# Sesderma vs OPTASE

Page: https://lovi.care/skincare/compare/sesderma-vs-optase

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Sesderma and OPTASE are respected skincare lines designed to address diverse dermatological needs. Sesderma is known for its advanced [serums](https://lovi.care/skincare/ingredients/serum) and meticulously engineered formulas utilizing botanical [extracts](https://lovi.care/skincare/ingredients/extract) and active compounds, suiting sensitive, hyperpigmented, and aging skin types best with standout products like the Azelac RU Serum for acne-prone skin. Meanwhile, the brand is beloved for gentle makeup removers and carefully balanced formulas that suit sensitive, dry, and irritated skin best, offering soothing and restorative qualities through reliable options such as the LIFE SENSITIVE EYE MAKEUP REMOVER for acne-prone skin. While both support calm daily routines, they differ as the former refines skin texture and promotes radiance, whereas the latter consistently supports comfortable care.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and OPTASE products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg296048eeb9).

### Popular Sesderma vs OPTASE products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [$60.00 at Amazon](https://www.amazon.com/dp/B00987RKWW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### OPTASE

- [LIFE SENSITIVE EYE MAKEUP REMOVER](https://lovi.care/skincare/p/optase/life-sensitive-eye-makeup-remover/for/sensitive-skin) — High fit

## Questions and answers

### Sesderma or OPTASE: which is better?

Neither brand is universally better, as Sesderma earns a High Lovi fit for acne-prone skin and dark spots with its Azelac RU [Serum](https://lovi.care/skincare/ingredients/serum), while OPTASE earns a High Lovi fit for sensitive skin with its LIFE SENSITIVE EYE MAKEUP REMOVER. Shoppers should note that the Azelac RU Serum contains fragrance, whereas the products on this page from OPTASE are fragrance-free.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### What is the difference between Sesderma and OPTASE?

Sesderma offers the Azelac RU Serum, which has a High Lovi fit for acne-prone skin, combination skin, and skin with dark spots, though it contains fragrance. OPTASE offers the LIFE SENSITIVE EYE MAKEUP REMOVER, which achieves a High Lovi fit for sensitive skin and contains no fragrance across the products on this page.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which is more affordable, Sesderma or OPTASE?

The products on this page for both Sesderma and OPTASE do not list pricing details, so neither brand can be called more affordable than the other.

### Which causes fewer breakouts, Sesderma or OPTASE?

For acne-prone skin, Sesderma has a High Lovi fit with its Azelac RU Serum, while OPTASE has an Average fit with its LIFE SENSITIVE EYE MAKEUP REMOVER. [Azelaic acid](https://lovi.care/skincare/ingredients/azelaic-acid) helps reduce acne-prone skin symptoms.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which brand was founded earlier, Sesderma or OPTASE?

Sesderma was founded earlier than OPTASE, having started in Spain in 1989 while OPTASE was founded in 2016.

### Do both Sesderma and OPTASE products contain fragrance?

Sesderma includes fragrance in its products on this page, whereas OPTASE features no fragrance across its items.

### Which brand offers a serum for skin with dark spots?

Sesderma offers a serum for skin with dark spots through its Azelac RU Serum, which Lovi rates as a High fit for skin with dark spots. OPTASE does not offer a serum on this page.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Vitamin b5 · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Vitamin b5 · The Journal of Dermatological Treatment, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Vitamin b5 · Journal of Cosmetic Dermatology, 2025
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Investigating the Effects of a Manuka Honey, Royal Jelly, and Bee Venom-Derived Face Serum on Skin Health and Signs of Aging](https://pubmed.ncbi.nlm.nih.gov/40291268/) Manuka honey · Cureus, 2025

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/brands/sesderma)
- Skincare: [OPTASE](https://lovi.care/skincare/brands/optase)

## More comparisons

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- [SKIN1004 vs OPTASE](https://lovi.care/skincare/compare/skin1004-vs-optase)
- [Anua vs Sesderma](https://lovi.care/skincare/compare/anua-vs-sesderma)
- [Anua vs OPTASE](https://lovi.care/skincare/compare/anua-vs-optase)
- [Medicube vs Sesderma](https://lovi.care/skincare/compare/medicube-vs-sesderma)
- [Medicube vs OPTASE](https://lovi.care/skincare/compare/medicube-vs-optase)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs OPTASE](https://lovi.care/skincare/compare/the-ordinary-vs-optase)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/compare/beauty-of-joseon-vs-sesderma)
- [Beauty of Joseon vs OPTASE](https://lovi.care/skincare/compare/beauty-of-joseon-vs-optase)
- [COSRX vs Sesderma](https://lovi.care/skincare/compare/cosrx-vs-sesderma)
- [COSRX vs OPTASE](https://lovi.care/skincare/compare/cosrx-vs-optase)
- [CeraVe vs Sesderma](https://lovi.care/skincare/compare/cerave-vs-sesderma)
- [CeraVe vs OPTASE](https://lovi.care/skincare/compare/cerave-vs-optase)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs OPTASE](https://lovi.care/skincare/compare/la-roche-posay-vs-optase)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs OPTASE](https://lovi.care/skincare/compare/dr-althea-vs-optase)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs OPTASE](https://lovi.care/skincare/compare/some-by-mi-vs-optase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-optase (this page)
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