# Galderma vs Mesoestetic

Page: https://lovi.care/skincare/compare/galderma-vs-mesoestetic

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Galderma and Mesoestetic are distinguished European skincare houses founded in the early 1980s that craft targeted [serums](https://lovi.care/skincare/ingredients/serum) with specialized active ingredients. The Swiss brand centers on effective options like Epiduo Gel and Benzac AC for oily and acne-prone skin, while the Spanish maker relies on gentle yet rigorous compositions such as Cosmelan 2 for mature, sensitive, and uneven skin. Ultimately, both offer meticulously formulated treatments, differing primarily in their ideal skin types and specific core ingredients.

Galderma is a Swiss skincare brand founded in 1981 and owned by Galderma Group AG.

[en.wikipedia.org](https://en.wikipedia.org/wiki/Galderma)

Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L..

[mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk)

This page compares some of the most popular Galderma and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgfd6d80f9b3).

### Popular Galderma vs Mesoestetic products

#### Galderma

- [Epiduo Gel](https://lovi.care/skincare/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit — [$34.97 at Amazon](https://www.amazon.com/dp/B0GSSCQ6J2?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Benzac AC 5](https://lovi.care/skincare/p/galderma/benzac-ac-5/for/oily-acne-prone-skin) — High fit
- [Benzac AC Mild Strength 2.5% Acne Gel](https://lovi.care/skincare/p/galderma/benzac-ac-mild-strength-2-5-acne-gel/for/oily-acne-prone-skin) — High fit

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

### Galderma vs Mesoestetic [serums](https://lovi.care/skincare/ingredients/serum) and treatments

#### Galderma

- [Epiduo Gel](https://lovi.care/skincare/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit — [$34.97 at Amazon](https://www.amazon.com/dp/B0GSSCQ6J2?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Benzac AC 5](https://lovi.care/skincare/p/galderma/benzac-ac-5/for/oily-acne-prone-skin) — High fit
- [Benzac AC Mild Strength 2.5% Acne Gel](https://lovi.care/skincare/p/galderma/benzac-ac-mild-strength-2-5-acne-gel/for/oily-acne-prone-skin) — High fit

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

## Questions and answers

### Galderma or Mesoestetic: which is better?

Galderma is a better fit for oily and acne-prone skin, achieving a High Lovi fit for those skin types with its effective acne-clearing [serums](https://lovi.care/skincare/ingredients/serum). However, reviewers note that the products on this page may cause severe dryness and irritation.

[The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/)

### What is the difference between Galderma and Mesoestetic?

Galderma features products on this page with a High Lovi fit for oily and acne-prone skin, while Mesoestetic offers an average fit for those skin types. Galderma serums are frequently noted as effective for clearing acne, though users may experience severe dryness and peeling.

[The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/)

### Which is more affordable, Galderma or Mesoestetic?

This page does not provide pricing information to compare the affordability of Galderma and Mesoestetic.

### Which causes fewer breakouts, Galderma or Mesoestetic?

Galderma is the better choice for acne because the products on this page have a High Lovi fit for oily and acne-prone skin, whereas Mesoestetic only has an Average fit. Galderma's acne serums help clear breakouts effectively, though users often note severe dryness and irritation.

[The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/)

### Between Galderma and Mesoestetic, which brand was founded earlier and in which country?

Galderma was founded earlier in Switzerland in 1981, while Mesoestetic was founded in Spain in 1984.

### How do the Lovi fit levels for acne-prone skin compare between Galderma's Epiduo Gel and Mesoestetic's Cosmelan 2?

Galderma's Epiduo Gel has a High Lovi fit level for acne-prone skin, whereas Mesoestetic's Cosmelan 2 has an Average fit level. This makes Epiduo Gel a better option for targeting acne-prone skin on this page.

[American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/) [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### What specific negative side effects do reviewers mostly mention about Galderma products?

Reviewers mostly mention that Galderma products cause severe dryness, peeling, irritation, and discomfort.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Topical benzoyl peroxide for acne](https://pubmed.ncbi.nlm.nih.gov/32175593/) Benzoyl peroxide, Benzoyl peroxide 25mg g · The Cochrane Database of Systematic Reviews, 2020
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018
- [Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure](https://pubmed.ncbi.nlm.nih.gov/33545336/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of Shoulder and Elbow Surgery, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Benzoyl peroxide, Benzoyl peroxide 25mg g · American Journal of Clinical Dermatology, 2022
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022
- [Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15](https://pubmed.ncbi.nlm.nih.gov/32224894/) Silicon dioxide · Antioxidants, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection](https://pubmed.ncbi.nlm.nih.gov/32395645/) Silicon dioxide · Heliyon, 2020
- [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023
- [Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies](https://pubmed.ncbi.nlm.nih.gov/37356627/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of the American Academy of Dermatology, 2023
- [Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation](https://pubmed.ncbi.nlm.nih.gov/37367119/) Carbomer 940 · Gels, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023

## The brands

- Swiss skincare: [Galderma](https://lovi.care/skincare/brands/galderma)
- Spanish skincare: [Mesoestetic](https://lovi.care/skincare/brands/mesoestetic)

## More comparisons

- [SKIN1004 vs Galderma](https://lovi.care/skincare/compare/skin1004-vs-galderma)
- [SKIN1004 vs Mesoestetic](https://lovi.care/skincare/compare/skin1004-vs-mesoestetic)
- [Anua vs Galderma](https://lovi.care/skincare/compare/anua-vs-galderma)
- [Anua vs Mesoestetic](https://lovi.care/skincare/compare/anua-vs-mesoestetic)
- [Medicube vs Galderma](https://lovi.care/skincare/compare/medicube-vs-galderma)
- [Medicube vs Mesoestetic](https://lovi.care/skincare/compare/medicube-vs-mesoestetic)
- [The Ordinary vs Galderma](https://lovi.care/skincare/compare/the-ordinary-vs-galderma)
- [The Ordinary vs Mesoestetic](https://lovi.care/skincare/compare/the-ordinary-vs-mesoestetic)
- [Beauty of Joseon vs Galderma](https://lovi.care/skincare/compare/beauty-of-joseon-vs-galderma)
- [Beauty of Joseon vs Mesoestetic](https://lovi.care/skincare/compare/beauty-of-joseon-vs-mesoestetic)
- [COSRX vs Galderma](https://lovi.care/skincare/compare/cosrx-vs-galderma)
- [COSRX vs Mesoestetic](https://lovi.care/skincare/compare/cosrx-vs-mesoestetic)
- [CeraVe vs Galderma](https://lovi.care/skincare/compare/cerave-vs-galderma)
- [CeraVe vs Mesoestetic](https://lovi.care/skincare/compare/cerave-vs-mesoestetic)
- [La Roche-Posay vs Galderma](https://lovi.care/skincare/compare/la-roche-posay-vs-galderma)
- [La Roche-Posay vs Mesoestetic](https://lovi.care/skincare/compare/la-roche-posay-vs-mesoestetic)
- [Dr. Althea vs Galderma](https://lovi.care/skincare/compare/dr-althea-vs-galderma)
- [Dr. Althea vs Mesoestetic](https://lovi.care/skincare/compare/dr-althea-vs-mesoestetic)
- [Some By Mi vs Galderma](https://lovi.care/skincare/compare/some-by-mi-vs-galderma)
- [Some By Mi vs Mesoestetic](https://lovi.care/skincare/compare/some-by-mi-vs-mesoestetic)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/galderma-vs-mesoestetic (this page)
- United Kingdom: https://lovi.care/skincare/uk/compare/galderma-vs-mesoestetic
- Ireland: https://lovi.care/skincare/ie/compare/galderma-vs-mesoestetic
- Germany: https://lovi.care/skincare/de/compare/galderma-vs-mesoestetic
- France: https://lovi.care/skincare/fr/compare/galderma-vs-mesoestetic
- Italy: https://lovi.care/skincare/it/compare/galderma-vs-mesoestetic
- Netherlands: https://lovi.care/skincare/nl/compare/galderma-vs-mesoestetic
- Spain: https://lovi.care/skincare/es/compare/galderma-vs-mesoestetic
- Canada: https://lovi.care/skincare/ca/compare/galderma-vs-mesoestetic
- Australia: https://lovi.care/skincare/au/compare/galderma-vs-mesoestetic
- Singapore: https://lovi.care/skincare/sg/compare/galderma-vs-mesoestetic
- Saudi Arabia: https://lovi.care/skincare/sa/compare/galderma-vs-mesoestetic
- United Arab Emirates: https://lovi.care/skincare/ae/compare/galderma-vs-mesoestetic