# Principia vs Mesoestetic Page: https://lovi.care/skincare/de/compare/principia-vs-mesoestetic The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany. Principia and Mesoestetic are two thoughtful skincare lines known for their precise formulas and effective daily care. The first brand is widely loved for its thoughtful cleansers, including the Gel de Limpeza GL-01, which suits balanced to oily and acne-prone skin best to help maintain a healthy, balanced complexion. Meanwhile, the second option is a Spanish skincare brand founded in 1984 that is beloved for its targeted [serums](https://lovi.care/skincare/de/ingredients/serum), featuring standout solutions like the Cosmelan 2 for acne-prone skin. Both choices deliver balanced nourishment, though their compositions differ to suit either balanced skin or mature, sensitive, and uneven skin best. Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L.. [mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk) This page compares some of the most popular Principia and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg23c2c155cb). ### Popular Principia vs Mesoestetic products #### Mesoestetic - [Cosmelan 2](https://lovi.care/skincare/de/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit #### Principia - [Gel de Limpeza GL-01](https://lovi.care/skincare/de/p/principia/gel-de-limpeza-gl-01/for/oily-skin) — Average fit ## Questions and answers ### Principia or Mesoestetic: which is better? Neither brand is universally better, as both offer average fit levels for most skin types with the products on this page. Lovi rates both Principia and Mesoestetic with average suitability for oily, combination, and mature skin types. ### What is the difference between Principia and Mesoestetic? Principia was founded in 2020 by Viziera Participações Ltda., whereas Mesoestetic was founded in 1984 in Spain and is owned by Mesoestetic Pharma Group, S.L. Every product on this page from both brands lists no fragrance in its ingredients. ### Which is more affordable, Principia or Mesoestetic? Neither Principia nor Mesoestetic is described on this page regarding affordability, as pricing information is not included in the page facts. ### Which causes fewer breakouts, Principia or Mesoestetic? Both Principia and Mesoestetic offer products on this page that generally achieve an average Lovi fit for acne-prone and oily acne-prone skin types. Neither brand lists a specific breakout-prevention claim for the items on this page. ### In what year was each brand founded? Mesoestetic was founded in 1984, while the founding year for Principia is not available on this page, as it was established in 2020. ### Do any of the products from either brand contain fragrance? Every product on this page from both Principia and Mesoestetic lists no fragrance in its ingredients. ### Which skin types are best suited for the Cosmelan 2 serum compared to the GL-01 cleanser? Neither the Cosmelan 2 [serum](https://lovi.care/skincare/de/ingredients/serum) nor the GL-01 cleanser has any skin type where it reaches a High or Superior Lovi fit on this page, as both products score an Average fit across multiple skin types including oily, combination, and mature skin. Lovi rates the Cosmelan 2 serum as Average for acne-prone skin, and rates the GL-01 cleanser as Low for that same skin type. ## Research behind their key ingredients - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018 - [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020 - [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024 - [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026 ## The brands - Skincare: [Principia](https://lovi.care/skincare/de/brands/principia) - Spanish skincare: [Mesoestetic](https://lovi.care/skincare/de/brands/mesoestetic) ## More comparisons - [SKIN1004 vs Principia](https://lovi.care/skincare/de/compare/skin1004-vs-principia) - [SKIN1004 vs Mesoestetic](https://lovi.care/skincare/de/compare/skin1004-vs-mesoestetic) - [Anua vs Principia](https://lovi.care/skincare/de/compare/anua-vs-principia) - [Anua vs Mesoestetic](https://lovi.care/skincare/de/compare/anua-vs-mesoestetic) - [Medicube vs Principia](https://lovi.care/skincare/de/compare/medicube-vs-principia) - [Medicube vs Mesoestetic](https://lovi.care/skincare/de/compare/medicube-vs-mesoestetic) - [The Ordinary vs Principia](https://lovi.care/skincare/de/compare/the-ordinary-vs-principia) - [The Ordinary vs Mesoestetic](https://lovi.care/skincare/de/compare/the-ordinary-vs-mesoestetic) - [Beauty of Joseon vs Principia](https://lovi.care/skincare/de/compare/beauty-of-joseon-vs-principia) - [Beauty of Joseon vs Mesoestetic](https://lovi.care/skincare/de/compare/beauty-of-joseon-vs-mesoestetic) - [COSRX vs Principia](https://lovi.care/skincare/de/compare/cosrx-vs-principia) - [COSRX vs Mesoestetic](https://lovi.care/skincare/de/compare/cosrx-vs-mesoestetic) - [CeraVe vs Principia](https://lovi.care/skincare/de/compare/cerave-vs-principia) - [CeraVe vs Mesoestetic](https://lovi.care/skincare/de/compare/cerave-vs-mesoestetic) - [La Roche-Posay vs Principia](https://lovi.care/skincare/de/compare/la-roche-posay-vs-principia) - [La Roche-Posay vs Mesoestetic](https://lovi.care/skincare/de/compare/la-roche-posay-vs-mesoestetic) - [Dr. Althea vs Principia](https://lovi.care/skincare/de/compare/dr-althea-vs-principia) - [Dr. Althea vs Mesoestetic](https://lovi.care/skincare/de/compare/dr-althea-vs-mesoestetic) - [Some By Mi vs Principia](https://lovi.care/skincare/de/compare/some-by-mi-vs-principia) - [Some By Mi vs Mesoestetic](https://lovi.care/skincare/de/compare/some-by-mi-vs-mesoestetic) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/principia-vs-mesoestetic - United Kingdom: https://lovi.care/skincare/uk/compare/principia-vs-mesoestetic - Ireland: https://lovi.care/skincare/ie/compare/principia-vs-mesoestetic - Germany: https://lovi.care/skincare/de/compare/principia-vs-mesoestetic (this page) - France: https://lovi.care/skincare/fr/compare/principia-vs-mesoestetic - Italy: https://lovi.care/skincare/it/compare/principia-vs-mesoestetic - Netherlands: https://lovi.care/skincare/nl/compare/principia-vs-mesoestetic - Spain: https://lovi.care/skincare/es/compare/principia-vs-mesoestetic - Canada: https://lovi.care/skincare/ca/compare/principia-vs-mesoestetic - Australia: https://lovi.care/skincare/au/compare/principia-vs-mesoestetic - Singapore: https://lovi.care/skincare/sg/compare/principia-vs-mesoestetic - Saudi Arabia: https://lovi.care/skincare/sa/compare/principia-vs-mesoestetic - United Arab Emirates: https://lovi.care/skincare/ae/compare/principia-vs-mesoestetic