# The INKEY List Niacinamide Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [The INKEY List](https://lovi.care/skincare/ca/brands/the-inkey-list)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Suitable for normal skin, this serum utilizes niacinamide for mild seboregulation and glycerin for humectant action, offering general hydration that can support the appearance of fine lines and wrinkles.
- Panthenol and allantoin provide soothing benefits, contributing to overall skin comfort and texture improvement.
- The product is safe for your normal skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of calming components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glycerin, Squalane, Sodium Hyaluronate, Leuconostoc Radish Root Ferment Filtrate

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, users with oily and blemish-prone skin frequently praise this serum for its ability to regulate sebum production and calm active breakouts without stripping moisture. The majority report clearer skin and reduced redness. A notable minority experience texture issues, such as a sticky finish or white residue if the product is not applied carefully.

- Liked: Controls excess oil (often mentioned)
- Liked: Great value & packaging (often mentioned)
- Liked: Reduces redness & blemishes (often mentioned)
- Liked: Hydrating & lightweight (sometimes noted)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Sticky or tacky finish (sometimes noted)
- Disliked: White residue/crystallization (sometimes noted)
- Disliked: Caused breakouts/irritation (rarely noted)
- Disliked: Foaming/soaping effect (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The INKEY List Niacinamide work for mature skin?

This serum works for mature skin, though other products fit it better because it provides general hydration that can support the appearance of fine lines and wrinkles. To better suit mature skin, a product of this type needs potent antioxidants, hydrating components, skin-repairing ingredients, and peptides for optimal moisture retention and skin elasticity.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

This serum fits mature skin through niacinamide, glycerin, squalane, and sodium hyaluronate, which help keep the skin hydrated and support the appearance of fine lines. To fit mature skin even better, a product of this type needs high-concentrate antioxidants, peptides, and skin-repairing ingredients that target signs of aging.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine, applied after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and avoids extra safety concerns with sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum before your retinol product at night. This product helps keep your skin comfortable and hydrated, but mature skin generally benefits more from targeted anti-aging treatments containing peptides, antioxidants, and rich nourishing oils.

### How often should I use this serum?

Use this treatment serum in the evening. Mature skin needs products with powerful antioxidants, retinoids, or peptides to deeply firm and smooth lines.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or irritation, as reviews show very few complaints about clogged pores and the formula includes calming ingredients. Mature skin generally benefits most from products that combine rich moisturizers like squalane with targeted firming peptides or antioxidants for deeper wrinkle care.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/mature-skin) — High fit — CA$27.99 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/mature-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

- Amazon.ca: CA$30.33 (https://www.amazon.ca/dp/B09PP2DK5W?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Sephora: CA$18.00 (https://www.sephora.com/ca/en/product/the-inkey-list-niacinamide-oil-control-serum-P464815?skuId=2404465)
Prices checked 10 Oct – 2 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Propanediol, Butylene Glycol, Phenoxyethanol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethylcellulose, Squalane, Xanthan Gum, Glycine Soja Oil Soybean Oil, Allantoin, Sodium Phytate, Polysorbate 60, Panthenol, Glycolipids, Leuconostoc Radish Root Ferment Filtrate, Sorbitan Isostearate, Glycine Soja Soybean Sterols, Citric Acid, Sodium Hyaluronate, Disodium Phosphate, Sodium Phosphate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/the-inkey-list/niacinamide-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/the-inkey-list/niacinamide-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-inkey-list/niacinamide-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-inkey-list/niacinamide-serum/for/mature-skin