# Medicube vs Trilogy

Page: https://lovi.care/skincare/de/compare/medicube-vs-trilogy

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Medicube and Trilogy are distinct skincare lines offering thoughtfully formulated moisturizers, [serums](https://lovi.care/skincare/de/ingredients/serum), toners, masks, and gentle cleansers. The Korean brand founded in 2016 and owned by APR Corp. harnesses [niacinamide](https://lovi.care/skincare/de/ingredients/niacinamide), [collagen](https://lovi.care/skincare/de/ingredients/collagen), and [hyaluronic acid](https://lovi.care/skincare/de/ingredients/hyaluronic-acid) to suit dry and oily acne-prone skin best, while the other relies on high-performing formulas to suit dry, balanced, and sensitive skin types best. Both provide targeted solutions like the AGE-R Booster Gel and [Vitamin C](https://lovi.care/skincare/de/ingredients/vitamin-c) Ceramide Night Cream for acne-prone skin, the Deep Peptide Radiance Mask and [Rosehip](https://lovi.care/skincare/de/ingredients/rosehip-oil) Cream Cleanser for dark spots, and the Deep Lifting Peptide Eye Cream and Line Smoothing Day Cream for mature skin. Ultimately, they differ through the former's emphasis on profound results from key ingredients and the latter's focus on gentle, natural care.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

[medicubereviews.co.uk](https://medicubereviews.co.uk/medicube/story/) [glossy.co](https://www.glossy.co/beauty/medicubes-founder-on-the-products-and-people-that-fueled-the-k-beauty-brands-booming-year/)

This page compares some of the most popular Medicube and Trilogy products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg0765e5b58d).

### Popular Medicube vs Trilogy products

#### Medicube

- [Zero Pore Pad](https://lovi.care/skincare/de/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.de/dp/B09V7Z4TJG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Peptide Serum](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [€16.60 at Amazon](https://www.amazon.de/dp/B0DBF65JYY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Collagen Jelly Cream](https://lovi.care/skincare/de/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [€19.00 at Amazon](https://www.amazon.de/dp/B0CM2PPNMW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Collagen Night Wrapping Mask](https://lovi.care/skincare/de/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit — [€12.15 at Amazon](https://www.amazon.de/dp/B0BRMYHMS5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Collagen Gel Mask](https://lovi.care/skincare/de/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin) — High fit — [€12.99 at Amazon](https://www.amazon.de/dp/B0DT6Y6QC5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [DEEP VITA-C CAPSULE CREAM](https://lovi.care/skincare/de/p/medicube/deep-vita-c-capsule-cream/for/sensitive-skin) — Average fit — [€16.77 at Amazon](https://www.amazon.de/dp/B0D2Z3GGCY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [TRIPLE COLLAGEN CREAM](https://lovi.care/skincare/de/p/medicube/triple-collagen-cream/for/mature-skin) — Average fit — [€17.70 at Amazon](https://www.amazon.de/dp/B0BPXT3GBN?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Zero Foam Cleanser](https://lovi.care/skincare/de/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [€12.79 at Amazon](https://www.amazon.de/dp/B0DYTQ5GYQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### Trilogy

- [Rosehip Cream Cleanser](https://lovi.care/skincare/de/p/trilogy/rosehip-cream-cleanser/for/sensitive-skin) — High fit
- [Line Smoothing Day Cream](https://lovi.care/skincare/de/p/trilogy/line-smoothing-day-cream/for/dry-skin) — High fit
- [Vitamin C Ceramide Night Cream](https://lovi.care/skincare/de/p/trilogy/vitamin-c-ceramide-night-cream/for/mature-skin) — High fit

## People Say

Medicube

Trilogy

- Hydration and Moisture Mostly Mentioned Mostly Mentioned “Keeps skin moisturized — Trilogy Vitamin C Ceramide Night Cream” “Leaves skin thoroughly moisturised — Trilogy Line Smoothing Day Cream” “Feels moisturizing — Trilogy Rosehip Cream Cleanser” “skin feels bouncier and hydrated — Medicube PDRN Pink Peptide Serum”
- Texture and Consistency Sometimes Noted Mostly Mentioned “Silky cream consistency — Trilogy Rosehip Cream Cleanser” “Luxuriously rich — Trilogy Vitamin C Ceramide Night Cream” “Not greasy — Trilogy Line Smoothing Day Cream” “Rich but absorbs well — Medicube TRIPLE COLLAGEN CREAM”
- Soothing and Gentle Formulas Often Mentioned Mostly Mentioned “Doesn't irritate my sensitive skin — Trilogy Rosehip Cream Cleanser” “Nothing irritated my skin — Trilogy Line Smoothing Day Cream” “refreshing sensation — Medicube PDRN Pink Collagen Gel Mask”
- Glow and Brightening Often Mentioned Often Mentioned “gave me instant glass skin — Medicube Collagen Jelly Cream” “woke up with glowing skin — Medicube Collagen Night Wrapping Mask” “Dark spots go away faster — Medicube Deep Vita C Pad” “Wake to a glowing complexion — Trilogy Vitamin C Ceramide Night Cream”
- Packaging and Usability Sometimes Noted Sometimes Noted “dries super fast — Medicube Zero Pore Blackhead Mud Mask” “tweezers included are hygienic — Medicube Zero Pore Pad” “perfect slip for my device — Medicube Collagen Jelly Cream” “Supports regeneration of healthy skin barrier — Trilogy Vitamin C Ceramide Night Cream”
- Skin Texture and Smoothness Often Mentioned Not noted “gives my skin a smooth, glass-like finish — Medicube Zero Pore Pad” “skin feels smoother — Medicube PDRN Pink Peptide Serum” “skin feels baby soft — Medicube Zero Pore Blackhead Mud Mask”
- Application and Removal Issues Sometimes Noted Mostly Mentioned “messy — Medicube PDRN Pink Collagen Gel Mask” “takes forever to dry down — Medicube Collagen Jelly Cream” “lifted around the nose/eyes — Medicube PDRN Pink Collagen Gel Mask” “Not effective for heavy makeup — Trilogy Rosehip Cream Cleanser”
- Sticky or Heavy Residue Often Mentioned Rarely Noted “Does leave that kind of residue — Trilogy Vitamin C Ceramide Night Cream” “hair sticks to my face — Medicube Collagen Jelly Cream”
- Strong or Unpleasant Scent Often Mentioned Sometimes Noted “If you are sensitive to fragrances, you might find it irritating — Trilogy Rosehip Cream Cleanser” “Scent is awful — Trilogy Line Smoothing Day Cream” “slightly fishy smell — Medicube PDRN Pink Peptide Serum”

## Questions and answers

### Medicube or Trilogy: which is better?

Medicube is better for glow and brightening, skin texture and smoothness, and packaging and usability, while Trilogy is better for hydration and moisture, texture and consistency, and soothing and gentle formulas. [Niacinamide](https://lovi.care/skincare/de/ingredients/niacinamide) helps reduce cutaneous pigmentation and suppress melanosome transfer.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What is the difference between Medicube and Trilogy?

Medicube was founded in 2016 in South Korea and is owned by APR Corp., whereas Trilogy was founded in 2002 and is owned by CITIC Capital Holdings Limited. Medicube excels in glow and brightening, packaging and usability, and skin texture and smoothness, while Trilogy performs better in hydration and moisture, texture and consistency, and soothing and gentle formulas.

### Medicube or Trilogy: which cleanser is better?

Medicube offers more cleansers with a High Lovi fit across acne-prone, oily, and mature skin types compared to Trilogy, which features only one cleanser.

### Which is more affordable, Medicube or Trilogy?

The page does not provide pricing or affordability comparisons between Medicube and Trilogy products.

### Which causes fewer breakouts, Medicube or Trilogy?

The page does not provide data comparing the likelihood of breakouts between Medicube and Trilogy.

### How do the fragrance options differ between Medicube and Trilogy products?

Medicube offers significantly more fragrance-free options, with 23 out of 25 products on this page listing no fragrance. In contrast, only 1 of the 3 Trilogy products on this page lists no fragrance.

### Which brand performs better in terms of soothing and gentle formulas according to reviewers?

Trilogy performs better than Medicube in terms of soothing and gentle formulas according to reviewers.

### What are the founding years and parent companies of Medicube and Trilogy?

Medicube was founded in 2016 in South Korea and is owned by APR Corp., whereas Trilogy was founded in 2002 and has been owned by CITIC Capital Holdings Limited since 2018.

### Medicube or Trilogy: which moisturizer is better?

Medicube offers a wider selection of moisturizers with specialized options for mature and dry skin, whereas Trilogy provides hydrating and brightening moisturizers like its [Vitamin C](https://lovi.care/skincare/de/ingredients/vitamin-c) Ceramide Night Cream. Reviewers note that Trilogy performs better for overall hydration and moisture, while Medicube stands out for glow and brightening.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/37377400/) Exosome cica · Journal of Cosmetic Dermatology, 2023
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Vitamin c derivatives · Experimental Dermatology, 2003
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Aha · Journal of Dermatological Science, 2017
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Tea tree oil reduces histamine-induced skin inflammation](https://pubmed.ncbi.nlm.nih.gov/12452873/) Tree · The British Journal of Dermatology, 2002
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica flower extract · Journal of Ethnopharmacology, 2007
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [Protective effects of Camellia japonica flower extract against urban air pollutants](https://pubmed.ncbi.nlm.nih.gov/30691451/) Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28341613/) Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen extract · Nutrients, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Vitamin c derivatives · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid, Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract, Madecassoside, Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine](https://pubmed.ncbi.nlm.nih.gov/34284096/) Sophora angustifolia root extract, Sophora flavescens root extract · European Journal of Pharmaceutical Sciences, 2021
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis flower extract · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex](https://pubmed.ncbi.nlm.nih.gov/39205505/) Succinic acid · Journal of Cosmetic Dermatology, 2024
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract](https://pubmed.ncbi.nlm.nih.gov/33410284/) Camellia japonica flower extract · FEBS Open Bio, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial](https://pubmed.ncbi.nlm.nih.gov/37726676/) Portulaca oleracea extract · BMC Oral Health, 2023
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed extract · Skin Pharmacology and Physiology, 2007
- [Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract](https://pubmed.ncbi.nlm.nih.gov/35403355/) Grape seed extract · Journal of Cosmetic Dermatology, 2022
- [Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study](https://pubmed.ncbi.nlm.nih.gov/32379165/) Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Composition characterization and clinical efficacy study of a salmon egg extract](https://pubmed.ncbi.nlm.nih.gov/23738607/) Salmon egg extract · International Journal of Cosmetic Science, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate vitamin e · Scientific Reports, 2025
- [Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations](https://pubmed.ncbi.nlm.nih.gov/31435711/) Ethanolamine · Archives of Toxicology, 2019
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022
- [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) Sodium dna, Pdrn polydeoxyribonucleotide · International Journal of Molecular Sciences, 2025
- [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) Sodium dna · International Journal of Biological Macromolecules, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025
- [Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/41758783/) Ceramide iii · Skin Pharmacology and Physiology, 2026

## The brands

- Korean skincare: [Medicube](https://lovi.care/skincare/de/brands/medicube)
- Skincare: [Trilogy](https://lovi.care/skincare/de/brands/trilogy)

## More comparisons

- [SKIN1004 vs Medicube](https://lovi.care/skincare/de/compare/skin1004-vs-medicube)
- [SKIN1004 vs Trilogy](https://lovi.care/skincare/de/compare/skin1004-vs-trilogy)
- [Anua vs Medicube](https://lovi.care/skincare/de/compare/anua-vs-medicube)
- [Anua vs Trilogy](https://lovi.care/skincare/de/compare/anua-vs-trilogy)
- [Medicube vs The Ordinary](https://lovi.care/skincare/de/compare/medicube-vs-the-ordinary)
- [Medicube vs Beauty of Joseon](https://lovi.care/skincare/de/compare/medicube-vs-beauty-of-joseon)
- [Medicube vs COSRX](https://lovi.care/skincare/de/compare/medicube-vs-cosrx)
- [Medicube vs CeraVe](https://lovi.care/skincare/de/compare/medicube-vs-cerave)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/de/compare/medicube-vs-la-roche-posay)
- [Medicube vs Dr. Althea](https://lovi.care/skincare/de/compare/medicube-vs-dr-althea)
- [Medicube vs Some By Mi](https://lovi.care/skincare/de/compare/medicube-vs-some-by-mi)
- [Medicube vs Torriden](https://lovi.care/skincare/de/compare/medicube-vs-torriden)
- [Medicube vs celimax](https://lovi.care/skincare/de/compare/medicube-vs-celimax)
- [Medicube vs Purito](https://lovi.care/skincare/de/compare/medicube-vs-purito)
- [Medicube vs Cetaphil](https://lovi.care/skincare/de/compare/medicube-vs-cetaphil)
- [Medicube vs Paula's Choice](https://lovi.care/skincare/de/compare/medicube-vs-paula-s-choice)
- [Medicube vs Neutrogena](https://lovi.care/skincare/de/compare/medicube-vs-neutrogena)
- [Medicube vs Kiehl's](https://lovi.care/skincare/de/compare/medicube-vs-kiehl-s)
- [Medicube vs Caudalie](https://lovi.care/skincare/de/compare/medicube-vs-caudalie)
- [Medicube vs Dermalogica](https://lovi.care/skincare/de/compare/medicube-vs-dermalogica)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medicube-vs-trilogy
- United Kingdom: https://lovi.care/skincare/uk/compare/medicube-vs-trilogy
- Ireland: https://lovi.care/skincare/ie/compare/medicube-vs-trilogy
- Germany: https://lovi.care/skincare/de/compare/medicube-vs-trilogy (this page)
- France: https://lovi.care/skincare/fr/compare/medicube-vs-trilogy
- Italy: https://lovi.care/skincare/it/compare/medicube-vs-trilogy
- Netherlands: https://lovi.care/skincare/nl/compare/medicube-vs-trilogy
- Spain: https://lovi.care/skincare/es/compare/medicube-vs-trilogy
- Canada: https://lovi.care/skincare/ca/compare/medicube-vs-trilogy
- Australia: https://lovi.care/skincare/au/compare/medicube-vs-trilogy
- Singapore: https://lovi.care/skincare/sg/compare/medicube-vs-trilogy
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medicube-vs-trilogy
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medicube-vs-trilogy