# Hada Labo vs Natura Bissé

Page: https://lovi.care/skincare/de/compare/hada-labo-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Hada Labo and Natura Bissé are distinct skincare brands founded in Japan and Spain, respectively. The Japanese line is celebrated for its hydrating toners, gentle makeup removers, and nourishing moisturizers driven by advanced science, while the Spanish house is beloved for its luxurious moisturizers and advanced formulas. The former suits dry skin and acne-prone skin best with standout options like the Gokujyun Lotion, Shirojyun Premium Whitening Lotion, and Gokujun Premium, whereas the latter suits mature, dry, and sensitive skin best with the Diamond Extreme for acne-prone skin. Ultimately, both offer carefully crafted treatments designed to restore balance, vitality, and essential hydration to the complexion.

Hada Labo is a Japanese skincare brand founded in 2004 and owned by Rohto Pharmaceutical Co., Ltd..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Hada_Labo) [hadalabosa.co.za](https://hadalabosa.co.za/about-hada-labo/) [hadalabotokyo.pl](https://www.hadalabotokyo.pl/en/the-world-of-hada-labo/brand-history/)

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular Hada Labo and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pge53262ae96).

### Popular Hada Labo vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/de/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [€266.00 at Amazon](https://www.amazon.de/dp/B0BKLRMKZV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### Hada Labo

- [Gokujyun Lotion](https://lovi.care/skincare/de/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit — [€25.57 at Amazon](https://www.amazon.de/dp/B09C7LPC7M?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Gokujun Premium](https://lovi.care/skincare/de/p/hada-labo/gokujun-premium/for/dry-skin) — Superior fit
- [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/de/p/hada-labo/shirojyun-premium-whitening-lotion/for/dry-skin) — High fit — [€19.95 at Amazon](https://www.amazon.de/dp/B08WSCPL38?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Gokujyun Cleansing Oil](https://lovi.care/skincare/de/p/hada-labo/gokujyun-cleansing-oil/for/dry-skin) — Superior fit
- [Gokujyun Perfect Gel](https://lovi.care/skincare/de/p/hada-labo/gokujyun-perfect-gel/for/dry-skin) — High fit
- [Premium Whitening Lotion (Light)](https://lovi.care/skincare/de/p/hada-labo/premium-whitening-lotion-light/for/dry-sensitive-skin) — High fit — [€19.95 at Amazon](https://www.amazon.de/dp/B08WSCPL38?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Hada Labo or Natura Bissé: which is better?

Hada Labo is a better fit for dry skin, offering Superior Lovi ratings across multiple products, whereas Natura Bissé offers a luxury option that is less versatile for everyday hydration. [Hyaluronic acid](https://lovi.care/skincare/de/ingredients/hyaluronic-acid) helps provide deep moisture to improve skin quality.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Hada Labo and Natura Bissé?

Hada Labo is a Japanese brand founded in 2004 that focuses on fragrance-free hyaluronic acid products with superior to high fits for dry and mature skin, whereas Natura Bissé is a Spanish luxury brand founded in 1979 offering items like the Diamond Extreme moisturizer which includes fragrance.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Hada Labo or Natura Bissé: which moisturizer is better?

For dry skin, Hada Labo Gokujyun Perfect Gel has a High Lovi fit while Natura Bissé Diamond Extreme also has a High fit, but Hada Labo offers fragrance-free hydration.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Hada Labo or Natura Bissé?

Hada Labo is more affordable than Natura Bissé, as the products on this page offer value and versatility.

### Which causes fewer breakouts, Hada Labo or Natura Bissé?

Hada Labo has products on this page with High to Average fit levels for acne-prone skin, while Natura Bissé has a Diamond Extreme moisturizer with an Average fit level for acne-prone skin. However, reviewer feedback for Hada Labo mentions breakouts and clogged pores as a negative.

### Between Hada Labo and Natura Bissé, which brand offers fragrance-free products according to the page?

Hada Labo offers fragrance-free products, as every product on this page for the brand lists no fragrance in its ingredients, whereas Natura Bissé includes fragrance in its products.

### How do the founding years and countries of origin compare between Hada Labo and Natura Bissé?

Hada Labo was founded in 2004 in Japan, whereas Natura Bissé was founded in 1979 in Spain.

### Which brand has products specifically rated as having a Superior Lovi fit level for dry skin?

Hada Labo has products specifically rated as having a Superior Lovi fit level for dry skin, such as the Gokujyun Lotion and Gokujyun Cleansing Oil. Natura Bissé also features a product with a High fit level for dry skin.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [Preparation and characterization of a lecithin nanoemulsion as a topical delivery system](https://pubmed.ncbi.nlm.nih.gov/20652152/) Hydroxylated lecithin · Nanoscale Research Letters, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [The anti-wrinkles properties of sodium acetylated hyaluronate](https://pubmed.ncbi.nlm.nih.gov/34708918/) Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides](https://pubmed.ncbi.nlm.nih.gov/36613524/) Glucosyl ceramide · International Journal of Molecular Sciences, 2022
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging](https://pubmed.ncbi.nlm.nih.gov/42728863/) Sodium acetylhyaluronate · Skin Research and Technology, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- Japanese skincare: [Hada Labo](https://lovi.care/skincare/de/brands/hada-labo)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/de/brands/natura-bisse)

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- [Some By Mi vs Hada Labo](https://lovi.care/skincare/de/compare/some-by-mi-vs-hada-labo)
- [Some By Mi vs Natura Bissé](https://lovi.care/skincare/de/compare/some-by-mi-vs-natura-bisse)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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