# Rilastil vs Natura Bissé

Page: https://lovi.care/skincare/compare/rilastil-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Rilastil and Natura Bissé are esteemed skincare lines known for their meticulous formulas and advanced treatments. The former offers targeted [serums](https://lovi.care/skincare/ingredients/serum) featuring gentle, nourishing ingredients, while the latter is celebrated for luxurious moisturizers and rich properties. Both suit sensitive, dry, and mature skin best, though they differ through Rilastil focusing on daily comfort and Natura Bissé restoring vitality.

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular Rilastil and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgd84659ad7a).

### Popular Rilastil vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [$420.00 at Amazon](https://www.amazon.com/dp/B0BKLRMKZV?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### Rilastil

- [Acnestil](https://lovi.care/skincare/p/rilastil/acnestil/for/oily-skin) — Average fit

## Questions and answers

### Rilastil or Natura Bissé: which is better?

Natura Bissé offers superior fit for mature skin with its Diamond Extreme moisturizer, while Rilastil provides average fit across multiple acne and skin-spot types with its Acnestil [serum](https://lovi.care/skincare/ingredients/serum). Furthermore, every Rilastil product on this page lists no fragrance, whereas Natura Bissé includes fragrance in its moisturizer.

### What is the difference between Rilastil and Natura Bissé?

For mature skin, Natura Bissé has a Superior Lovi fit, whereas Rilastil has a Low fit. Additionally, every Rilastil product on this page lists no fragrance, while Natura Bissé includes fragrance in Diamond Extreme.

### Which is more affordable, Rilastil or Natura Bissé?

I am sorry, but the provided page facts do not contain pricing or affordability information to compare Rilastil and Natura Bissé.

### Which causes fewer breakouts, Rilastil or Natura Bissé?

Both Rilastil's Acnestil serum and Natura Bisse's Diamond Extreme moisturizer get an Average Lovi fit for acne-prone skin, meaning neither is a standout choice for preventing breakouts over the other. The products on this page from Rilastil list no fragrance, while Natura Bisse's Diamond Extreme includes fragrance, which may affect sensitive skin types differently.

### Which brand was founded earlier, Rilastil or Natura Bissé?

Rilastil was founded earlier, in 1972, whereas Natura Bissé was founded in 1979 in Spain.

### Which brand includes fragrance in its Diamond Extreme product while Rilastil has no fragrance across its products?

Natura Bissé includes fragrance in its Diamond Extreme product, whereas every product on this page from Rilastil lists no fragrance.

### Which company owns Rilastil and which owns Natura Bissé?

Rilastil is owned by Istituto Ganassini, while Natura Bissé is owned by Natura Bissé International, S.A.

## Research behind their key ingredients

- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda](https://pubmed.ncbi.nlm.nih.gov/35388606/) Mandelic acid · Journal of Cosmetic Dermatology, 2022
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- Skincare: [Rilastil](https://lovi.care/skincare/brands/rilastil)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/brands/natura-bisse)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/rilastil-vs-natura-bisse (this page)
- United Kingdom: https://lovi.care/skincare/uk/compare/rilastil-vs-natura-bisse
- Ireland: https://lovi.care/skincare/ie/compare/rilastil-vs-natura-bisse
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