# Sesderma vs ISDIN Isdinceutics

Page: https://lovi.care/skincare/compare/sesderma-vs-isdin-isdinceutics

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Sesderma and ISDIN Isdinceutics are two established Spanish skincare brands founded in 1989 and 1975, respectively. The first brand is beloved for advanced [serums](https://lovi.care/skincare/ingredients/serum) like the Azelac RU Serum, while the second brand is revered for targeted eye products such as K-Ox Eyes. Both options feature meticulously engineered formulas, with the first brand suiting sensitive, hyperpigmented, and aging skin best, and the second brand suiting mature, dry, and sensitive skin best. They differ primarily in their standout formulations, botanical [extracts](https://lovi.care/skincare/ingredients/extract), and active compounds that address specific concerns like dark circles, puffiness, and acne-prone skin.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

ISDIN Isdinceutics is a Spanish skincare brand founded in 1975 and owned by Puig since 2027.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/)

This page compares some of the most popular Sesderma and ISDIN Isdinceutics products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg5c47f7313e).

### Popular Sesderma vs ISDIN Isdinceutics products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [$60.00 at Amazon](https://www.amazon.com/dp/B00987RKWW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### ISDIN Isdinceutics

- [K-Ox Eyes](https://lovi.care/skincare/p/isdin-isdinceutics/k-ox-eyes/for/dry-skin) — High fit

## Questions and answers

### Sesderma or ISDIN Isdinceutics: which is better?

Neither brand is universally better, as they offer different products for different concerns on this page. For acne-prone and dark spots, Sesderma's Azelac RU [Serum](https://lovi.care/skincare/ingredients/serum) has a High Lovi fit, while ISDIN Isdinceutics' K-Ox Eyes achieves a High Lovi fit for mature and sensitive skin.

### What is the difference between Sesderma and ISDIN Isdinceutics?

Sesderma and ISDIN Isdinceutics are both Spanish skincare brands founded decades ago, but they offer entirely different products on this page for specific concerns. Sesderma features Azelac RU Serum, which achieves a High Lovi fit for acne-prone skin and dark spots, while ISDIN Isdinceutics offers K-Ox Eyes, which has a High Lovi fit for dry, sensitive, and mature skin. Both products on this page contain fragrance.

### Which is more affordable, Sesderma or ISDIN Isdinceutics?

The page facts do not mention the prices of Sesderma and ISDIN Isdinceutics, so it is not possible to compare which brand is more affordable.

### Which causes fewer breakouts, Sesderma or ISDIN Isdinceutics?

For acne-prone skin, Sesderma has a High Lovi fit with its Azelac RU Serum, while ISDIN Isdinceutics has an Average fit with K-Ox Eyes.

### When were Sesderma and ISDIN Isdinceutics founded and in which country?

Sesderma was founded in 1989 in Spain, while ISDIN Isdinceutics was founded in 1975 in Spain.

### Which company owns Sesderma and who is the parent company of ISDIN Isdinceutics?

Sesderma is owned by Grupo Sesderma, and ISDIN Isdinceutics is owned by Puig.

### Do the products from Sesderma and ISDIN Isdinceutics listed on this page contain fragrance?

Yes, both the products on this page from Sesderma and ISDIN Isdinceutics contain fragrance. Specifically, the Azelac RU Serum and K-Ox Eyes both list fragrance.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage](https://pubmed.ncbi.nlm.nih.gov/21699266/) Chrysin · Journal of Agricultural and Food Chemistry, 2011
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation](https://pubmed.ncbi.nlm.nih.gov/19566395/) Ascorbyl palmitate · Journal of Microencapsulation, 2010
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/brands/sesderma)
- Spanish skincare: [ISDIN Isdinceutics](https://lovi.care/skincare/brands/isdin-isdinceutics)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-isdin-isdinceutics (this page)
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-isdin-isdinceutics
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-isdin-isdinceutics
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-isdin-isdinceutics
- France: https://lovi.care/skincare/fr/compare/sesderma-vs-isdin-isdinceutics
- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-isdin-isdinceutics
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-isdin-isdinceutics
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-isdin-isdinceutics
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-isdin-isdinceutics
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-isdin-isdinceutics
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-isdin-isdinceutics
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-isdin-isdinceutics
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-isdin-isdinceutics