# Medicube vs Clinique

Page: https://lovi.care/skincare/de/compare/medicube-vs-clinique

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Medicube and Clinique are esteemed skincare brands originating from South Korea and America, respectively. The Korean brand is known for moisturizers, [serums](https://lovi.care/skincare/de/ingredients/serum), toners, and masks featuring [niacinamide](https://lovi.care/skincare/de/ingredients/niacinamide), [collagen](https://lovi.care/skincare/de/ingredients/collagen), and [hyaluronic acid](https://lovi.care/skincare/de/ingredients/hyaluronic-acid), while the American brand offers moisturizers, serums, makeup removers, and eye products utilizing hyaluronic acid, [glycerin](https://lovi.care/skincare/de/ingredients/glycerin), and [caffeine](https://lovi.care/skincare/de/ingredients/caffeine). Both choices suit dry skin and oily skin best, though the former focuses more on acne-prone and mature complexions with targeted gels, peels, and creams, whereas the latter emphasizes sensitive and oil-free solutions. They differ fundamentally in their foundational ingredients and regional heritage, yet both deliver balanced hydration and targeted rejuvenation.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

[medicubereviews.co.uk](https://medicubereviews.co.uk/medicube/story/) [glossy.co](https://www.glossy.co/beauty/medicubes-founder-on-the-products-and-people-that-fueled-the-k-beauty-brands-booming-year/)

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Clinique) [elcompanies.com](https://www.elcompanies.com/en/who-we-are/our-heritage) [businesswire.com](https://www.businesswire.com/news/home/20261019083802/en/The-Este-Lauder-Companies-Appoints-Krista-Lee-Berger-Senior-Vice-President-Global-Marketing-Clinique) [glossy.co](https://www.glossy.co/beauty/glossy-pop-newsletter-clinique-launches-first-ever-creator-led-campaign/)

This page compares some of the most popular Medicube and Clinique products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgf65577025b).

### Popular Medicube vs Clinique products

#### Medicube

- [Zero Pore Pad](https://lovi.care/skincare/de/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.de/dp/B09V7Z4TJG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Peptide Serum](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [€16.60 at Amazon](https://www.amazon.de/dp/B0DBF65JYY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Collagen Jelly Cream](https://lovi.care/skincare/de/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [€19.00 at Amazon](https://www.amazon.de/dp/B0CM2PPNMW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Collagen Night Wrapping Mask](https://lovi.care/skincare/de/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit — [€12.15 at Amazon](https://www.amazon.de/dp/B0BRMYHMS5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Collagen Gel Mask](https://lovi.care/skincare/de/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin) — High fit — [€12.99 at Amazon](https://www.amazon.de/dp/B0DT6Y6QC5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [DEEP VITA-C CAPSULE CREAM](https://lovi.care/skincare/de/p/medicube/deep-vita-c-capsule-cream/for/sensitive-skin) — Average fit — [€16.77 at Amazon](https://www.amazon.de/dp/B0D2Z3GGCY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [TRIPLE COLLAGEN CREAM](https://lovi.care/skincare/de/p/medicube/triple-collagen-cream/for/mature-skin) — Average fit — [€17.70 at Amazon](https://www.amazon.de/dp/B0BPXT3GBN?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Zero Foam Cleanser](https://lovi.care/skincare/de/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [€12.79 at Amazon](https://www.amazon.de/dp/B0DYTQ5GYQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### Clinique

- [moisture surge](https://lovi.care/skincare/de/p/clinique/moisture-surge/for/sensitive-skin) — High fit
- [Take The Day Off Cleansing Balm](https://lovi.care/skincare/de/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€22.53 at Amazon](https://www.amazon.de/dp/B07D5C86RX?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Lotion+](https://lovi.care/skincare/de/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin) — Average fit — [€20.97 at Amazon](https://www.amazon.de/dp/B00CVZ3NJ2?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [All About Eyes](https://lovi.care/skincare/de/p/clinique/all-about-eyes/for/dry-skin) — High fit — [€25.95 at Amazon](https://www.amazon.de/dp/B000OUTR32?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/de/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [€24.46 at Amazon](https://www.amazon.de/dp/B003JRI3OG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/de/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€77.95 at Amazon](https://www.amazon.de/dp/B09FG8TJDD?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Moisture Surge Overnight Mask](https://lovi.care/skincare/de/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit — [€24.50 at Amazon](https://www.amazon.de/dp/B00HSZRQQQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Clarifying Lotion 2](https://lovi.care/skincare/de/p/clinique/clarifying-lotion-2/for/oily-acne-prone-skin) — Average fit — [€29.95 at Amazon](https://www.amazon.de/dp/B01N184QGF?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## People Say

Medicube

Clinique

- Hydration and Moisture Mostly Mentioned Often Mentioned “skin feels bouncier and hydrated — Medicube PDRN Pink Peptide Serum” “glass skin — Medicube PDRN Pink Collagen Gel Mask” “woke up with baby soft skin — Medicube Collagen Jelly Cream” “Keeps my dry patches at bay all day — Clinique Dramatically Different Moisturizing Lotion+”
- Gentle and Sensitive Skin Care Sometimes Noted Mostly Mentioned “never irritated my eyes — Clinique All About Eyes” “No stinging eyes — Clinique Take The Day Off Cleansing Balm” “cools the heat in my cheeks — Clinique Redness Solutions Daily Relief Cream” “Did not cause any irritation — Medicube Red Foam Cleanser”
- Cleansing and Exfoliation Often Mentioned Often Mentioned “Melts waterproof mascara — Clinique Take The Day Off Cleansing Balm” “gentle enough for everyday — Clinique 7 Day Scrub Cream Rinse-Off Formula” “You will see the dirt with one wipe — Clinique Clarifying Lotion 2” “Pores drastically reduced — Medicube Zero Foam Cleanser”
- Skin Texture and Smoothing Often Mentioned Sometimes Noted “gives my skin a smooth, glass-like finish — Medicube Zero Pore Pad” “skin feels smoother — Medicube PDRN Pink Peptide Serum” “skin feels baby soft — Medicube Zero Pore Blackhead Mud Mask” “skin feels silky smooth — Clinique Smart Clinical Repair Wrinkle Correcting Serum”
- Lightweight and Fast Absorption Not noted Mostly Mentioned “sinks in immediately — Clinique moisture surge” “sinks in instantly — Clinique Dramatically Different Moisturizing Gel” “Absorbs quickly without feeling sticky — Clinique Dramatically Different Moisturizing Lotion+”
- Glow and Radiance Often Mentioned Rarely Noted “gave me instant glass skin — Medicube Collagen Jelly Cream” “woke up with glowing skin — Medicube Collagen Night Wrapping Mask” “Dark spots go away faster — Medicube Deep Vita C Pad” “wake up glowing — Clinique Moisture Surge Overnight Mask”
- Price and Value Sometimes Noted Often Mentioned “tube is tiny for the price — Medicube Collagen Night Wrapping Mask” “price is steep — Medicube PDRN Pink Collagen Gel Mask” “price is a bit steep — Medicube Red Succinic Acid Peeling Pad” “jar is too small for the cost — Clinique moisture surge”
- Sticky or Heavy Residue Often Mentioned Rarely Noted “hard to rinse off — Clinique 7 Day Scrub Cream Rinse-Off Formula” “Left an oily film on my T-zone — Clinique Dramatically Different Moisturizing Lotion+” “feels a bit sticky — Clinique Moisture Surge Overnight Mask” “hair sticks to my face — Medicube Collagen Jelly Cream”
- Strong Scent and Fragrance Often Mentioned Sometimes Noted “Smells like nail polish remover — Clinique Clarifying Lotion 2” “Smells like old oil — Clinique Take The Day Off Cleansing Balm” “Has a weird plastic-like smell — Clinique Dramatically Different Moisturizing Lotion+” “slightly fishy smell — Medicube PDRN Pink Peptide Serum”

### Medicube vs Clinique routines for dry skin

#### Medicube-focused routine

- Cleanser: [Zero Foam Cleanser](https://lovi.care/skincare/de/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [€12.79 at Amazon](https://www.amazon.de/dp/B0DYTQ5GYQ?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/de/p/medicube/triple-collagen-toner/for/dry-skin) — High fit — [€11.64 at Amazon](https://www.amazon.de/dp/B085VS2J3T?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/de/p/medicube/age-r-booster-gel/for/dry-skin) — Superior fit — [€16.99 at Amazon](https://www.amazon.de/dp/B0H4MHPRLG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Australian Gold Botanical Lotion SPF 30](https://lovi.care/skincare/de/p/australian-gold/botanical-lotion-spf-30/for/dry-skin) — Superior fit — [€21.04 at Amazon](https://www.amazon.de/dp/B0DV9RH665?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/de/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [€10.97 at Amazon](https://www.amazon.de/dp/B084Q16G8D?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [One Day Exosome Shot 2000](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/dry-skin) — High fit — [€16.00 at Amazon](https://www.amazon.de/dp/B0FNRSCSBG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Deep Peptide Radiance Mask](https://lovi.care/skincare/de/p/medicube/deep-peptide-radiance-mask/for/dry-skin) — High fit — [€7.99 at Amazon](https://www.amazon.de/dp/B0HGBQSTDY?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [all about clean](https://lovi.care/skincare/de/p/clinique/all-about-clean/for/dry-skin) — Warning fit — [€34.50 at Amazon](https://www.amazon.de/dp/B002RBTB8C?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/de/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — [€12.59 at Amazon](https://www.amazon.de/dp/B07B65NJLV?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Smart Clinical Repair Lifting Face + Neck Cream](https://lovi.care/skincare/de/p/clinique/smart-clinical-repair-lifting-face-neck-cream/for/dry-skin) — High fit — [€48.15 at Amazon](https://www.amazon.de/dp/B0CHXGY211?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Australian Gold Botanical Lotion SPF 30](https://lovi.care/skincare/de/p/australian-gold/botanical-lotion-spf-30/for/dry-skin) — Superior fit — [€21.04 at Amazon](https://www.amazon.de/dp/B0DV9RH665?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/de/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€22.53 at Amazon](https://www.amazon.de/dp/B07D5C86RX?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/de/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/dry-skin) — Average fit — [€77.95 at Amazon](https://www.amazon.de/dp/B09FG8TJDD?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Moisture Surge Overnight Mask](https://lovi.care/skincare/de/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit — [€24.50 at Amazon](https://www.amazon.de/dp/B00HSZRQQQ?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 99% fit](https://lovi.care/skincare/de/skin/dry-skin)

### Medicube vs Clinique routines for oily skin

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/de/p/medicube/red-foam-cleanser/for/oily-skin) — High fit — [€15.60 at Amazon](https://www.amazon.de/dp/B0CVRD7N68?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/de/p/medicube/triple-collagen-toner/for/oily-skin) — High fit — [€11.64 at Amazon](https://www.amazon.de/dp/B085VS2J3T?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/de/p/medicube/age-r-booster-gel/for/oily-skin) — High fit — [€16.99 at Amazon](https://www.amazon.de/dp/B0H4MHPRLG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/de/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-skin) — Superior fit — [€32.80 at Amazon](https://www.amazon.de/dp/B0CF22FB86?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/de/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [€104.00 at Amazon](https://www.amazon.de/dp/B0DNJRC1L4?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/de/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.de/dp/B09V7Z4TJG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/de/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/de/p/medicube/zero-pore-blackhead-mud-mask/for/oily-skin) — Average fit — [€15.89 at Amazon](https://www.amazon.de/dp/B0D1G7XF9X?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [Redness Solutions Soothing Cleanser](https://lovi.care/skincare/de/p/clinique/redness-solutions-soothing-cleanser/for/oily-skin) — Average fit — [€24.77 at Amazon](https://www.amazon.de/dp/B0016LU1BK?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Some By Mi Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — [€16.59 at Amazon](https://www.amazon.de/dp/B08125WDCF?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/de/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [€24.46 at Amazon](https://www.amazon.de/dp/B003JRI3OG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/de/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-skin) — Superior fit — [€32.80 at Amazon](https://www.amazon.de/dp/B0CF22FB86?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/de/p/clinique/take-the-day-off-cleansing-balm/for/oily-skin) — Low fit — [€22.53 at Amazon](https://www.amazon.de/dp/B07D5C86RX?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Clarifying Lotion 2](https://lovi.care/skincare/de/p/clinique/clarifying-lotion-2/for/oily-skin) — Average fit — [€29.95 at Amazon](https://www.amazon.de/dp/B01N184QGF?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Even Better Clinical Dark Spot Corrector](https://lovi.care/skincare/de/p/clinique/even-better-clinical-dark-spot-corrector/for/oily-skin) — High fit — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/de/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Dr. Sebagh Deep Exfoliating Mask](https://lovi.care/skincare/de/p/dr-sebagh/deep-exfoliating-mask/for/oily-skin) — Superior fit — [€81.80 at Amazon](https://www.amazon.de/dp/B00ANF1K5Q?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 96% fit](https://lovi.care/skincare/de/skin/oily-skin)

### Medicube vs Clinique routines for combination skin

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/de/p/medicube/red-foam-cleanser/for/combination-skin) — High fit — [€15.60 at Amazon](https://www.amazon.de/dp/B0CVRD7N68?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/de/p/medicube/triple-collagen-toner/for/combination-skin) — High fit — [€11.64 at Amazon](https://www.amazon.de/dp/B085VS2J3T?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/de/p/medicube/age-r-booster-gel/for/combination-skin) — High fit — [€16.99 at Amazon](https://www.amazon.de/dp/B0H4MHPRLG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/de/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [€104.00 at Amazon](https://www.amazon.de/dp/B0DNJRC1L4?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/de/p/medicube/zero-pore-pad/for/combination-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.de/dp/B09V7Z4TJG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/de/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/de/p/medicube/zero-pore-blackhead-mud-mask/for/combination-skin) — Average fit — [€15.89 at Amazon](https://www.amazon.de/dp/B0D1G7XF9X?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [all about clean](https://lovi.care/skincare/de/p/clinique/all-about-clean/for/combination-skin) — Low fit — [€34.50 at Amazon](https://www.amazon.de/dp/B002RBTB8C?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Paula's Choice Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/de/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — [€36.00 at Amazon](https://www.amazon.de/dp/B07P7VZ2J9?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/de/p/clinique/dramatically-different-moisturizing-gel/for/combination-skin) — Average fit — [€24.46 at Amazon](https://www.amazon.de/dp/B003JRI3OG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/de/p/clinique/take-the-day-off-cleansing-balm/for/combination-skin) — Low fit — [€22.53 at Amazon](https://www.amazon.de/dp/B07D5C86RX?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Clarifying Lotion 2](https://lovi.care/skincare/de/p/clinique/clarifying-lotion-2/for/combination-skin) — Average fit — [€29.95 at Amazon](https://www.amazon.de/dp/B01N184QGF?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Even Better Clinical Dark Spot Corrector](https://lovi.care/skincare/de/p/clinique/even-better-clinical-dark-spot-corrector/for/combination-skin) — Average fit — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/de/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Origins Original Skin Retexturizing Mask with Rose Clay](https://lovi.care/skincare/de/p/origins/original-skin-retexturizing-mask-with-rose-clay/for/combination-skin) — Superior fit — [€28.50 at Amazon](https://www.amazon.de/dp/B0DV8YNCC5?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 96% fit](https://lovi.care/skincare/de/skin/combination-skin)

## Questions and answers

### Medicube or Clinique: which is better?

Medicube offers better hydration, glow, and smoothing effects for the products on this page, while Clinique stands out for gentle, fragrance-free care. Lovi rates Medicube as a Superior fit for dry skin and High for combination and acne-prone skin, compared to Average for Clinique.

### What is the difference between Medicube and Clinique?

Medicube offers superior hydration and targets anti-aging with ingredients like [niacinamide](https://lovi.care/skincare/de/ingredients/niacinamide), whereas Clinique focuses on fragrance-free, gentle skincare with ingredients like [hyaluronic acid](https://lovi.care/skincare/de/ingredients/hyaluronic-acid) and [caffeine](https://lovi.care/skincare/de/ingredients/caffeine). Lovi rates Medicube higher for dry and combination skin, while both brands match well for sensitive and oily skin.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Medicube or Clinique for dry skin?

Medicube is a better fit for dry skin, offering Superior routine fit compared to Clinique's Average fit on the products on this page. Reviewers frequently mention that Medicube products help provide deep hydration and a radiant glow.

### Medicube or Clinique: which cleanser is better?

Clinique is better for cleansers on the products on this page, as it is noted for gentle and effective cleansing. Medicube cleansers may cause irritation for sensitive skin types, whereas Clinique offers specialized options like the Redness Solutions Soothing Cleanser.

### Which is more affordable, Medicube or Clinique?

Clinique is more affordable, as pricing and value issues are commonly noted for Medicube products on this page.

### Medicube or Clinique: which brand offers better options for dry sensitive skin?

Medicube offers better routine fit options for dry sensitive skin, as Lovi rates its overall routine fit as High compared to Clinique's Average.

### Medicube or Clinique: which brand has fewer products with fragrance?

Medicube has 23 products on this page that list no fragrance and two products with fragrance, whereas every product from Clinique lists no fragrance.

### Medicube or Clinique: which brand performs better for hydration and moisture?

Medicube performs better for hydration and moisture, as it is noted for deep hydration moisturizers and gets a superior routine fit for dry skin on Lovi compared to Clinique's average fit.

### Medicube or Clinique for oily skin?

For oily skin, both Medicube and Clinique achieve a High routine fit on Lovi. Medicube features key ingredients like niacinamide, which helps reduce cutaneous pigmentation and melanosome transfer, while Clinique relies on ingredients such as caffeine for cosmetic use.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/)

### Medicube or Clinique: which moisturizer is better?

Medicube offers superior moisturizers for dry skin, as Lovi rates its routine fit as Superior compared to Clinique's Average. Niacinamide in Medicube's moisturizers helps reduce cutaneous pigmentation.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Medicube or Clinique for sensitive skin?

Both Medicube and Clinique are a High fit for sensitive skin on the products on this page. Clinique stands out for gentle and sensitive skin care.

### Medicube or Clinique for acne-prone skin?

For acne-prone skin, Lovi finds that Medicube has a High routine fit while Clinique has an Average routine fit. Reviewers mention that Medicube provides better skin texture and smoothing, whereas Clinique is noted for gentle cleansers and exfoliation.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology](https://pubmed.ncbi.nlm.nih.gov/19169201/) Squalene · Molecules, 2009
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/37377400/) Exosome cica · Journal of Cosmetic Dermatology, 2023
- [Caffeine's mechanisms of action and its cosmetic use](https://pubmed.ncbi.nlm.nih.gov/23075568/) Caffeine · Skin Pharmacology and Physiology, 2013
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Vitamin c derivatives · Experimental Dermatology, 2003
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Micro-acid complex · Journal of Dermatological Science, 2017
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Protecting skin photoaging by NF-kappaB inhibitor](https://pubmed.ncbi.nlm.nih.gov/20540695/) Magnolia officinalis bark extract · Current Drug Metabolism, 2010
- [Tea tree oil reduces histamine-induced skin inflammation](https://pubmed.ncbi.nlm.nih.gov/12452873/) Tree · The British Journal of Dermatology, 2002
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf water, Aloe barbadensis · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica flower extract · Journal of Ethnopharmacology, 2007
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/36350527/) Micro-acid complex · Dermatology and Therapy, 2023
- [Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy](https://pubmed.ncbi.nlm.nih.gov/36985709/) Polygonum cuspidatum root extract · Molecules, 2023
- [Role of Resveratrol in Regulating Cutaneous Functions](https://pubmed.ncbi.nlm.nih.gov/32382280/) Polygonum cuspidatum root extract · Evidence-based Complementary and Alternative Medicine, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [Protective effects of Camellia japonica flower extract against urban air pollutants](https://pubmed.ncbi.nlm.nih.gov/30691451/) Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28341613/) Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB](https://pubmed.ncbi.nlm.nih.gov/17346696/) Magnolia officinalis bark extract · European Journal of Pharmacology, 2007
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen extract · Nutrients, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Vitamin c derivatives · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel extract · Phytochemistry, 2001
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract, Madecassoside, Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results](https://pubmed.ncbi.nlm.nih.gov/39810881/) Probiotic technology · Journal of Experimental Pharmacology, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid, Micro-acid complex · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine](https://pubmed.ncbi.nlm.nih.gov/34284096/) Sophora angustifolia root extract, Sophora flavescens root extract · European Journal of Pharmaceutical Sciences, 2021
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis flower extract · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex](https://pubmed.ncbi.nlm.nih.gov/39205505/) Succinic acid · Journal of Cosmetic Dermatology, 2024
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane](https://pubmed.ncbi.nlm.nih.gov/22247236/) Cyclopentasiloxane · International Journal of Toxicology, 2011
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Understanding Solar Skin Elastosis-Cause and Treatment](https://pubmed.ncbi.nlm.nih.gov/30052192/) Witch hazel extract · Journal of Cosmetic Science, 2018
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract](https://pubmed.ncbi.nlm.nih.gov/33410284/) Camellia japonica flower extract · FEBS Open Bio, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota](https://pubmed.ncbi.nlm.nih.gov/39598779/) Camellia sinensis leaf extract · Molecules, 2024
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial](https://pubmed.ncbi.nlm.nih.gov/37726676/) Portulaca oleracea extract · BMC Oral Health, 2023
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed extract · Skin Pharmacology and Physiology, 2007
- [Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract](https://pubmed.ncbi.nlm.nih.gov/35403355/) Grape seed extract · Journal of Cosmetic Dermatology, 2022
- [Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles](https://pubmed.ncbi.nlm.nih.gov/32783330/) Dimethoxytolyl propylresorcinol · Journal of Cosmetic Dermatology, 2021
- [Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits](https://pubmed.ncbi.nlm.nih.gov/20618556/) Multi-peptides · Journal of Cosmetic Dermatology, 2010
- [Algae extract protection effect on oxidized protein level in human stratum corneum](https://pubmed.ncbi.nlm.nih.gov/15247018/) Algae extract · Annals of the New York Academy of Sciences, 2004
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate](https://pubmed.ncbi.nlm.nih.gov/21772026/) Sesamum indicum oil · International Journal of Toxicology, 2011
- [Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol](https://pubmed.ncbi.nlm.nih.gov/19514921/) Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Composition characterization and clinical efficacy study of a salmon egg extract](https://pubmed.ncbi.nlm.nih.gov/23738607/) Salmon egg extract · International Journal of Cosmetic Science, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations](https://pubmed.ncbi.nlm.nih.gov/31435711/) Ethanolamine · Archives of Toxicology, 2019
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride, Capric triglyceride · Life, 2023
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
- [Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome](https://pubmed.ncbi.nlm.nih.gov/37767337/) Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022
- [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) Sodium dna, Pdrn polydeoxyribonucleotide · International Journal of Molecular Sciences, 2025
- [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) Sodium dna · International Journal of Biological Macromolecules, 2025
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- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers](https://pubmed.ncbi.nlm.nih.gov/38771104/) Dimethicone · Military Medicine, 2024
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- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies](https://pubmed.ncbi.nlm.nih.gov/41668671/) Laminaria digitata extract · International Journal of Cosmetic Science, 2026
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- [Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients](https://pubmed.ncbi.nlm.nih.gov/42698229/) Lactobacillus ferment · International Journal of Cosmetic Science, 2026

## The brands

- Korean skincare: [Medicube](https://lovi.care/skincare/de/brands/medicube)
- American skincare: [Clinique](https://lovi.care/skincare/de/brands/clinique)

## More comparisons

- [SKIN1004 vs Medicube](https://lovi.care/skincare/de/compare/skin1004-vs-medicube)
- [SKIN1004 vs Clinique](https://lovi.care/skincare/de/compare/skin1004-vs-clinique)
- [Anua vs Medicube](https://lovi.care/skincare/de/compare/anua-vs-medicube)
- [Anua vs Clinique](https://lovi.care/skincare/de/compare/anua-vs-clinique)
- [Medicube vs The Ordinary](https://lovi.care/skincare/de/compare/medicube-vs-the-ordinary)
- [Medicube vs Beauty of Joseon](https://lovi.care/skincare/de/compare/medicube-vs-beauty-of-joseon)
- [Medicube vs COSRX](https://lovi.care/skincare/de/compare/medicube-vs-cosrx)
- [Medicube vs CeraVe](https://lovi.care/skincare/de/compare/medicube-vs-cerave)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/de/compare/medicube-vs-la-roche-posay)
- [Medicube vs Dr. Althea](https://lovi.care/skincare/de/compare/medicube-vs-dr-althea)
- [Medicube vs Some By Mi](https://lovi.care/skincare/de/compare/medicube-vs-some-by-mi)
- [Medicube vs Torriden](https://lovi.care/skincare/de/compare/medicube-vs-torriden)
- [Medicube vs celimax](https://lovi.care/skincare/de/compare/medicube-vs-celimax)
- [Medicube vs Purito](https://lovi.care/skincare/de/compare/medicube-vs-purito)
- [Medicube vs Cetaphil](https://lovi.care/skincare/de/compare/medicube-vs-cetaphil)
- [Medicube vs Paula's Choice](https://lovi.care/skincare/de/compare/medicube-vs-paula-s-choice)
- [Medicube vs Neutrogena](https://lovi.care/skincare/de/compare/medicube-vs-neutrogena)
- [Medicube vs Kiehl's](https://lovi.care/skincare/de/compare/medicube-vs-kiehl-s)
- [Medicube vs Caudalie](https://lovi.care/skincare/de/compare/medicube-vs-caudalie)
- [Medicube vs Dermalogica](https://lovi.care/skincare/de/compare/medicube-vs-dermalogica)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medicube-vs-clinique
- United Kingdom: https://lovi.care/skincare/uk/compare/medicube-vs-clinique
- Ireland: https://lovi.care/skincare/ie/compare/medicube-vs-clinique
- Germany: https://lovi.care/skincare/de/compare/medicube-vs-clinique (this page)
- France: https://lovi.care/skincare/fr/compare/medicube-vs-clinique
- Italy: https://lovi.care/skincare/it/compare/medicube-vs-clinique
- Netherlands: https://lovi.care/skincare/nl/compare/medicube-vs-clinique
- Spain: https://lovi.care/skincare/es/compare/medicube-vs-clinique
- Canada: https://lovi.care/skincare/ca/compare/medicube-vs-clinique
- Australia: https://lovi.care/skincare/au/compare/medicube-vs-clinique
- Singapore: https://lovi.care/skincare/sg/compare/medicube-vs-clinique
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medicube-vs-clinique
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medicube-vs-clinique