# Medicube vs SK-II

Page: https://lovi.care/skincare/compare/medicube-vs-sk-ii

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Medicube and SK-II are esteemed skincare lines from Korea and Japan, respectively, offering thoughtfully formulated moisturizers, [serums](https://lovi.care/skincare/ingredients/serum), toners, and masks. The Korean brand harnesses [niacinamide](https://lovi.care/skincare/ingredients/niacinamide), [collagen](https://lovi.care/skincare/ingredients/collagen), and [hyaluronic acid](https://lovi.care/skincare/ingredients/hyaluronic-acid), while the Japanese brand is anchored by its signature ingredient, pitera. Both suit dry skin and acne-prone skin best to balance hydration and clarity. While the first relies on science-backed peptides and gels, the second leverages its [proprietary ferment](https://lovi.care/skincare/ingredients/proprietary) to refine pores and texture.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

[medicubereviews.co.uk](https://medicubereviews.co.uk/medicube/story/) [glossy.co](https://www.glossy.co/beauty/medicubes-founder-on-the-products-and-people-that-fueled-the-k-beauty-brands-booming-year/)

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

[en.wikipedia.org](https://en.wikipedia.org/wiki/SK-II) [discoversk-ii.wixsite.com](https://discoversk-ii.wixsite.com/home/brand-history) [glossy.co](https://www.glossy.co/beauty/despite-strong-results-in-beauty-in-the-first-quarter-pg-will-eliminate-thousands-of-jobs/)

This page compares some of the most popular Medicube and SK-II products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgb5438cb502).

### Popular Medicube vs SK-II products

#### SK-II

- [Facial Treatment Essence](https://lovi.care/skincare/p/sk-ii/facial-treatment-essence/for/dry-skin) — High fit — [$99.00 at Amazon](https://www.amazon.com/dp/B000H723LU?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Facial Treatment Mask](https://lovi.care/skincare/p/sk-ii/facial-treatment-mask/for/dry-skin) — High fit — [$100.00 at Amazon](https://www.amazon.com/dp/B078MQP5ZF?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Facial Treatment Clear Lotion](https://lovi.care/skincare/p/sk-ii/facial-treatment-clear-lotion/for/oily-skin) — High fit — [$80.00 at Amazon](https://www.amazon.com/dp/B072C3MCDH?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Skinpower Advanced Cream](https://lovi.care/skincare/p/sk-ii/skinpower-advanced-cream/for/mature-skin) — High fit — [$255.00 at Amazon](https://www.amazon.com/dp/B0GMLY2Z6D?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Genoptics Ultraura Essence](https://lovi.care/skincare/p/sk-ii/genoptics-ultraura-essence/for/acne-prone-skin) — Superior fit — [$265.00 at Amazon](https://www.amazon.com/dp/B0CVR58C7P?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Facial Treatment Cleansing Oil](https://lovi.care/skincare/p/sk-ii/facial-treatment-cleansing-oil/for/dry-skin) — High fit — [$75.00 at Amazon](https://www.amazon.com/dp/B084M1R6RH?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Genoptics Spot Essence](https://lovi.care/skincare/p/sk-ii/genoptics-spot-essence/for/dark-spots) — Average fit

#### Medicube

- [Zero Pore Pad](https://lovi.care/skincare/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [$18.90 at Amazon](https://www.amazon.com/dp/B09V7Z4TJG?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [PDRN Pink Peptide Serum](https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [$18.90 at Amazon](https://www.amazon.com/dp/B0DBF65JYY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Collagen Jelly Cream](https://lovi.care/skincare/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [$14.90 at Amazon](https://www.amazon.com/dp/B0DGPSZVW3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Collagen Night Wrapping Mask](https://lovi.care/skincare/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit — [$19.00 at Amazon](https://www.amazon.com/dp/B0BRMYHMS5?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [PDRN Pink Collagen Gel Mask](https://lovi.care/skincare/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin) — High fit — [$21.80 at Amazon](https://www.amazon.com/dp/B0GY4RQGFY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [DEEP VITA-C CAPSULE CREAM](https://lovi.care/skincare/p/medicube/deep-vita-c-capsule-cream/for/sensitive-skin) — Average fit — [$19.90 at Amazon](https://www.amazon.com/dp/B0D2Z3GGCY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [TRIPLE COLLAGEN CREAM](https://lovi.care/skincare/p/medicube/triple-collagen-cream/for/mature-skin) — Average fit — [$19.90 at Amazon](https://www.amazon.com/dp/B0BPXT3GBN?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Zero Foam Cleanser](https://lovi.care/skincare/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [$29.33 at Amazon](https://www.amazon.com/dp/B0GF8DLCRW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## People Say

Medicube

SK-II

- Hydration and Moisture Mostly Mentioned Mostly Mentioned “skin feels bouncier and hydrated — Medicube PDRN Pink Peptide Serum” “glass skin — Medicube PDRN Pink Collagen Gel Mask” “flooded my skin with moisture — SK-II Facial Treatment Mask” “skin feels deeply hydrated, plump, and smoother — SK-II Skinpower Advanced Cream”
- Packaging, Convenience and Lather Mostly Mentioned Often Mentioned “Mochi-like foam — Medicube Zero Foam Cleanser” “feels amazing and cooling — Medicube Zero Pore Blackhead Mud Mask” “dries super fast — Medicube Zero Pore Blackhead Mud Mask” “Removes leftover dirt — SK-II Facial Treatment Clear Lotion”
- Skin Texture Improvement Often Mentioned Often Mentioned “gives my skin a smooth, glass-like finish — Medicube Zero Pore Pad” “skin feels smoother — Medicube PDRN Pink Peptide Serum” “skin feels soft as butter — SK-II Facial Treatment Essence” “pores became miraculously invisible — SK-II Facial Treatment Mask”
- Radiance and Glow Often Mentioned Often Mentioned “gave me instant glass skin — Medicube Collagen Jelly Cream” “woke up with glowing skin — Medicube Collagen Night Wrapping Mask” “gives a glass skin look — SK-II Facial Treatment Essence” “leaves me with a red carpet glow — SK-II Facial Treatment Mask”
- Gentle and Soothing Formulation Often Mentioned Sometimes Noted “refreshing sensation — Medicube PDRN Pink Collagen Gel Mask” “Did not cause any irritation — Medicube Red Foam Cleanser” “no tingling or burning — Medicube PDRN Pink Peptide Serum” “Watery consistency — SK-II Facial Treatment Clear Lotion”
- Brightening and Fading Spots Sometimes Noted Often Mentioned “Skin looks brighter — SK-II Genoptics Spot Essence” “My skin is glowing now. — SK-II Genoptics Ultraura Essence” “Reduced sun spots — SK-II Genoptics Spot Essence” “Dark spots go away faster — Medicube Deep Vita C Pad”
- High Price and Cost Sometimes Noted Mostly Mentioned “tube is tiny for the price — Medicube Collagen Night Wrapping Mask” “price is steep — Medicube PDRN Pink Collagen Gel Mask” “price is a bit steep — Medicube Red Succinic Acid Peeling Pad” “way too expensive — SK-II Facial Treatment Essence”
- Unpleasant Fragrance or Scent Often Mentioned Often Mentioned “slightly fishy smell — Medicube PDRN Pink Peptide Serum” “smells like old lady perfume — Medicube Collagen Jelly Cream” “smells like dirty feet — SK-II Facial Treatment Essence” “smells slightly like saliva — SK-II Facial Treatment Mask”
- Product Design, Quantity and Application Issues Often Mentioned Rarely Noted “cotton is too thick and heavy — SK-II Facial Treatment Mask” “messy — Medicube PDRN Pink Collagen Gel Mask”
- Irritation and Breakouts Often Mentioned Sometimes Noted “caused redness and sensitivity — Medicube Zero Pore Pad” “woke up with whiteheads — Medicube Collagen Night Wrapping Mask” “caused tiny red bumps — SK-II Facial Treatment Essence” “Small bumps — SK-II Facial Treatment Clear Lotion”
- Sticky and Heavy Residue Often Mentioned Rarely Noted “dried to a tacky finish — SK-II Facial Treatment Mask” “quite thick consistency — SK-II Skinpower Advanced Cream” “hair sticks to my face — Medicube Collagen Jelly Cream”

### Medicube vs SK-II routines for dry skin

#### Medicube-focused routine

- Cleanser: [Zero Foam Cleanser](https://lovi.care/skincare/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [$29.33 at Amazon](https://www.amazon.com/dp/B0GF8DLCRW?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/p/medicube/triple-collagen-toner/for/dry-skin) — High fit — [$18.30 at Amazon](https://www.amazon.com/dp/B085VS2J3T?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/p/medicube/age-r-booster-gel/for/dry-skin) — Superior fit — [$29.97 at Amazon](https://www.amazon.com/dp/B0B4S7P792?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — [$15.99 at Amazon](https://www.amazon.com/dp/B0DKJ63Y6B?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [$21.70 at Amazon](https://www.amazon.com/dp/B084Q16G8D?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [One Day Exosome Shot 2000](https://lovi.care/skincare/p/medicube/one-day-exosome-shot-2000/for/dry-skin) — High fit — [$19.99 at Amazon](https://www.amazon.com/dp/B0DQCJ9T9N?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Collagen Night Wrapping Mask](https://lovi.care/skincare/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit — [$19.00 at Amazon](https://www.amazon.com/dp/B0BRMYHMS5?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week

#### SK-II-focused routine

- Cleanser: [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — [$19.99 at Amazon](https://www.amazon.com/dp/B01N7T7JKJ?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — [$16.99 at Amazon](https://www.amazon.com/dp/B08Q6WZ6J1?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Facial Treatment Essence](https://lovi.care/skincare/p/sk-ii/facial-treatment-essence/for/dry-skin) — High fit — [$99.00 at Amazon](https://www.amazon.com/dp/B000H723LU?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — [$15.99 at Amazon](https://www.amazon.com/dp/B0DKJ63Y6B?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Facial Treatment Cleansing Oil](https://lovi.care/skincare/p/sk-ii/facial-treatment-cleansing-oil/for/dry-skin) — High fit — [$75.00 at Amazon](https://www.amazon.com/dp/B084M1R6RH?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [Genoptics Ultraura Essence](https://lovi.care/skincare/p/sk-ii/genoptics-ultraura-essence/for/dry-skin) — High fit — [$265.00 at Amazon](https://www.amazon.com/dp/B0CVR58C7P?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Facial Treatment Mask](https://lovi.care/skincare/p/sk-ii/facial-treatment-mask/for/dry-skin) — High fit — [$100.00 at Amazon](https://www.amazon.com/dp/B078MQP5ZF?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week

[Buy Medicube routine · $154.28 · 91% fit](https://www.amazon.com/gp/aws/cart/add.html?ASIN.1=B0GF8DLCRW&Quantity.1=1&ASIN.2=B085VS2J3T&Quantity.2=1&ASIN.3=B0B4S7P792&Quantity.3=1&ASIN.4=B0DKJ63Y6B&Quantity.4=1&ASIN.5=B084Q16G8D&Quantity.5=1&ASIN.6=B0DQCJ9T9N&Quantity.6=1&ASIN.7=B0BRMYHMS5&Quantity.7=1&AssociateTag=lovi-care-web-routine-20) [Buy SK-II routine · $591.97 · 91% fit](https://www.amazon.com/gp/aws/cart/add.html?ASIN.1=B01N7T7JKJ&Quantity.1=1&ASIN.2=B08Q6WZ6J1&Quantity.2=1&ASIN.3=B000H723LU&Quantity.3=1&ASIN.4=B0DKJ63Y6B&Quantity.4=1&ASIN.5=B084M1R6RH&Quantity.5=1&ASIN.6=B0CVR58C7P&Quantity.6=1&ASIN.7=B078MQP5ZF&Quantity.7=1&AssociateTag=lovi-care-web-routine-20) [See multi-brand routine · 99% fit](https://lovi.care/skincare/skin/dry-skin)

### Medicube vs SK-II routines for oily skin

#### SK-II-focused routine

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [$15.97 at Amazon](https://www.amazon.com/dp/B01N1LL62W?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Some By Mi Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — [$15.60 at Amazon](https://www.amazon.com/dp/B08125WDCF?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Facial Treatment Essence](https://lovi.care/skincare/p/sk-ii/facial-treatment-essence/for/oily-skin) — Average fit — [$99.00 at Amazon](https://www.amazon.com/dp/B000H723LU?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — [$14.97 at Amazon](https://www.amazon.com/dp/B00F97FHAW?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Facial Treatment Cleansing Oil](https://lovi.care/skincare/p/sk-ii/facial-treatment-cleansing-oil/for/oily-skin) — Average fit — [$75.00 at Amazon](https://www.amazon.com/dp/B084M1R6RH?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Facial Treatment Clear Lotion](https://lovi.care/skincare/p/sk-ii/facial-treatment-clear-lotion/for/oily-skin) — High fit — [$80.00 at Amazon](https://www.amazon.com/dp/B072C3MCDH?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Genoptics Ultraura Essence](https://lovi.care/skincare/p/sk-ii/genoptics-ultraura-essence/for/oily-skin) — High fit — [$265.00 at Amazon](https://www.amazon.com/dp/B0CVR58C7P?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [$69.00 at Amazon](https://www.amazon.com/dp/B071ZBJPH7?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Revision Skincare Black Mask](https://lovi.care/skincare/p/revision-skincare/black-mask/for/oily-skin) — Superior fit — [$79.00 at Amazon](https://www.amazon.com/dp/B0DQ5XJ5FK?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/p/medicube/red-foam-cleanser/for/oily-skin) — High fit — [$14.90 at Amazon](https://www.amazon.com/dp/B073ZBXSJD?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/p/medicube/triple-collagen-toner/for/oily-skin) — High fit — [$18.30 at Amazon](https://www.amazon.com/dp/B085VS2J3T?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/p/medicube/age-r-booster-gel/for/oily-skin) — High fit — [$29.97 at Amazon](https://www.amazon.com/dp/B0B4S7P792?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — [$14.97 at Amazon](https://www.amazon.com/dp/B00F97FHAW?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [$50.00 at Amazon](https://www.amazon.com/dp/B0DNJKPSB8?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [$18.90 at Amazon](https://www.amazon.com/dp/B09V7Z4TJG?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [$69.00 at Amazon](https://www.amazon.com/dp/B071ZBJPH7?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/p/medicube/zero-pore-blackhead-mud-mask/for/oily-skin) — Average fit — [$18.90 at Amazon](https://www.amazon.com/dp/B0D1G7XF9X?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week

[Buy SK-II routine · $713.54 · 89% fit](https://www.amazon.com/gp/aws/cart/add.html?ASIN.1=B01N1LL62W&Quantity.1=1&ASIN.2=B08125WDCF&Quantity.2=1&ASIN.3=B000H723LU&Quantity.3=1&ASIN.4=B00F97FHAW&Quantity.4=1&ASIN.5=B084M1R6RH&Quantity.5=1&ASIN.6=B072C3MCDH&Quantity.6=1&ASIN.7=B0CVR58C7P&Quantity.7=1&ASIN.8=B071ZBJPH7&Quantity.8=1&ASIN.9=B0DQ5XJ5FK&Quantity.9=1&AssociateTag=lovi-care-web-routine-20) [Buy Medicube routine · $234.94 · 88% fit](https://www.amazon.com/gp/aws/cart/add.html?ASIN.1=B073ZBXSJD&Quantity.1=1&ASIN.2=B085VS2J3T&Quantity.2=1&ASIN.3=B0B4S7P792&Quantity.3=1&ASIN.4=B00F97FHAW&Quantity.4=1&ASIN.5=B0DNJKPSB8&Quantity.5=1&ASIN.6=B09V7Z4TJG&Quantity.6=1&ASIN.7=B071ZBJPH7&Quantity.7=1&ASIN.8=B0D1G7XF9X&Quantity.8=1&AssociateTag=lovi-care-web-routine-20) [See multi-brand routine · 98% fit](https://lovi.care/skincare/skin/oily-skin)

### Medicube vs SK-II routines for combination skin

#### SK-II-focused routine

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — [$28.08 at Amazon](https://www.amazon.com/dp/B00AU9EBTC?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Paula's Choice Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — [$25.60 at Amazon](https://www.amazon.com/dp/B008EPPIQ4?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Facial Treatment Essence](https://lovi.care/skincare/p/sk-ii/facial-treatment-essence/for/combination-skin) — High fit — [$99.00 at Amazon](https://www.amazon.com/dp/B000H723LU?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — [$14.97 at Amazon](https://www.amazon.com/dp/B00F97FHAW?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Facial Treatment Cleansing Oil](https://lovi.care/skincare/p/sk-ii/facial-treatment-cleansing-oil/for/combination-skin) — Average fit — [$75.00 at Amazon](https://www.amazon.com/dp/B084M1R6RH?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Facial Treatment Clear Lotion](https://lovi.care/skincare/p/sk-ii/facial-treatment-clear-lotion/for/combination-skin) — High fit — [$80.00 at Amazon](https://www.amazon.com/dp/B072C3MCDH?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Genoptics Ultraura Essence](https://lovi.care/skincare/p/sk-ii/genoptics-ultraura-essence/for/combination-skin) — High fit — [$265.00 at Amazon](https://www.amazon.com/dp/B0CVR58C7P?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [$69.00 at Amazon](https://www.amazon.com/dp/B071ZBJPH7?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [HERBIVORE Botanicals Blue Tansy BHA and Enzyme Pore Refining Mask](https://lovi.care/skincare/p/herbivore-botanicals/blue-tansy-bha-and-enzyme-pore-refining-mask/for/combination-skin) — Superior fit — [$58.00 at Amazon](https://www.amazon.com/dp/B015RRNQCY?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/p/medicube/red-foam-cleanser/for/combination-skin) — High fit — [$14.90 at Amazon](https://www.amazon.com/dp/B073ZBXSJD?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/p/medicube/triple-collagen-toner/for/combination-skin) — High fit — [$18.30 at Amazon](https://www.amazon.com/dp/B085VS2J3T?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/p/medicube/age-r-booster-gel/for/combination-skin) — High fit — [$29.97 at Amazon](https://www.amazon.com/dp/B0B4S7P792?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — [$14.97 at Amazon](https://www.amazon.com/dp/B00F97FHAW?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [$50.00 at Amazon](https://www.amazon.com/dp/B0DNJKPSB8?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/p/medicube/zero-pore-pad/for/combination-skin) — Superior fit — [$18.90 at Amazon](https://www.amazon.com/dp/B09V7Z4TJG?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [$69.00 at Amazon](https://www.amazon.com/dp/B071ZBJPH7?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/p/medicube/zero-pore-blackhead-mud-mask/for/combination-skin) — Average fit — [$18.90 at Amazon](https://www.amazon.com/dp/B0D1G7XF9X?tag=lovi-care-web-routine-20&linkCode=osi&th=1&psc=1) — Once a week

[Buy SK-II routine · $714.65 · 89% fit](https://www.amazon.com/gp/aws/cart/add.html?ASIN.1=B00AU9EBTC&Quantity.1=1&ASIN.2=B008EPPIQ4&Quantity.2=1&ASIN.3=B000H723LU&Quantity.3=1&ASIN.4=B00F97FHAW&Quantity.4=1&ASIN.5=B084M1R6RH&Quantity.5=1&ASIN.6=B072C3MCDH&Quantity.6=1&ASIN.7=B0CVR58C7P&Quantity.7=1&ASIN.8=B071ZBJPH7&Quantity.8=1&ASIN.9=B015RRNQCY&Quantity.9=1&AssociateTag=lovi-care-web-routine-20) [Buy Medicube routine · $234.94 · 88% fit](https://www.amazon.com/gp/aws/cart/add.html?ASIN.1=B073ZBXSJD&Quantity.1=1&ASIN.2=B085VS2J3T&Quantity.2=1&ASIN.3=B0B4S7P792&Quantity.3=1&ASIN.4=B00F97FHAW&Quantity.4=1&ASIN.5=B0DNJKPSB8&Quantity.5=1&ASIN.6=B09V7Z4TJG&Quantity.6=1&ASIN.7=B071ZBJPH7&Quantity.7=1&ASIN.8=B0D1G7XF9X&Quantity.8=1&AssociateTag=lovi-care-web-routine-20) [See multi-brand routine · 97% fit](https://lovi.care/skincare/skin/combination-skin)

## Questions and answers

### Medicube or SK-II: which is better?

Medicube and SK-II are both strong options, with Medicube offering products on this page tailored for dry, oily, and oily acne-prone skin, while SK-II focuses on dry, acne-prone, and oily skin types. Both brands tie across several skin types in routine fit, though SK-II achieves a superior fit for acne-prone skin.

### What is the difference between Medicube and SK-II?

Medicube is a South Korean brand founded in 2016 that relies on key ingredients like [niacinamide](https://lovi.care/skincare/ingredients/niacinamide) and [collagen](https://lovi.care/skincare/ingredients/collagen), whereas SK-II is a Japanese brand established in 1980 centered around its signature Pitera ingredient. The products on this page show that Medicube tends to offer better soothing formulations and packaging convenience, while SK-II does better with brightening and fading spots.

### Medicube or SK-II for dry skin?

Both Medicube and SK-II are a Superior fit for dry skin according to Lovi. Medicube offers deep hydration moisturizers, while SK-II features a fragrance-free routine powered by Pitera.

### Medicube or SK-II: which moisturizer is better?

Both Medicube and SK-II offer highly rated moisturizers on the products on this page, with Medicube standing out for deep hydration and SK-II featuring its signature Pitera ingredient. The products on this page for both brands generally help improve skin moisture and texture, though personal preferences for texture and scent may vary.

### Which is more affordable, Medicube or SK-II?

SK-II is generally more expensive, whereas Medicube faces review complaints regarding high prices and cost issues for the products on this page.

### Which brand uses fragrance in its skincare products, Medicube or SK-II?

Medicube includes fragrance in some of its products on this page, specifically the Collagen Jelly Cream and Deep Vita A [Retinol](https://lovi.care/skincare/ingredients/retinol) [Serum](https://lovi.care/skincare/ingredients/serum), while SK-II lists no fragrance in any of its products.

### Which brand has a better rating for brightening and fading spots?

SK-II does better than Medicube for brightening and fading spots.

### What are the founding years and home countries of Medicube and SK-II?

Medicube was founded in 2016 in South Korea, and SK-II was founded in 1980 in Japan.

### Medicube or SK-II for oily skin?

Both Medicube and SK-II are good options for oily skin, with Lovi giving both brands a High routine fit level for this skin type. Reviewers note that Medicube products on this page help provide deep hydration and a radiant glow, while utilizing key ingredients like niacinamide and [salicylic acid](https://lovi.care/skincare/ingredients/salicylic-acid).

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or SK-II for sensitive skin?

Both Medicube and SK-II achieve a High routine fit level for sensitive skin among the products on this page. Reviewers note that Medicube tends to be gentle and soothing, while SK-II lists no fragrance across every product on this page.

### Medicube or SK-II for acne-prone skin?

Both brands fit acne-prone skin well, but SK-II has a Superior routine fit compared to Medicube's High level. The products on this page from SK-II rely on Pitera, while Medicube offers options featuring salicylic acid and niacinamide.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Nicotinamide w, Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol, D-pantothenyl alcohol · American Journal of Clinical Dermatology, 2002
- [Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/37377400/) Exosome cica · Journal of Cosmetic Dermatology, 2023
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Vitamin c derivatives · Experimental Dermatology, 2003
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Aha · Journal of Dermatological Science, 2017
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Tea tree oil reduces histamine-induced skin inflammation](https://pubmed.ncbi.nlm.nih.gov/12452873/) Tree · The British Journal of Dermatology, 2002
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) L-ascorbic acid 2-glucoside, Ascorbyl glucoside · Journal of Periodontology, 2009
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica flower extract · Journal of Ethnopharmacology, 2007
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin, Concentrated glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [Protective effects of Camellia japonica flower extract against urban air pollutants](https://pubmed.ncbi.nlm.nih.gov/30691451/) Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, D-pantothenyl alcohol · The Journal of Dermatological Treatment, 2017
- [Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28341613/) Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen extract · Nutrients, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) D-pantothenyl alcohol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Vitamin c derivatives · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid, Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract, Madecassoside, Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula](https://pubmed.ncbi.nlm.nih.gov/34198790/) Galactomyces ferment filtrate, Pitera essence, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate galactomyces ferment filtrate, Pitera ferment filtrate, Sk-ii pitera concentrate, Pitera · Journal of Clinical Medicine, 2021
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine](https://pubmed.ncbi.nlm.nih.gov/34284096/) Sophora angustifolia root extract, Sophora flavescens root extract · European Journal of Pharmaceutical Sciences, 2021
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis flower extract · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex](https://pubmed.ncbi.nlm.nih.gov/39205505/) Succinic acid · Journal of Cosmetic Dermatology, 2024
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide](https://pubmed.ncbi.nlm.nih.gov/19958429/) Undecylenoyl phenylalanine · Journal of Cosmetic Dermatology, 2009
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin](https://pubmed.ncbi.nlm.nih.gov/31033161/) Butylene glycol · Journal of Cosmetic Dermatology, 2019
- [A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines](https://pubmed.ncbi.nlm.nih.gov/19874316/) Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract](https://pubmed.ncbi.nlm.nih.gov/33410284/) Camellia japonica flower extract · FEBS Open Bio, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial](https://pubmed.ncbi.nlm.nih.gov/37726676/) Portulaca oleracea extract · BMC Oral Health, 2023
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed extract · Skin Pharmacology and Physiology, 2007
- [Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract](https://pubmed.ncbi.nlm.nih.gov/35403355/) Grape seed extract · Journal of Cosmetic Dermatology, 2022
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, D-pantothenyl alcohol · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer](https://pubmed.ncbi.nlm.nih.gov/35456214/) Galactomyces ferment filtrate, Pitera essence, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate galactomyces ferment filtrate, Pitera ferment filtrate, Sk-ii pitera concentrate, Pitera · Journal of Clinical Medicine, 2022
- [Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin](https://pubmed.ncbi.nlm.nih.gov/20883290/) Sodium salicylate · Journal of Cosmetic Dermatology, 2010
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Composition characterization and clinical efficacy study of a salmon egg extract](https://pubmed.ncbi.nlm.nih.gov/23738607/) Salmon egg extract · International Journal of Cosmetic Science, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate vitamin e · Scientific Reports, 2025
- [Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations](https://pubmed.ncbi.nlm.nih.gov/31435711/) Ethanolamine · Archives of Toxicology, 2019
- [Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels for topical management of dry skin](https://pubmed.ncbi.nlm.nih.gov/41224059/) Xanthan gum · International Journal of Biological Macromolecules, 2025
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) L-ascorbic acid 2-glucoside, Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022
- [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) Sodium dna, Pdrn polydeoxyribonucleotide · International Journal of Molecular Sciences, 2025
- [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) Sodium dna · International Journal of Biological Macromolecules, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study](https://pubmed.ncbi.nlm.nih.gov/36769815/) Galactomyces ferment filtrate, Pitera essence, Pitera ferment filtrate galactomyces ferment filtrate, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate, Pitera · Journal of Clinical Medicine, 2023
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) L-ascorbic acid 2-glucoside, Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color](https://pubmed.ncbi.nlm.nih.gov/33938432/) Galactomyces ferment filtrate, Sk-ii pitera concentrate, Galactomyces ferment filtrate pitera ferment filtrate · Skinmed, 2021
- [Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42147661/) Ascorbyl glucoside · Cureus, 2026

## The brands

- Korean skincare: [Medicube](https://lovi.care/skincare/brands/medicube)
- Japanese skincare: [SK-II](https://lovi.care/skincare/brands/sk-ii)

## More comparisons

- [SKIN1004 vs Medicube](https://lovi.care/skincare/compare/skin1004-vs-medicube)
- [SKIN1004 vs SK-II](https://lovi.care/skincare/compare/skin1004-vs-sk-ii)
- [Anua vs Medicube](https://lovi.care/skincare/compare/anua-vs-medicube)
- [Anua vs SK-II](https://lovi.care/skincare/compare/anua-vs-sk-ii)
- [Medicube vs The Ordinary](https://lovi.care/skincare/compare/medicube-vs-the-ordinary)
- [Medicube vs Beauty of Joseon](https://lovi.care/skincare/compare/medicube-vs-beauty-of-joseon)
- [Medicube vs COSRX](https://lovi.care/skincare/compare/medicube-vs-cosrx)
- [Medicube vs CeraVe](https://lovi.care/skincare/compare/medicube-vs-cerave)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/compare/medicube-vs-la-roche-posay)
- [Medicube vs Dr. Althea](https://lovi.care/skincare/compare/medicube-vs-dr-althea)
- [Medicube vs Some By Mi](https://lovi.care/skincare/compare/medicube-vs-some-by-mi)
- [Medicube vs Torriden](https://lovi.care/skincare/compare/medicube-vs-torriden)
- [Medicube vs celimax](https://lovi.care/skincare/compare/medicube-vs-celimax)
- [Medicube vs Purito](https://lovi.care/skincare/compare/medicube-vs-purito)
- [Medicube vs Cetaphil](https://lovi.care/skincare/compare/medicube-vs-cetaphil)
- [Medicube vs Paula's Choice](https://lovi.care/skincare/compare/medicube-vs-paula-s-choice)
- [Medicube vs Neutrogena](https://lovi.care/skincare/compare/medicube-vs-neutrogena)
- [Medicube vs Kiehl's](https://lovi.care/skincare/compare/medicube-vs-kiehl-s)
- [Medicube vs Caudalie](https://lovi.care/skincare/compare/medicube-vs-caudalie)
- [Medicube vs Dermalogica](https://lovi.care/skincare/compare/medicube-vs-dermalogica)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medicube-vs-sk-ii (this page)
- United Kingdom: https://lovi.care/skincare/uk/compare/medicube-vs-sk-ii
- Ireland: https://lovi.care/skincare/ie/compare/medicube-vs-sk-ii
- Germany: https://lovi.care/skincare/de/compare/medicube-vs-sk-ii
- France: https://lovi.care/skincare/fr/compare/medicube-vs-sk-ii
- Italy: https://lovi.care/skincare/it/compare/medicube-vs-sk-ii
- Netherlands: https://lovi.care/skincare/nl/compare/medicube-vs-sk-ii
- Spain: https://lovi.care/skincare/es/compare/medicube-vs-sk-ii
- Canada: https://lovi.care/skincare/ca/compare/medicube-vs-sk-ii
- Australia: https://lovi.care/skincare/au/compare/medicube-vs-sk-ii
- Singapore: https://lovi.care/skincare/sg/compare/medicube-vs-sk-ii
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medicube-vs-sk-ii
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medicube-vs-sk-ii