# Youth To The People Polypeptide-121 Future Cream for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Youth To The People](https://lovi.care/skincare/ca/brands/youth-to-the-people)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing and treatment for your normal skin, as hydrolyzed hyaluronic acid and niacinamide hydrate and enhance barrier resilience, while bisabolol and aloe barbadensis leaf juice soothe redness and irritation.
- The inclusion of ceramides and phytosphingosine further supports barrier repair, making it a well-rounded choice for maintaining skin health.
- The product is safe for your sensitive skin, containing no harsh ingredients and featuring soothing components like bisabolol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Biotech Collagen, Hydrolyzed Hyaluronic Acid, Niacinamide, Acetyl Tetrapeptides, Aloe Barbadensis Leaf Juice

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical application of an emulsion containing a complete mixture of ceramides III, IIIB, VI, phytosphingosine, cholesterol, and linoleic acid significantly accelerated barrier recovery after SLS damage and improved skin hydration after acetone treatment in human volunteers compared to an emulsion containing only two types of ceramides. ([Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## What reviewers say

Based on a very large amount of data, users with dry and sensitive skin frequently praise this cream for its ability to provide deep, long-lasting hydration without feeling heavy, often describing a "dewy" and "plump" finish. Many appreciate its barrier-strengthening ingredients and lightweight texture under makeup. Some users with oily or acne-prone skin experienced breakouts, and others found the price point too high for the amount of product provided.

- Liked: Deep hydration (mostly mentioned)
- Liked: Lightweight texture (mostly mentioned)
- Liked: Makeup compatibility (often mentioned)
- Disliked: Expensive for size (often mentioned)
- Liked: Soothing formula (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Unhygienic packaging (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Youth To The People Polypeptide-121 Future Cream a great fit for sensitive skin?

This moisturizer is a great fit because it contains soothing ingredients like bisabolol and aloe barbadensis leaf juice that help calm redness and irritation. It also features hydrolyzed hyaluronic acid and niacinamide to hydrate the skin while ceramides support barrier repair without any harsh components.

### Which ingredients make this cream a good fit for sensitive skin?

This cream is a great fit for sensitive skin because it features soothing components like bisabolol and aloe barbadensis leaf juice that help calm redness and irritation. It is also safe and gentle, containing no harsh ingredients while supporting the skin barrier.

### What does Biotech Collagen do for sensitive skin?

Biotech Collagen helps calm and protect sensitive skin by strengthening the skin barrier and reducing irritation. It has a great safety profile and may help soothe redness and support recovery in delicate skin.
Sources: [Frontiers in Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/41767529/), [Biomaterials Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41626806/)

### What does Hydrolyzed Hyaluronic Acid do for sensitive skin?

Hydrolyzed hyaluronic acid helps hydrate and calm sensitive skin while improving skin texture. It is unlikely to cause irritation due to its very good safety profile.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/)

### Where does this cream go in a skincare routine for sensitive skin?

This moisturizing treatment goes in the evening routine after your cleansing and soothing toner steps. It helps hydrate and soothe sensitive skin while supporting barrier repair.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, and applying it after your retinol helps calm redness and dryness while supporting your skin barrier. Barrier-enhancing moisturizers reduce irritation and make it easier for sensitive skin to adjust to retinoids.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment daily in your evening routine, applying it after cleansing and toning. Using a hydrating moisturizer twice daily helps maintain skin moisture and supports the skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for sensitive skin because it is safe and features gentle, soothing ingredients without harsh additives. Reviewers rarely report breakouts from this product.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because it features a safe profile with soothing ingredients like bisabolol and aloe leaf juice. Clinical studies show that applying creams with hyaluronic acid and botanical extracts to the eye area is well-tolerated and helps reduce fine lines.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — CA$30.98 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-96-mucin-power-essence/for/sensitive-skin) — Superior fit — CA$24.99 at Amazon
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — CA$26.18 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Dicaprylyl Carbonate, Hydrolyzed Hyaluronic Acid, Trimethylolpropane Tricaprylate Tricaprate, Tridecyl Trimellitate, Propanediol, Sh-Polypeptide-121, Polyglyceryl-3 Methylglucose Distearate, Panthenol, Niacinamide, Proline, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Hydrolyzed Cannabis Sativa Seed Extract Cannabis Sativa Seed Extract, Hydrolyzed Rice Protein, Hydrolyzed Pea Protein, Salvia Hispanica Seed Extract, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Hibiscus Sabdariffa Fruit Extract, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Hydrolyzed Linseed Seed, Castor Ipdi Copolymer Oil, Ceramide Ap, Ceramide Np, Cetearyl Alcohol, Cetearyl Glucoside, Glycerin, Hydrolyzed Sodium Hyaluronate, Coco-Caprylate Caprate, Dilinoleic Acid Propanediol Pdi Crosspolymer, Benzyl Alcohol, Zingiber Officinale Root Extract, Bisabolol, Caprylyl Glycol, Carbomer, Dimethyl Isosorbide, Dipropylene Glycol, Erythritol, Ethylhexylglycerin, Glucose, 1,2-Hexanediol, Trisodium Ethylenediamine Disuccinate, Glyceryl Monostearate, Phytosphingosine, Polyacrylate Crosspolymer-6, Polysorbate 20, Caprylhydroxamic Acid, Potassium Sorbate, Glycine, Hydroxyacetophenone, Sodium Benzoate, T-Buty Alcohol, Citric Acid, Sodium Citrate, Sodium Lactate, Triheptanoin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin