# ZO Skin Health Growth Factor Serum for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [ZO Skin Health](https://lovi.care/skincare/ca/brands/zo-skin-health)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this serum utilizes dipeptide diaminobutyroyl benzylamide diacetate and buddleja davidii meristem cell culture to effectively minimize fine lines and wrinkles while also soothing redness and irritation.
- The inclusion of hydrolyzed sericin and ethyl linoleate further supports skin hydration and barrier function, complementing the primary anti-aging and calming benefits.
- The product is safe for your sensitive skin, containing no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Dipeptide Diaminobutyroyl Benzylamide Diacetate, Adenosine Triphosphate, Beta-Glucan, Angelica Polymorpha Sinensis Root Extract, Hydrolyzed Sericin

## What the research says

- A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/))
- Verbascoside- and teupolioside-containing extracts significantly accelerated wound healing, exhibited anti-inflammatory action, inhibited reactive oxygen species release, and suppressed chemokine and growth factor expression in cultured human keratinocytes compared to pro-inflammatory controls. ([Cellular and Molecular Biology, 2007](https://pubmed.ncbi.nlm.nih.gov/17543237/))
- Knockout of the TRPV3 gene and topical applications of selective TRPV3 inhibitors osthole and verbascoside alleviate UVB-induced skin inflammation and lesions in mice. ([FASEB Journal, 2023](https://pubmed.ncbi.nlm.nih.gov/37983944/))
- The application of a vitamin B12 and adenosine triphosphate complex improved skin radiance, elasticity, and texture in human participants. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/39194754/))
- Direct delivery of intracellular adenosine triphosphate using ATP-encapsulated fusogenic small unilamellar lipid vesicles accelerated wound healing, improved granular tissue development, re-epithelialization, and increased vascular endothelial growth factor expression compared to lipid vesicles alone in adult nude mice. ([American Journal of Surgery, 2007](https://pubmed.ncbi.nlm.nih.gov/17236849/))
- A self-powered chloroplast-driven nanophotosystem consisting of Chlorella-derived nanothylakoid units and hyaluronic acid microneedles increased mitochondrial biogenesis, adenosine triphosphate generation, and NAD(P)H pools in senescent fibroblasts, leading to increased collagen synthesis and alleviated skin photoaging. ([Journal of Nanobiotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42144642/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Angelica sinensis essential oil at 5%-10% demonstrated significant anti-acne effects comparable to adapalene gel with reduced side effects in mice by suppressing Cutibacterium acnes and downregulating IL-1β. ([Journal of Ethnopharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41482092/))
- An Angelica sinensis extract containing 1% ligustilide demonstrated anti-inflammatory, antioxidant, anti-senescence, matrix-supportive, and antimicrobial effects in human keratinocytes and dermal fibroblasts. ([Frontiers in Pharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41948733/))
- Topical application of Angelica sinensis extract induced noticeable hair regrowth, restored hair shaft lengths and follicle size, and decreased apoptotic cells in C57BL/6 mice. ([The American Journal of Chinese Medicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25004889/))
- Bacterial cellulose wound dressing containing silk sericin and PHMB improved wound quality and reduced pain compared to Bactigras in patients with split-thickness skin graft donor-site wounds. ([Archives of Dermatological Research, 2018](https://pubmed.ncbi.nlm.nih.gov/30302557/))
- A bacterial nanocellulose wound dressing incorporating polyhexamethylene biguanide and sericin showed no skin irritation in healthy volunteers and significantly promoted wound healing with lower wound size and higher collagen formation in full-thickness rat wounds compared to controls. ([Archives of Dermatological Research, 2016](https://pubmed.ncbi.nlm.nih.gov/26796543/))
- Topical application of sericin gels increased skin intrinsic moisturization, hydroxyproline content, and epidermal hydration while decreasing transepidermal water loss and skin impedance in healthy human volunteers. ([Journal of Cosmetic Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/17168872/))

## What reviewers say

Based on a very large amount of data, this product is highly regarded by users with aging, dry, and sensitive skin for its hydrating and plumping effects, visibly reducing fine lines. The lightweight gel formula is frequently praised for restoring the skin's moisture barrier and improving texture. However, some users with acne-prone skin report breakouts, and the high price is a common concern.

- Liked: Lightweight gel (mostly mentioned)
- Liked: Hydrating, plumping (often mentioned)
- Disliked: Very expensive (often mentioned)
- Liked: Gentle, soothing (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Faulty pump (rarely noted)
- Disliked: Pills under makeup (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ZO Growth Factor Serum a great fit for sensitive skin?

This serum is a great fit for sensitive skin because it helps smooth fine lines while calming redness and irritation with ingredients like dipeptide diaminobutyroyl benzylamide diacetate and beta-glucan. It also supports hydration and barrier strength with hydrolyzed sericin, and has a safe formula that is unlikely to cause irritation.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum is a great fit for sensitive skin because it uses dipeptide diaminobutyroyl benzylamide diacetate and buddleja davidii meristem cell culture to help smooth lines while calming redness and irritation. Hydrolyzed sericin and ethyl linoleate further support hydration and barrier strength, and the formula contains no harsh ingredients that might upset your skin.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Dipeptide Diaminobutyroyl Benzylamide Diacetate do for sensitive skin?

Dipeptide diaminobutyroyl benzylamide diacetate helps smooth fine lines and improves overall skin texture while remaining gentle on sensitive skin. Clinical studies show that when it is included in an anti-aging serum alongside ingredients like acetyl hexapeptide-8 and gluconolactone, it significantly boosts skin biomarkers and reduces both static and dynamic wrinkles without causing irritation.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Adenosine Triphosphate do for sensitive skin?

Adenosine Triphosphate is unlikely to irritate sensitive skin and helps keep cells energized against daily environmental stress. This ingredient supports normal skin function and may protect delicate skin from damage when it faces outside stressors.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after your cleansing and toning steps, before you apply your moisturizer. Using treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help calm redness before layering your retinol. This product is safe and unlikely to cause irritation on sensitive skin.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### How often should I use this serum?

You can use this treatment serum in the evening as part of your routine. It is a great fit for sensitive skin because it is very safe and unlikely to cause irritation while helping to calm redness.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to cause breakouts or clog pores for sensitive skin, as it contains no harsh or prohibited ingredients that trigger irritation. Reviewers rarely report breakouts, and the formula helps smooth and calm your skin while supporting hydration.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Oleyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — CA$33.98 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — CA$24.44 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/sensitive-skin) — High fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone Peg-10 15 Crosspolymer, Peg-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Parfum, Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/zo-skin-health/growth-factor-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/sensitive-skin