# Shu Uemura vs Sesderma

Page: https://lovi.care/skincare/de/compare/shu-uemura-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Shu Uemura and Sesderma are distinguished skincare brands, hailing from Japan and Spain respectively, that offer meticulously crafted formulas for diverse complexions. The former is celebrated for its transformative makeup removers, including a cleansing oil ideal for acne-prone skin, while the latter is beloved for advanced [serums](https://lovi.care/skincare/de/ingredients/serum) like the Azelac RU Serum that address similar concerns. Shu Uemura suits all skin types best through gentle and effective offerings, whereas Sesderma is tailored primarily for sensitive, hyperpigmented, and aging skin. Ultimately, both houses differ in their geographical origins, founding years, and targeted botanical or active compounds.

Shu Uemura is a Japanese skincare brand founded in 1967 and owned by L'Oréal S.A. since 2003.

[loreal-finance.com](https://www.loreal-finance.com/eng/2024-universal-registration-document/en/article/12/) [pitchbook.com](https://pitchbook.com/profiles/company/168869-71) [en.wikipedia.org](https://en.wikipedia.org/wiki/Shu_Uemura) [sec.gov](https://www.sec.gov/Archives/edgar/vprr/0303/03037595.pdf)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Shu Uemura and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg6ced1d2e51).

### Popular Shu Uemura vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/de/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.16 at Amazon](https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### Shu Uemura

- [cleansing oil](https://lovi.care/skincare/de/p/shu-uemura/cleansing-oil/for/dry-sensitive-skin) — Average fit — [€40.00 at Amazon](https://www.amazon.de/dp/B0DNJKPSB8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Shu Uemura or Sesderma: which is better?

For acne-prone skin or dark spots, Sesderma is better because the products on this page achieve a High Lovi fit level, whereas Shu Uemura only reaches Low or Caution. However, Sesderma's Azelac RU [Serum](https://lovi.care/skincare/de/ingredients/serum) contains fragrance, while Shu Uemura lists no fragrance in its cleansing oil.

### What is the difference between Shu Uemura and Sesderma?

Shu Uemura offers cleansing oil, which gets an Average Lovi fit for dry and sensitive skin, whereas Sesderma features Azelac RU Serum, which achieves a High Lovi fit for acne-prone skin and skin with dark spots. The products on this page by Shu Uemura list no fragrance, while Sesderma includes fragrance in its serum.

### Which is more affordable, Shu Uemura or Sesderma?

Neither Shu Uemura nor Sesderma has pricing information on this page, so affordability cannot be compared here.

### Which causes fewer breakouts, Shu Uemura or Sesderma?

For acne-prone skin, the products on this page by Sesderma achieve a High fit, whereas Shu Uemura cleansing oil earns a Low fit and requires caution. [Azelaic acid](https://lovi.care/skincare/de/ingredients/azelaic-acid) helps treat acne vulgaris.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### How do the founding years and countries of origin compare between Shu Uemura and Sesderma?

Shu Uemura was founded in Japan in 1967, whereas Sesderma was founded in Spain in 1989.

### Which brand offers a cleansing oil, and which brand offers the Azelac RU Serum?

Shu Uemura offers the cleansing oil, while Sesderma offers the Azelac RU Serum. Every product on the Shu Uemura page lists no fragrance, whereas the Azelac RU Serum by Sesderma includes fragrance.

### How does the presence of fragrance differ between the products of Shu Uemura and Sesderma?

Every product on this page by Shu Uemura lists no fragrance in its ingredients. In contrast, none of the products on this page by Sesderma list no fragrance, as the Azelac RU Serum contains fragrance.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/16778793/) Squalane · The Journal of Investigative Dermatology, 2006
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica seed oil · Journal of Ethnopharmacology, 2007
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Japanese skincare: [Shu Uemura](https://lovi.care/skincare/de/brands/shu-uemura)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/de/brands/sesderma)

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- [The Ordinary vs Shu Uemura](https://lovi.care/skincare/de/compare/the-ordinary-vs-shu-uemura)
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- [La Roche-Posay vs Shu Uemura](https://lovi.care/skincare/de/compare/la-roche-posay-vs-shu-uemura)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/de/compare/la-roche-posay-vs-sesderma)
- [Dr. Althea vs Shu Uemura](https://lovi.care/skincare/de/compare/dr-althea-vs-shu-uemura)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/de/compare/dr-althea-vs-sesderma)
- [Some By Mi vs Shu Uemura](https://lovi.care/skincare/de/compare/some-by-mi-vs-shu-uemura)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/de/compare/some-by-mi-vs-sesderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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