# Hada Labo vs Mesoestetic

Page: https://lovi.care/skincare/compare/hada-labo-vs-mesoestetic

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Hada Labo and Mesoestetic are two distinct skincare lines, with the Japanese brand founded in 2004 and the Spanish brand established in 1984. The first brand is deeply loved for its hydrating toners, gentle makeup removers, and nourishing moisturizers, while the second is beloved for its targeted [serums](https://lovi.care/skincare/ingredients/serum). Products from the first brand suit dry and acne-prone skin best, whereas the second brand suits mature, sensitive, and uneven skin. Ultimately, they differ in their specialized ingredients and formulations, offering tailored options ranging from the Gokujyun Lotion to the Cosmelan 2.

Hada Labo is a Japanese skincare brand founded in 2004 and owned by Rohto Pharmaceutical Co., Ltd..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Hada_Labo) [hadalabosa.co.za](https://hadalabosa.co.za/about-hada-labo/) [hadalabotokyo.pl](https://www.hadalabotokyo.pl/en/the-world-of-hada-labo/brand-history/)

Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L..

[mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk)

This page compares some of the most popular Hada Labo and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgd80903aade).

### Popular Hada Labo vs Mesoestetic products

#### Hada Labo

- [Gokujyun Lotion](https://lovi.care/skincare/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit — [$18.04 at Amazon](https://www.amazon.com/dp/B013HHJV0C?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Gokujun Premium](https://lovi.care/skincare/p/hada-labo/gokujun-premium/for/dry-skin) — Superior fit
- [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/p/hada-labo/shirojyun-premium-whitening-lotion/for/dry-skin) — High fit — [$16.79 at Amazon](https://www.amazon.com/dp/B06WP7TZV8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Gokujyun Cleansing Oil](https://lovi.care/skincare/p/hada-labo/gokujyun-cleansing-oil/for/dry-skin) — Superior fit
- [Gokujyun Perfect Gel](https://lovi.care/skincare/p/hada-labo/gokujyun-perfect-gel/for/dry-skin) — High fit
- [Premium Whitening Lotion (Light)](https://lovi.care/skincare/p/hada-labo/premium-whitening-lotion-light/for/dry-sensitive-skin) — High fit

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

## Questions and answers

### Hada Labo or Mesoestetic: which is better?

Hada Labo is generally the better choice on this page, as its products achieve a Superior or High Lovi fit for most skin types, whereas Mesoestetic only reaches an Average or Low fit. Additionally, Hada Labo provides deep hydration and moisturization with its [hyaluronic acid](https://lovi.care/skincare/ingredients/hyaluronic-acid) formulations.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Hada Labo and Mesoestetic?

Hada Labo is a Japanese brand offering fragrance-free toners, cleansers, and moisturizers featuring hyaluronic acid that Lovi rates with Superior to Average fit for dry, acne-prone, and oily skin, whereas Mesoestetic is a Spanish brand represented on this page by Cosmelan 2 [serum](https://lovi.care/skincare/ingredients/serum), which Lovi rates with Average to Low fit across various skin types.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Hada Labo or Mesoestetic?

The page does not provide pricing information to compare the affordability of Hada Labo and Mesoestetic.

### Which causes fewer breakouts, Hada Labo or Mesoestetic?

Hada Labo products on this page are a High fit for acne-prone skin, while Mesoestetic Cosmelan 2 is an Average fit. Hada Labo reviews note that breakouts and clogged pores may sometimes occur.

### How do the founding years and countries of origin compare between Hada Labo and Mesoestetic?

Hada Labo was founded in 2004 in Japan, whereas Mesoestetic was founded in 1984 in Spain.

### Which of the two brands offers a wider variety of product types such as toners, cleansing oils, and moisturizers based on the page?

Hada Labo offers a wider variety of product types on this page, including multiple toners, a cleansing oil, and a moisturizer, whereas Mesoestetic only features a single serum.

### How does the presence of fragrance compare across all the products listed for Hada Labo and Mesoestetic?

Every product listed on this page for both Hada Labo and Mesoestetic contains no fragrance in its ingredients.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [Preparation and characterization of a lecithin nanoemulsion as a topical delivery system](https://pubmed.ncbi.nlm.nih.gov/20652152/) Hydroxylated lecithin · Nanoscale Research Letters, 2009
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [The anti-wrinkles properties of sodium acetylated hyaluronate](https://pubmed.ncbi.nlm.nih.gov/34708918/) Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides](https://pubmed.ncbi.nlm.nih.gov/36613524/) Glucosyl ceramide · International Journal of Molecular Sciences, 2022
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging](https://pubmed.ncbi.nlm.nih.gov/42728863/) Sodium acetylhyaluronate · Skin Research and Technology, 2026

## The brands

- Japanese skincare: [Hada Labo](https://lovi.care/skincare/brands/hada-labo)
- Spanish skincare: [Mesoestetic](https://lovi.care/skincare/brands/mesoestetic)

## More comparisons

- [SKIN1004 vs Hada Labo](https://lovi.care/skincare/compare/skin1004-vs-hada-labo)
- [SKIN1004 vs Mesoestetic](https://lovi.care/skincare/compare/skin1004-vs-mesoestetic)
- [Anua vs Hada Labo](https://lovi.care/skincare/compare/anua-vs-hada-labo)
- [Anua vs Mesoestetic](https://lovi.care/skincare/compare/anua-vs-mesoestetic)
- [Medicube vs Hada Labo](https://lovi.care/skincare/compare/medicube-vs-hada-labo)
- [Medicube vs Mesoestetic](https://lovi.care/skincare/compare/medicube-vs-mesoestetic)
- [The Ordinary vs Hada Labo](https://lovi.care/skincare/compare/the-ordinary-vs-hada-labo)
- [The Ordinary vs Mesoestetic](https://lovi.care/skincare/compare/the-ordinary-vs-mesoestetic)
- [Beauty of Joseon vs Hada Labo](https://lovi.care/skincare/compare/beauty-of-joseon-vs-hada-labo)
- [Beauty of Joseon vs Mesoestetic](https://lovi.care/skincare/compare/beauty-of-joseon-vs-mesoestetic)
- [COSRX vs Hada Labo](https://lovi.care/skincare/compare/cosrx-vs-hada-labo)
- [COSRX vs Mesoestetic](https://lovi.care/skincare/compare/cosrx-vs-mesoestetic)
- [CeraVe vs Hada Labo](https://lovi.care/skincare/compare/cerave-vs-hada-labo)
- [CeraVe vs Mesoestetic](https://lovi.care/skincare/compare/cerave-vs-mesoestetic)
- [La Roche-Posay vs Hada Labo](https://lovi.care/skincare/compare/la-roche-posay-vs-hada-labo)
- [La Roche-Posay vs Mesoestetic](https://lovi.care/skincare/compare/la-roche-posay-vs-mesoestetic)
- [Dr. Althea vs Hada Labo](https://lovi.care/skincare/compare/dr-althea-vs-hada-labo)
- [Dr. Althea vs Mesoestetic](https://lovi.care/skincare/compare/dr-althea-vs-mesoestetic)
- [Some By Mi vs Hada Labo](https://lovi.care/skincare/compare/some-by-mi-vs-hada-labo)
- [Some By Mi vs Mesoestetic](https://lovi.care/skincare/compare/some-by-mi-vs-mesoestetic)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/hada-labo-vs-mesoestetic (this page)
- United Kingdom: https://lovi.care/skincare/uk/compare/hada-labo-vs-mesoestetic
- Ireland: https://lovi.care/skincare/ie/compare/hada-labo-vs-mesoestetic
- Germany: https://lovi.care/skincare/de/compare/hada-labo-vs-mesoestetic
- France: https://lovi.care/skincare/fr/compare/hada-labo-vs-mesoestetic
- Italy: https://lovi.care/skincare/it/compare/hada-labo-vs-mesoestetic
- Netherlands: https://lovi.care/skincare/nl/compare/hada-labo-vs-mesoestetic
- Spain: https://lovi.care/skincare/es/compare/hada-labo-vs-mesoestetic
- Canada: https://lovi.care/skincare/ca/compare/hada-labo-vs-mesoestetic
- Australia: https://lovi.care/skincare/au/compare/hada-labo-vs-mesoestetic
- Singapore: https://lovi.care/skincare/sg/compare/hada-labo-vs-mesoestetic
- Saudi Arabia: https://lovi.care/skincare/sa/compare/hada-labo-vs-mesoestetic
- United Arab Emirates: https://lovi.care/skincare/ae/compare/hada-labo-vs-mesoestetic