# Anessa vs Sesderma

Page: https://lovi.care/skincare/compare/anessa-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Anessa and Sesderma are distinguished skincare brands that offer advanced sunscreens, specialized [serums](https://lovi.care/skincare/ingredients/serum), and sophisticated formulas. Founded in Japan in 1992 and Spain in 1989 respectively, Anessa suits all skin types best, while Sesderma suits sensitive, hyperpigmented, and aging skin types best. Both brands provide thoughtful solutions for particular concerns, such as the Japanese brand's Perfect UV Sunscreen Skincare Milk and Gel alongside the Spanish brand's Azelac RU Serum. Ultimately, the brands differ in their core product focus and ideal skin types, guiding individuals toward tailored daily protection and targeted care.

Anessa is a Japanese skincare brand founded in 1992 and owned by Shiseido Company, Limited.

[anessaco.com](https://anessaco.com/about/) [en.wikipedia.org](https://en.wikipedia.org/wiki/Shiseido) [corp.shiseido.com](https://corp.shiseido.com/en/company/talk/20240625.html) [happi.com](https://www.happi.com/top-company-profile/shiseido/)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Anessa and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg582ca8c2b4).

### Popular Anessa vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [$60.00 at Amazon](https://www.amazon.com/dp/B00987RKWW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

#### Anessa

- [Perfect UV Sunscreen Skincare Milk](https://lovi.care/skincare/p/anessa/perfect-uv-sunscreen-skincare-milk/for/oily-skin) — High fit — [$31.85 at Amazon](https://www.amazon.com/dp/B09P8D66Z1?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Perfect UV Sunscreen Skincare Gel](https://lovi.care/skincare/p/anessa/perfect-uv-sunscreen-skincare-gel/for/sensitive-skin) — High fit — [$28.00 at Amazon](https://www.amazon.com/dp/B09P8G5KH7?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Anessa or Sesderma: which is better?

Both brands offer strong options depending on your needs, with Anessa providing sunscreen products that Lovi rates as High fit for oily, acne-prone, and mature skin. Sesderma features the Azelac RU [Serum](https://lovi.care/skincare/ingredients/serum), which Lovi rates as High fit for acne-prone skin and skin with dark spots.

### What is the difference between Anessa and Sesderma?

Anessa offers fragrance-free sunscreens with High Lovi fit for oily, acne-prone, and mature skin types, whereas Sesderma provides a serum that contains fragrance and achieves a High Lovi fit specifically for acne-prone skin and skin with dark spots.

### Which is more affordable, Anessa or Sesderma?

This public Lovi page does not provide pricing or affordability information for either Anessa or Sesderma products.

### Which causes fewer breakouts, Anessa or Sesderma?

Anessa is a better fit for acne-prone skin, as its products on this page achieve a High Lovi fit for acne-prone and oily acne-prone skin, whereas Sesderma achieves an Average fit. Additionally, every Anessa product on this page lists no fragrance, which helps reduce the risk of irritation.

### Where were Anessa and Sesderma founded and when?

Anessa was founded in Japan in 1992, while Sesderma was founded in Spain in 1989.

### Which brand has products with no fragrance listed in their ingredients?

Anessa has fragrance-free options because every product on this page lists no fragrance in its ingredients, whereas Sesderma includes fragrance in its serum.

### How does the Lovi fit level for dry skin compare between Anessa's Perfect UV Sunscreen Skincare Milk and Sesderma's Azelac RU Serum?

Anessa has an Average Lovi fit level for dry skin with its Perfect UV Sunscreen Skincare Milk, while Sesderma has a Low fit level with its Azelac RU Serum.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter](https://pubmed.ncbi.nlm.nih.gov/18503414/) Titanium dioxide · International Journal of Cosmetic Science, 2000
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf extract · Clinical Pharmacology, 2018
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair](https://pubmed.ncbi.nlm.nih.gov/35245682/) Dipotassium glycyrrhizate · Acta Biomaterialia, 2022
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide](https://pubmed.ncbi.nlm.nih.gov/11509913/) Titanium dioxide · Skin Pharmacology and Applied Skin Physiology, 2001
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [In vivo and in vitro evaluation of octyl methoxycinnamate liposomes](https://pubmed.ncbi.nlm.nih.gov/24376350/) Ethylhexyl methoxycinnamate · International Journal of Nanomedicine, 2013
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl methoxycinnamate · Archives of Dermatological Research, 2024
- [Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin](https://pubmed.ncbi.nlm.nih.gov/39138602/) Ethylhexyl methoxycinnamate · International Journal of Cosmetic Science, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026

## The brands

- Japanese skincare: [Anessa](https://lovi.care/skincare/brands/anessa)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/brands/sesderma)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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