# Yepoda vs Sesderma

Page: https://lovi.care/skincare/compare/yepoda-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Yepoda and Sesderma are distinguished skincare brands that offer thoughtfully crafted daily care and advanced dermatological solutions, respectively. Yepoda, a German brand founded in 2020, is known for its gentle cleansers and [serums](https://lovi.care/skincare/ingredients/serum) featuring key ingredients that suit individuals seeking soothing daily care. Conversely, Sesderma is a Spanish brand founded in 1989 that is celebrated for its meticulously engineered formulas, including advanced serums like the Azelac RU Serum designed for sensitive, hyperpigmented, and aging skin types. While both brands rely on carefully composed formulas to address specific concerns, they differ notably in their origins, standout products, and targeted skin types.

Yepoda is a German skincare brand founded in 2020 and owned by Verlinvest since 2026.

[yepoda.com](https://yepoda.com/pages/about) [tracxn.com](https://tracxn.com/d/companies/yepoda/__zVJ6RscQbX9zMN6JdHEEXGjupBf5FkdIoMrg1_8-sQ8) [koreaherald.com](https://www.koreaherald.com/article/10762796) [eu.yepoda.com](https://eu.yepoda.com/pages/imprint-legal-disclosure)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Yepoda and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg8a125b1fdd).

### Popular Yepoda vs Sesderma products

#### Yepoda

- [The Bubble Double](https://lovi.care/skincare/p/yepoda/the-bubble-double/for/oily-acne-prone-skin) — High fit — [$23.00 at Amazon](https://www.amazon.com/dp/B08RC6CJ32?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The Repair Hero](https://lovi.care/skincare/p/yepoda/the-repair-hero/for/acne-prone-skin) — Superior fit — [$28.00 at Amazon](https://www.amazon.com/dp/B0971LQMQ9?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [$60.00 at Amazon](https://www.amazon.com/dp/B00987RKWW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Yepoda or Sesderma: which is better?

Yepoda is a better choice than Sesderma if you want fragrance-free options, as every product on Yepoda's page lists no fragrance. For acne-prone skin, Yepoda achieves a Superior fit level with The Repair Hero [serum](https://lovi.care/skincare/ingredients/serum), while Sesderma's Azelac RU Serum reaches a High fit level.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### What is the difference between Yepoda and Sesderma?

Yepoda has a High Lovi fit for oily acne-prone skin with The Bubble Double cleanser and offers fragrance-free formulas across the products on this page. Sesderma includes fragrance in its Azelac RU Serum, which has an Average Lovi fit for oily acne-prone skin.

### Which is more affordable, Yepoda or Sesderma?

The provided page facts do not contain pricing information for either Yepoda or Sesderma, so it is not possible to determine which brand is more affordable.

### Which causes fewer breakouts, Yepoda or Sesderma?

Yepoda offers better options for acne-prone skin on this page, achieving a Superior Lovi fit for The Repair Hero serum compared to the High fit of Sesderma's Azelac RU Serum. Additionally, every Yepoda product on this page is formulated without fragrance, which helps reduce the risk of irritation that can lead to breakouts.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which brand is older, Yepoda or Sesderma, and where were they founded?

Sesderma is the older brand, having been founded in Spain in 1989, while Yepoda was founded later in Germany in 2020.

### Do products from Yepoda or Sesderma contain fragrance?

Yepoda features no fragrance across the products on this page, while Sesderma includes fragrance in its Azelac RU Serum.

### How does the Lovi fit level for dry skin compare between The Repair Hero by Yepoda and Azelac RU Serum by Sesderma?

Yepoda's The Repair Hero has a High Lovi fit level for dry skin, whereas Sesderma's Azelac RU Serum has a Low fit level.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Sodium hyaluronate · Drug Delivery, 2017
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Fermented pomegranate extracts protect against oxidative stress and aging of skin](https://pubmed.ncbi.nlm.nih.gov/34416060/) Punica granatum fruit extract · Journal of Cosmetic Dermatology, 2022
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro](https://pubmed.ncbi.nlm.nih.gov/37218728/) Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects](https://pubmed.ncbi.nlm.nih.gov/25610348/) Punica granatum extract · Postepy Dermatologii I Alergologii, 2014
- [Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin](https://pubmed.ncbi.nlm.nih.gov/16847171/) Copper tripeptide-1 · Archives of Facial Plastic Surgery, 2006
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights](https://pubmed.ncbi.nlm.nih.gov/40755496/) Punica granatum extract · Food Science & Nutrition, 2025
- [Poly-γ-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model](https://pubmed.ncbi.nlm.nih.gov/39940752/) Polyglutamic acid · International Journal of Molecular Sciences, 2025
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu](https://pubmed.ncbi.nlm.nih.gov/42573538/) Copper tripeptide-1 · Skin Research and Technology, 2026

## The brands

- German skincare: [Yepoda](https://lovi.care/skincare/brands/yepoda)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/brands/sesderma)

## More comparisons

- [SKIN1004 vs Yepoda](https://lovi.care/skincare/compare/skin1004-vs-yepoda)
- [SKIN1004 vs Sesderma](https://lovi.care/skincare/compare/skin1004-vs-sesderma)
- [Anua vs Yepoda](https://lovi.care/skincare/compare/anua-vs-yepoda)
- [Anua vs Sesderma](https://lovi.care/skincare/compare/anua-vs-sesderma)
- [Medicube vs Yepoda](https://lovi.care/skincare/compare/medicube-vs-yepoda)
- [Medicube vs Sesderma](https://lovi.care/skincare/compare/medicube-vs-sesderma)
- [The Ordinary vs Yepoda](https://lovi.care/skincare/compare/the-ordinary-vs-yepoda)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/compare/the-ordinary-vs-sesderma)
- [Beauty of Joseon vs Yepoda](https://lovi.care/skincare/compare/beauty-of-joseon-vs-yepoda)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/compare/beauty-of-joseon-vs-sesderma)
- [COSRX vs Yepoda](https://lovi.care/skincare/compare/cosrx-vs-yepoda)
- [COSRX vs Sesderma](https://lovi.care/skincare/compare/cosrx-vs-sesderma)
- [CeraVe vs Yepoda](https://lovi.care/skincare/compare/cerave-vs-yepoda)
- [CeraVe vs Sesderma](https://lovi.care/skincare/compare/cerave-vs-sesderma)
- [La Roche-Posay vs Yepoda](https://lovi.care/skincare/compare/la-roche-posay-vs-yepoda)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/compare/la-roche-posay-vs-sesderma)
- [Dr. Althea vs Yepoda](https://lovi.care/skincare/compare/dr-althea-vs-yepoda)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/compare/dr-althea-vs-sesderma)
- [Some By Mi vs Yepoda](https://lovi.care/skincare/compare/some-by-mi-vs-yepoda)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/compare/some-by-mi-vs-sesderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/yepoda-vs-sesderma (this page)
- United Kingdom: https://lovi.care/skincare/uk/compare/yepoda-vs-sesderma
- Ireland: https://lovi.care/skincare/ie/compare/yepoda-vs-sesderma
- Germany: https://lovi.care/skincare/de/compare/yepoda-vs-sesderma
- France: https://lovi.care/skincare/fr/compare/yepoda-vs-sesderma
- Italy: https://lovi.care/skincare/it/compare/yepoda-vs-sesderma
- Netherlands: https://lovi.care/skincare/nl/compare/yepoda-vs-sesderma
- Spain: https://lovi.care/skincare/es/compare/yepoda-vs-sesderma
- Canada: https://lovi.care/skincare/ca/compare/yepoda-vs-sesderma
- Australia: https://lovi.care/skincare/au/compare/yepoda-vs-sesderma
- Singapore: https://lovi.care/skincare/sg/compare/yepoda-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/yepoda-vs-sesderma
- United Arab Emirates: https://lovi.care/skincare/ae/compare/yepoda-vs-sesderma