# Hada Labo vs Natura Bissé

Page: https://lovi.care/skincare/compare/hada-labo-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Hada Labo and Natura Bissé are distinct skincare brands founded in Japan and Spain, respectively. The Japanese line is celebrated for its hydrating toners, gentle makeup removers, and nourishing moisturizers driven by advanced science, while the Spanish house is beloved for its luxurious moisturizers and advanced formulas. The former suits dry skin and acne-prone skin best with standout options like the Gokujyun Lotion, Shirojyun Premium Whitening Lotion, and Gokujun Premium, whereas the latter suits mature, dry, and sensitive skin best with the Diamond Extreme for acne-prone skin. Ultimately, both offer carefully crafted treatments designed to restore balance, vitality, and essential hydration to the complexion.

Hada Labo is a Japanese skincare brand founded in 2004 and owned by Rohto Pharmaceutical Co., Ltd..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Hada_Labo) [hadalabosa.co.za](https://hadalabosa.co.za/about-hada-labo/) [hadalabotokyo.pl](https://www.hadalabotokyo.pl/en/the-world-of-hada-labo/brand-history/)

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular Hada Labo and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg02f8f3bae2).

### Popular Hada Labo vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [$420.00 at Amazon](https://www.amazon.com/dp/B0BKLRMKZV?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### Hada Labo

- [Gokujyun Lotion](https://lovi.care/skincare/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit — [$18.04 at Amazon](https://www.amazon.com/dp/B013HHJV0C?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Gokujun Premium](https://lovi.care/skincare/p/hada-labo/gokujun-premium/for/dry-skin) — Superior fit
- [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/p/hada-labo/shirojyun-premium-whitening-lotion/for/dry-skin) — High fit — [$16.79 at Amazon](https://www.amazon.com/dp/B06WP7TZV8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Gokujyun Cleansing Oil](https://lovi.care/skincare/p/hada-labo/gokujyun-cleansing-oil/for/dry-skin) — Superior fit
- [Gokujyun Perfect Gel](https://lovi.care/skincare/p/hada-labo/gokujyun-perfect-gel/for/dry-skin) — High fit
- [Premium Whitening Lotion (Light)](https://lovi.care/skincare/p/hada-labo/premium-whitening-lotion-light/for/dry-sensitive-skin) — High fit

## Questions and answers

### Hada Labo or Natura Bissé: which is better?

Hada Labo is a better choice for fragrance-free hydration, fitting dry, acne-prone, and oily skin best with lightweight [hyaluronic acid](https://lovi.care/skincare/ingredients/hyaluronic-acid) toners. Natura Bissé offers the luxury Diamond Extreme moisturizer, but it contains fragrance and provides a mature skin fit.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Hada Labo and Natura Bissé?

Hada Labo is a Japanese brand founded in 2004 that features fragrance-free formulas with hyaluronic acid, achieving superior Lovi fit levels for dry and sensitive skin types across the products on this page. In contrast, Natura Bissé is a Spanish brand founded in 1979 whose featured moisturizer contains fragrance and achieves a superior Lovi fit for mature skin.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Hada Labo or Natura Bissé: which moisturizer is better?

For moisturizers, Hada Labo Gokujyun Perfect Gel has High Lovi fit for dry and dry sensitive skin, while Natura Bissé Diamond Extreme has Superior fit for mature skin. Topical hyaluronic acid helps improve skin quality and signs of aging.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Hada Labo or Natura Bissé?

Hada Labo is more affordable than Natura Bissé, as reviewers often mention its value and versatility.

### Which causes fewer breakouts, Hada Labo or Natura Bissé?

Hada Labo is a better fit for acne-prone skin, achieving High or Average Lovi fit levels across its acne-prone products, whereas Natura Bissé's Diamond Extreme is rated Low for oily acne-prone skin and Average for acne-prone skin. Hada Labo products on this page list no fragrance, which helps minimize irritation.

### Which brand uses fragrance in its products, Hada Labo or Natura Bissé?

Natura Bissé uses fragrance in its products on this page, whereas every product from Hada Labo lists no fragrance in its ingredients.

### How do the founding years and countries of origin compare between Hada Labo and Natura Bissé?

Hada Labo was founded in 2004 in Japan, whereas Natura Bissé was established earlier in 1979 in Spain.

### Which brand has more products listed on the page with a Superior fit for dry skin?

Hada Labo has more products listed on the page with a Superior fit for dry skin, including the Gokujyun Lotion, Gokujun Premium, and Gokujyun Cleansing Oil. Topical hyaluronic acid, a key ingredient across Hada Labo products, helps improve skin quality and hydration.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [Preparation and characterization of a lecithin nanoemulsion as a topical delivery system](https://pubmed.ncbi.nlm.nih.gov/20652152/) Hydroxylated lecithin · Nanoscale Research Letters, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [The anti-wrinkles properties of sodium acetylated hyaluronate](https://pubmed.ncbi.nlm.nih.gov/34708918/) Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides](https://pubmed.ncbi.nlm.nih.gov/36613524/) Glucosyl ceramide · International Journal of Molecular Sciences, 2022
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging](https://pubmed.ncbi.nlm.nih.gov/42728863/) Sodium acetylhyaluronate · Skin Research and Technology, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- Japanese skincare: [Hada Labo](https://lovi.care/skincare/brands/hada-labo)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/brands/natura-bisse)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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