# L'Oreal Paris vs Sesderma

Page: https://lovi.care/skincare/compare/l-oreal-paris-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

L'Oreal Paris and Sesderma are a French skincare brand founded in 1909 and a Spanish skincare brand founded in 1989, respectively. The French brand is beloved for its thoughtful range of [serums](https://lovi.care/skincare/ingredients/serum), moisturizers, masks, and eye products featuring [hyaluronic acid](https://lovi.care/skincare/ingredients/hyaluronic-acid) and [glycerin](https://lovi.care/skincare/ingredients/glycerin), suiting oily skin and combination skin best. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas, suiting sensitive, hyperpigmented, and aging skin types best. While both offer standout products for acne-prone skin such as the Revitalift and the Azelac RU Serum, they differ in their origin, founding year, key ingredients, and target skin types.

L'Oreal Paris is a French skincare brand founded in 1909 and owned by L'Oréal S.A..

[en.wikipedia.org](https://en.wikipedia.org/wiki/L%27Or%C3%A9al) [loreal.com](https://www.loreal.com/en/culture-and-heritage/) [loreal-paris.co.uk](https://www.loreal-paris.co.uk/our-history) [cosmeticsbusiness.com](https://cosmeticsbusiness.com/loreal-paris-laetitia-toupet-delon-global-brand-president)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular L'Oreal Paris and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pge325c1cd44).

### Popular L'Oreal Paris vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [$60.00 at Amazon](https://www.amazon.com/dp/B00987RKWW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### L'Oreal Paris

- [Age Perfect Cell Renewal Midnight Cream](https://lovi.care/skincare/p/l-oreal-paris/age-perfect-cell-renewal-midnight-cream/for/dry-sensitive-skin) — High fit
- [Revitalift](https://lovi.care/skincare/p/l-oreal-paris/revitalift/for/oily-acne-prone-skin) — High fit — [$22.99 at Amazon](https://www.amazon.com/dp/B07GVCVYB9?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Pure-Clay Mask](https://lovi.care/skincare/p/l-oreal-paris/pure-clay-mask/for/oily-skin) — Average fit
- [Revitalift Anti-Wrinkle + Firming Night Cream](https://lovi.care/skincare/p/l-oreal-paris/revitalift-anti-wrinkle-firming-night-cream/for/dry-skin) — Average fit — [$12.71 at Amazon](https://www.amazon.com/dp/B000KONYPY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Revitalift Anti-Wrinkle + Firming Eye Cream](https://lovi.care/skincare/p/l-oreal-paris/revitalift-anti-wrinkle-firming-eye-cream/for/mature-skin) — High fit — [$12.25 at Amazon](https://www.amazon.com/dp/B000KOLXKM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Glycolic Bright](https://lovi.care/skincare/p/l-oreal-paris/glycolic-bright/for/acne-prone-skin) — Average fit
- [Bright Reveal 12% Niacinamide Dark Spot Serum](https://lovi.care/skincare/p/l-oreal-paris/bright-reveal-12-niacinamide-dark-spot-serum/for/combination-skin) — Average fit — [$39.99 at Amazon](https://www.amazon.com/dp/B0CJVKZK13?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Dark Spot Exfoliant Peel](https://lovi.care/skincare/p/l-oreal-paris/dark-spot-exfoliant-peel/for/oily-acne-prone-skin) — Average fit

### L'Oreal Paris vs Sesderma [serums](https://lovi.care/skincare/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [$60.00 at Amazon](https://www.amazon.com/dp/B00987RKWW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### L'Oreal Paris

- [Revitalift](https://lovi.care/skincare/p/l-oreal-paris/revitalift/for/oily-acne-prone-skin) — High fit — [$22.99 at Amazon](https://www.amazon.com/dp/B07GVCVYB9?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Glycolic Bright](https://lovi.care/skincare/p/l-oreal-paris/glycolic-bright/for/acne-prone-skin) — Average fit
- [Bright Reveal 12% Niacinamide Dark Spot Serum](https://lovi.care/skincare/p/l-oreal-paris/bright-reveal-12-niacinamide-dark-spot-serum/for/combination-skin) — Average fit — [$39.99 at Amazon](https://www.amazon.com/dp/B0CJVKZK13?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Dark Spot Exfoliant Peel](https://lovi.care/skincare/p/l-oreal-paris/dark-spot-exfoliant-peel/for/oily-acne-prone-skin) — Average fit
- [Revitalift Laser Pure Retinol Night Serum](https://lovi.care/skincare/p/l-oreal-paris/revitalift-laser-pure-retinol-night-serum/for/mature-skin) — Average fit — [$29.88 at Amazon](https://www.amazon.com/dp/B08C5PHRM1?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### L'Oreal Paris or Sesderma: which is better?

L'Oreal Paris offers a much broader range of products on this page with high Lovi fit levels for oily, combination, and acne-prone skin, whereas Sesderma features only a single [serum](https://lovi.care/skincare/ingredients/serum). Reviewers note that L'Oreal Paris products provide deep hydration and radiance, though some users report skin irritation and strong fragrances.

### What is the difference between L'Oreal Paris and Sesderma?

L'Oreal Paris offers a wide range of ten products on this page featuring [hyaluronic acid](https://lovi.care/skincare/ingredients/hyaluronic-acid) and [glycerin](https://lovi.care/skincare/ingredients/glycerin), whereas Sesderma is represented by just one product, Azelac RU Serum. Reviewers note that L'Oreal Paris products frequently provide deep hydration and radiance, but they can also cause skin irritation and stinging.

### Which is more affordable, L'Oreal Paris or Sesderma?

L'Oreal Paris offers value and affordability among the products on this page, whereas Sesderma has no brand-focused routine or affordability information listed.

### Which causes fewer breakouts, L'Oreal Paris or Sesderma?

For acne-prone skin, Lovi rates the Azelac RU Serum by Sesderma as High, while the products on this page by L'Oreal Paris range from Low to High depending on the specific item.

### Between L'Oreal Paris and Sesderma, which brand was founded earlier and in which country?

L'Oreal Paris was founded earlier in France in 1909, while Sesderma was founded in Spain in 1989.

### How do the fragrance profiles of the skincare products compare between L'Oreal Paris and Sesderma on this page?

On this page, L'Oreal Paris offers a mix with half of its products listing no fragrance, whereas Sesderma includes fragrance in its sole product.

### Which brand offers more products for dry sensitive skin, L'Oreal Paris or Sesderma?

L'Oreal Paris offers more products on this page for dry sensitive skin than Sesderma, including the Age Perfect Cell Renewal Midnight Cream which has a High fit level for this skin type. Hyaluronic acid helps provide deep hydration and moisturization.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica, Centella asiatica extract · Indian Journal of Pharmaceutical Sciences, 2016
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid, Ferulic acid · Journal of Cosmetic Dermatology, 2020
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Pro-retinol a · Journal of Controlled Release, 2018
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system](https://pubmed.ncbi.nlm.nih.gov/21411295/) Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract · Molecules, 2023
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Capryloyl salicylic acid, Citric acid · Journal of Cosmetic Dermatology, 2021
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants](https://pubmed.ncbi.nlm.nih.gov/16439809/) Dimethicone · Ostomy/wound Management, 2005
- [Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles](https://pubmed.ncbi.nlm.nih.gov/32783330/) Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Retinyl palmitate · Journal of Cosmetic Dermatology, 2013
- [Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid](https://pubmed.ncbi.nlm.nih.gov/9603669/) Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998
- [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Capryloyl salicylic acid · Journal of Drugs in Dermatology, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study](https://pubmed.ncbi.nlm.nih.gov/41647767/) Hydroxypropyl tetrahydropyrantriol · The Journal of Clinical and Aesthetic Dermatology, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Moroccan lava clay · Journal of Cosmetic Dermatology, 2025

## The brands

- French skincare: [L'Oreal Paris](https://lovi.care/skincare/brands/l-oreal-paris)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/brands/sesderma)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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