# Vichy Liftactiv Pure Retinol Serum for sensitive skin

**Lovi Fit: Low fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Concerning.

Page: https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Vichy](https://lovi.care/skincare/ca/brands/vichy)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for sensitive skin; the serums alongside fit it better.

## Why this fit

- Offers moderate treatment for minimizing fine lines and wrinkles for your normal skin due to the presence of retinol and palmitoyl tripeptide-1, which stimulate collagen and promote anti-aging effects.
- While sodium hyaluronate provides humectant action, the retinol concentration poses a major risk of worsening redness and irritation for your sensitive skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin): Low (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Sodium Hyaluronate, Palmitoyl Tetrapeptide-7, Hydrolyzed Rice Protein, Glycerin

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## Why other serums fit sensitive skin better

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is Vichy Liftactiv Retinol Serum a weak match for sensitive skin?

This product is a weak match for sensitive skin because the retinol concentration poses a major risk of worsening redness and irritation. Sensitive skin needs products with effective soothing ingredients that calm redness and irritation, while posing no risk of irritation.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this serum a poor fit for sensitive skin?

This serum is a weak match for sensitive skin because the retinol concentration poses a major risk of worsening redness and irritation. To fit this skin type well, a treatment of this type needs soothing and calming ingredients like niacinamide and snail secretion filtrate to support skin health without causing discomfort.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Retinol do for sensitive skin?

Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after your soothing toner and before your moisturizer. A product of this type needs calming ingredients like soothing extracts and hydrating helpers to keep sensitive skin comfortable and prevent redness.

### Can I use this serum with vitamin C, and in what order?

It is best to avoid using this serum in the same routine with vitamin C, as layering these active ingredients may increase the likelihood of redness and irritation on sensitive skin. Instead, apply vitamin C in your morning routine and save this treatment for the evening. Sensitive skin needs gentle ingredients like soothing botanical extracts, glycerin, and hyaluronic acid to keep the skin calm and hydrated.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum is a weak match for sensitive skin because the retinol concentration poses a major risk of worsening redness and irritation. To use this product safely on sensitive skin, a treatment of this type needs soothing ingredients like calming plant extracts and hydrating agents to keep the skin calm and comfortable.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum may cause redness, irritation, and flaking on sensitive skin due to its strong retinol content. To work well for this skin type, a product of this type needs soothing ingredients like glycerin and sodium hyaluronate to keep the skin calm and comfortable.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — CA$33.98 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — CA$24.44 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/sensitive-skin) — High fit — CA$14.40 at Amazon

## Routine for sensitive skin

### AM

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/ca/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — CA$17.99 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Serum or Treatment: [Purito Centella Unscented Serum](https://lovi.care/skincare/ca/p/purito/centella-unscented-serum/for/sensitive-skin) — Superior fit — CA$23.25 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — CA$30.98 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/ca/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — CA$17.99 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Enzyme Powder: [Dr. Barbara Sturm Enzyme Cleanser](https://lovi.care/skincare/ca/p/dr-barbara-sturm/enzyme-cleanser/for/sensitive-skin) — High fit — CA$157.17 at Amazon
- Nourishing Mask: [Anua Heartleaf 77% Soothing Sheet Mask](https://lovi.care/skincare/ca/p/anua/heartleaf-77-soothing-sheet-mask/for/sensitive-skin) — Superior fit — CA$10.00 at Amazon
- Serum or Treatment: [Purito Centella Unscented Serum](https://lovi.care/skincare/ca/p/purito/centella-unscented-serum/for/sensitive-skin) — Superior fit — CA$23.25 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — CA$30.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Pentylene Glycol, Isononyl Isononanoate, Alcohol Denat, Dicaprylyl Ether, Glycine Soja Oil, Soybean Oil, Propylene Glycol, Peg-6 Caprylic Capric Glycerides, Hydrolyzed Rice Protein, Hydroxyacetophenone, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Vitreoscilla Ferment, Retinol, Dicaprylyl Carbonate, Ammonium Polyacryloyldimethyl Taurate, Butylene Glycol, Caprylyl Glycol, Carbomer, Glyceryl Isostearate, Polysorbate 20, Ppg-6-Decyltetradeceth-30, Sodium Lactate, Tocopherol, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin