glytone/mild-gel-cleanser/for/dark-spots) — High fit ## Questions and answers ### Can you use acetyl hexapeptide-3 and potassium hydroxide together? Keep [acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3) and [potassium hydroxide](https://lovi.care/skincare/de/ingredients/potassium-hydroxide) apart because mixing peptides with highly alkaline environments causes them to lose stability and activity. Acetyl hexapeptide-3 applied twice daily for 4 weeks helps reduce wrinkles and skin roughness. [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/) ### Which goes first, acetyl hexapeptide-3 or potassium hydroxide? Keep acetyl hexapeptide-3 and potassium hydroxide apart because alkaline environments destabilize peptides. Use them in separate routines to maintain peptide effectiveness. ### Are acetyl hexapeptide-3 and potassium hydroxide good for sensitive skin? Acetyl hexapeptide-3 and potassium hydroxide should be kept apart because highly alkaline environments cause peptides to lose stability and activity. Acetyl hexapeptide-3 applied twice daily for four weeks helps decrease skin roughness and provides anti-wrinkle effects. [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/) ## Research on acetyl hexapeptide-3 and potassium hydroxide - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019 - [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017 - [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/pro-retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/retinal-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/tretinoin-and-acetyl-hexapeptide-3) - Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/vitamin-a-and-acetyl-hexapeptide-3) - Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/liposome-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-microcapsule) - Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/vitamin-c-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-betaine) - Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/glycerin-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/panthenol-and-acetyl-hexapeptide-3) - Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/bakuchiol-and-acetyl-hexapeptide-3) - Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/arginine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-gaba) - Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3) - Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/taurine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-citric-acid) - Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-mandelic-acid) - Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3) - Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/green-tea-and-acetyl-hexapeptide-3) - Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/vitamin-e-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol) - Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-cholesterol) - Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) - Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-phytosterol) - Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-squalene) - Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/salicylic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-baking-soda) - Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-bleach) - Keep them apart: [Bio-placenta peptides and potassium hydroxide](https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-potassium-hydroxide) - Keep them apart: [Potassium hydroxide and collagen peptide](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-collagen-peptide) - Keep them apart: [Potassium hydroxide and copper peptide](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-copper-peptide) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/de/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Potassium hydroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Potassium hydroxide and peptide-rich plasma](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-peptide-rich-plasma) - Keep them apart: [Potassium hydroxide and triple peptide blend](https://lovi.care/skincare/de/ingredients/potassium-hydroxide-and-triple-peptide-blend) - Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol) - Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/copper-and-acetyl-hexapeptide-3) - Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/magnesium-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-zinc) - Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3) - Keep them apart: [Vitamin C and potassium hydroxide](https://lovi.care/skincare/de/ingredients/vitamin-c-and-potassium-hydroxide) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/de/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide (this page) - France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide